Genomic particularities of the thrombophilic status in Type 2 diabetic patients

Abstract

Type 2 diabetes mellitus (T2DM) is a very common disease, which is characterized by a prothrombotic status, very frequently leading to severe complications.The thrombophillic status results from chronic activation of the coagulation system, associated with a decrease in the endogenous fibrinolytic capacity. The objective of this study was to evaluate the thrombotic status in type 2 diabetic patients and to establish if the genomic polymorphisms of the haemostatic factors favor the increase of thrombosis in insulin resistance statuses. The research was done on a group of 60 patients with T2DM. Metabolic parameters such asserum glucose, total cholesterol, LDL, HDL, triglycerides, glycated hemoglobin and renal function indicators were assessed after 12 hours of fasting. The haemostasis was investigated through the levels of fibrinogen, thrombocytes count and morphology, the antithrombin III plasmatic concentration, the presence of different PAI-1 and coagulation factor XIII genotypes. The study revealed that PAI-14G/4G genotype was associated with high glycated hemoglobin levels and with increased total and LDL cholesterol, while the other PAI-1 genotypes had no such associations. Our research also showed that the mutant WT+MT factor XIII heterozygote was associated with high total and LDL cholesterol levels and with increased CRP concentrations.