Genomic imprinting in mammalian development: a parental tug-of-war

Moore, Tom; Haig, David

doi:10.1016/0168-9525(91)90230-n

Cited by 911 publications

(627 citation statements)

References 26 publications

Supporting

Mentioning

569

Contrasting

Unclassified

Order By: Relevance

“…5 Early studies delineating the function of imprinted genes indicated a trend in which paternally expressed genes are involved in processes that increase nutritional intake to maximize fetal growth and maternally expressed genes are involved in processes that restrict fetal growth to preserve maternal fitness. 6 While this hypothesis has not been entirely validated, these studies do suggest that appropriate fetal growth is dictated by the carefully-regulated balance in the expression of these genes.…”

Section: Introductionmentioning

confidence: 99%

Placental expression profile of imprinted genes impacts birth weight

et al. 2015

View full text Add to dashboard Cite

The importance of imprinted genes in regulating feto-placental development has been long established. However, a comprehensive assessment of the role of placental imprinted gene expression on fetal growth has yet to be conducted. In this study, we examined the association between the placental expression of 108 established and putative imprinted genes and birth weight in 677 term pregnancies, oversampled for small for gestational age (SGA) and large for gestational age (LGA) infants. Using adjusted multinomial regression analyses, a 2-fold increase in the expression of 9 imprinted genes was positively associated with

show abstract

Section: Introductionmentioning

confidence: 99%

Placental expression profile of imprinted genes impacts birth weight

et al. 2015

View full text Add to dashboard Cite

show abstract

“…This pattern cannot be explained as a result of sex limitation or sex linkage but could readily result from genomic imprinting, with silencing of maternally inherited alleles in all offspring (Spencer 2002). Such parent-of-origin effects are known in a wide range of taxa, including Drosophila (Lloyd 2000), mammals (Monk 1987;Moore and Haig 1991;de Koning et al 2000;Rattink et al 2000;Goos and Silverman 2001;Moore 2001), birds (Tuiskula-Haavisto et al 2004), and plants (Alleman and Doctor 2000), and typically appear to play a role in the regulation of organ development and growth. Reduced autosomal recombination rate in males (Lenormand 2003) could contribute to this result.…”

Section: Proximate Mechanismsmentioning

confidence: 99%

Intralocus Sexual Conflict and the Genetic Architecture of Sexually Dimorphic Traits in Prochyliza Xanthostoma (Diptera: Piophilidae)

2005

View full text Add to dashboard Cite

Abstract. Because homologous traits of males and females are likely to have a common genetic basis, sex-specific selection (often resulting from sexual selection on one sex) may generate an evolutionary tug-of-war known as intralocus sexual conflict, which will constrain the adaptive divergence of the sexes. Theory suggests that intralocus sexual conflict can be mitigated through reduction of the intersexual genetic correlation (r MF ), predicting negative covariation between r MF and sexual dimorphism. In addition, recent work showed that selection should favor reduced expression of alleles inherited from the opposite-sex parent (intersexual inheritance) in traits subject to intralocus sexual conflict. For traits under sexual selection in males, this should be manifested either in reduced maternal heritability or, when conflict is severe, in reduced heritability through the opposite-sex parent in offspring of both sexes. However, because we do not know how far these hypothesized evolutionary responses can actually proceed, the importance of intralocus sexual conflict as a long-term constraint on adaptive evolution remains unclear. In this study, we investigated the genetic architecture of sexual and nonsexual morphological traits in Prochyliza xanthostoma. The lowest r MF and greatest dimorphism were exhibited by two sexual traits (head length and antenna length) and, among all traits, the degree of sexual dimorphism was correlated negatively with r MF . Moreover, sexual traits exhibited reduced maternal heritabilities, and the most strongly dimorphic sexual trait (antenna length) was heritable only through the same-sex parent in offspring of both sexes. Our results support theory and suggest that intralocus sexual conflict can be resolved substantially by genomic adaptation. Further work is required to identify the proximate mechanisms underlying these patterns.

show abstract

“…The most widely cited of these is the conflict or kinship 299" theory for the evolution of imprinting (Haig and Graham, 1991;Moore and Haig, 1991). This 300" predicts that the conceptus (placenta and offspring), which inherits approximately half of its 301" genes from its mother and half from its father, may be a site for potential conflict between the 302" two parental genomes.…”

Section: "mentioning

confidence: 99%

Genomic imprinting and mammalian reproduction

Swaney

2011

Hormones and Behavior

View full text Add to dashboard Cite

Genomic imprinting in mammalian development: a parental tug-of-war

Cited by 911 publications

References 26 publications

Placental expression profile of imprinted genes impacts birth weight

Placental expression profile of imprinted genes impacts birth weight

Intralocus Sexual Conflict and the Genetic Architecture of Sexually Dimorphic Traits in Prochyliza Xanthostoma (Diptera: Piophilidae)

Genomic imprinting and mammalian reproduction

Contact Info

Product

Resources

About