Genomic organization and expression of mouse Tpt1 gene☆

Fiucci, Giusy; Lespagnol, Alexandra; Stumptner-Cuvelette, Pamela; Beaucourt, Séverine; Duflaut, Dominique; Susini, Laurent; Amson, Robert; Telerman, Adam

doi:10.1016/s0888-7543(03)00047-8

Cited by 23 publications

(17 citation statements)

References 30 publications

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“…A very similar structure was also reported for the mouse (Fiucci et al 2003) and the human (Andree et al 2006) TPT1 gene. The latter has been mapped to chromosome 13, q12-->q14 , the mouse gene to chromosome 14 (Fiucci et al 2003) and the pig TPT1 gene to chromosome 11 (Yubero et al 2009), in a genomic context that is similar to that of the human chromosomal location.…”

Section: Gene Structure and Mrnasupporting

confidence: 77%

“…The promoter regions of the active TPT1 gene were further investigated for the rabbit (Thiele et al 1998), mouse (Fiucci et al 2003) and human (Andree et al 2006) genes. They displayed a large number of transcription factor-binding motifs, i.e.…”

Section: Gene Structure and Mrnamentioning

confidence: 99%

“…Several of these pseudogenes have been studied in some detail in the rabbit (Thiele et al 2000) and in mouse (Fiucci et al 2003), and only few were found to have the potential to produce a protein product.…”

Section: Gene Structure and Mrnamentioning

confidence: 99%

“…The ratio between the two mRNA species differs considerably between different tissues, but the short mRNA is always in excess (Thiele et al 2000). The importance for the production of these two different mRNA species has not yet been elucidated, but interestingly, in mouse tissues, there was only one TCTP mRNA isoform detected (Fiucci et al 2003).…”

Section: Gene Structure and Mrnamentioning

confidence: 99%

“…. for the human, mouse and rabbit mRNAs (Thiele et al 1998(Thiele et al , 2000Fiucci et al 2003). The 5 0 -TOP motif is a hallmark for a specific group of mRNAs that are under translational control through the mTOR complex 1 (mTORC1) signalling pathway (Meyuhas and Kahan 2015;Yamashita et al 2008).…”

Section: Gene Structure and Mrnamentioning

confidence: 99%

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The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

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The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes. It was first discovered about 35 years ago, and it took an extended period of time for its multiple functions to be revealed, and even today we do not yet fully understand all the details. Having witnessed most of this history, in this chapter, I give a brief overview and review the current knowledge on the structure, biological functions, disease involvements and cellular regulation of this protein. TCTP is able to interact with a large number of other proteins and is therefore involved in many core cell biological processes, predominantly in the response to cellular stresses, such as oxidative stress, heat shock, genotoxic stress, imbalance of ion metabolism as well as other conditions. Mechanistically, TCTP acts as an anti-apoptotic protein, and it is involved in DNA-damage repair and in cellular autophagy. Thus, broadly speaking, TCTP can be considered a cytoprotective protein. In addition, TCTP facilitates cell division through stabilising the mitotic spindle and cell growth through modulating growth signalling pathways and through its interaction with the proteosynthetic machinery of the cell. Due to its activities, both as an anti-apoptotic protein and in promoting cell growth and division, TCTP is also essential in the early development of both animals and plants. Apart from its involvement in various biological processes at the cellular level, TCTP can also act as an extracellular protein and as such has been involved in modulating whole-body defence processes, namely in the mammalian immune system. Extracellular TCTP, typically in its dimerised form, is able to induce the release of cytokines and other signalling molecules from various types of immune cells. There are also several examples, where TCTP was shown to be involved in antiviral/antibacterial defence in lower animals. In plants, the protein appears to have a protective effect against phytotoxic stresses, such as flooding, draught, too high or low temperature, salt stress or exposure to heavy metals. The finding for the latter stress condition is corroborated by earlier reports that TCTP levels are considerably up-regulated upon exposure of earthworms to high levels of heavy metals. Given the involvement of TCTP in many biological processes aimed at maintaining cellular or whole-body homeostasis, it is not surprising that dysregulation of TCTP levels may promote a range of disease processes, foremost cancer. Indeed a large body of evidence now supports a role of TCTP in at least the most predominant types of human cancers. Typically, this can be ascribed to both the anti-apoptotic activity of the protein and to its function in promoting cell growth and division. However, TCTP also appears to be involved in the later stages of cancer progression, such ...

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Section: Gene Structure and Mrnasupporting

confidence: 77%

Section: Gene Structure and Mrnamentioning

confidence: 99%

Section: Gene Structure and Mrnamentioning

confidence: 99%

Section: Gene Structure and Mrnamentioning

confidence: 99%

Section: Gene Structure and Mrnamentioning

confidence: 99%

See 3 more Smart Citations

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

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Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: Expression, distribution, and calcium binding activity

et al. 2004

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Serological identification and bioinformatics analysis of immunogenic antigens in multiple myeloma

Zhou

Zhang

Chen

et al. 2005

Cancer Immunol Immunother

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Identifying appropriate tumor antigens is critical to the development of successful specific cancer immunotherapy. Serological analysis of tumor antigens by a recombinant cDNA expression library (SEREX) allows the systematic cloning of tumor antigens recognized by the spontaneous autoantibody repertoire of cancer patients. We applied SEREX to the cDNA expression library of cell line HMy2, which led to the isolation of six known characterized genes and 12 novel genes. Known genes, including ring finger protein 167, KLF10, TPT1, p02 protein, cDNA FLJ46859 fis, and DNMT1, were related to the development of different tumors. Bioinformatics was performed to predict 12 novel MMSA (multiple myeloma special antigen) genes. The prediction of tumor antigens provides potential targets for the immunotherapy of patients with multiple myeloma (MM) and help in the understanding of carcinogenesis. Crude lysate ELISA methodology indicated that the optical density value of MMSA-3 and MMSA-7 were significantly higher in MM patients than in healthy donors. Furthermore, SYBR Green real-time PCR showed that MMSA-1 presented with a high number of copy messages in MM. In summary, the antigens identified in this study may be potential candidates for diagnosis and targets for immunotherapy in MM.

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Genomic organization and expression of mouse Tpt1 gene☆

Cited by 23 publications

References 30 publications

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: Expression, distribution, and calcium binding activity

Serological identification and bioinformatics analysis of immunogenic antigens in multiple myeloma

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