Genomic Epidemiology of Streptococcus suis Sequence Type 7 Sporadic Infections in the Guangxi Zhuang Autonomous Region of China

Wang, Mingliu; Du, Pengcheng; Wang, Jianping; Lan, Ruiting; Huang, Jun; Luo, Ming; Jiang, Yan; Zeng, Jun; Quan, Yi; Z, Shi; Zheng, Han

doi:10.3390/pathogens8040187

Cited by 18 publications

(29 citation statements)

References 39 publications

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“…Serotype 2, ST7 isolates were another predominant sequence type and responsible for the 1998 and 2005 Chinese epidemics, which caused a total of 240 human infections, 52 of whom dead [2]. Surveillance for S.suis has been ongoing since last outbreak in our country [3][4][5]. Here we report two cases of successfully cured human infection with ST7 SS2.…”

Section: Introductionmentioning

confidence: 86%

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Human infection caused by Streptococcus suis serotype 2 in China: report of two cases and epidemic distribution based on sequence type

et al. 2020

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Background: Streptococcus suis is a zoonotic pathogen that causes serious systemic infections in pigs and occupation-related infections in humans who contact with pigs or pork products. In China, it has caused two outbreaks of human infection and surveillance for S.suis has been ongoing since last time. Case presentation: Two cases of meningitis and sepsis caused by S. suis were reported in this study. Both patients work in relation to the pork trade, a risk factor for S. suis infection. The outcome was favorable after a prolonged ceftriaxone therapy but one patient was left with mild hearing loss. Two isolates were identified as sequencing type (ST) 7, S. suis serotype 2 (SS2), which is one the most prevalent and cause two outbreaks in China. Whole-genome sequencing (WGS) revealed that a high degree identity was noted in the genome organizations and sequences between two sporadic ST7 SS2 isolates in this study and representative epidemic virulent isolates. Major differences among them are two sporadic ST7 SS2 isolates lacked a virulence factor called agglutinin receptor and an 89 K pathogenicity island (PAI), which plays important role in the pathogenesis of streptococcal toxic shock syndrome (STSS). A summary about STs of human infection with S. suis in China was completed. The result showed ST1 and ST7 were still the major STs and several novel STs were successfully discovered in different provinces. Conclusions: Our results enhanced the understanding of the ability to cause life-threatening infections in humans and the distribution and evolution of the S. suis in China.

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Section: Introductionmentioning

confidence: 86%

“…According to the MLST database (https://pubmlst.org/ ssuis) and previous geographic reviews [1,[3][4][5][6], we summarized and mapped the geographic distribution of S.suis causing human infection in China. The collected epidemiological data showed that S. suis cases occur mainly in South China.…”

Section: Cases Presentationmentioning

confidence: 99%

Human infection caused by Streptococcus suis serotype 2 in China: report of two cases and epidemic distribution based on sequence type

et al. 2020

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“…Compared to the genome of the epidemic strain, the major differences in the genome of sporadic ST7 strains were the absence of the 89 kb SsPI-1 (specific to the epidemic strain) and the insertion of MGEs or ICE elements, suggesting a role in horizontal transfer of antibiotic resistance genes [18]. The emergence of these ST7 strains, and importantly within serotype 14 (reported by Wang et al for the first time [47]), highlights the need to have a better understanding of the evolution of zoonotic ST7 strains and their ability to cause life-threatening infections in humans.…”

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confidence: 93%

“…The authors concluded that SsPI-1 is a critical contributor to the evolution of virulence in epidemic S. suis [ 46 ]. Recently, Wang et al [ 47 ] reported 38 sporadic ST7 S. suis strains, which mostly caused sepsis, from patients in the Guangxi Zhuang Autonomous Region between 2007 and 2018. Interestingly, among these sporadic ST7 strains, serotype 14 was the most frequent, followed by serotype 2.…”

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confidence: 99%

Streptococcus suis Research: Progress and Challenges

Segura

2020

Pathogens

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Streptococcus suis is considered among the top bacterial pathogens leading to important economic losses to the swine industry, with the incidence of disease increasing as the prophylactic use of antimicrobial is being vanished worldwide. S. suis is also a zoonotic agent afflicting people in close contact with infected pigs or pork meat. Besides, in some Asian countries, it is considered a major public health concern for the general population as well. Antimicrobial resistance is one of the most important global health challenges, and in the absence of preventive measures (such as effective vaccines), S. suis remains a risk for increased antimicrobial resistance and transmission of resistance genes to other bacteria beyond the host animal species. The studies in this Special Issue have evidenced the importance of swine population demographics and management on disease control, progress in molecular tools to better understand the epidemiology of S. suis infections in swine and humans, and the mechanisms involved in different aspects of the immuno-pathogenesis of the disease. The importance of reducing the prophylactic use of antimicrobials in livestock productions and the development of alternative control measures, including vaccination, are herein discussed.

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“…Meningitis and septicemia develop most frequently as a result of S. suis infection. Fewer cases were often life-threatening endocarditis, septic shock and arthritis [154,161,163]. The mortality rate presented regardless of the clinical presentation is 12-19 % [154,172].…”

Section: Streptococcus Suismentioning

confidence: 99%

Pathogenicity and drug resistance of animal streptococci responsible for human infections

Glajzner

Szewczyk

Szemraj

2021

Journal of Medical Microbiology

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Bacteria of the genus Streptococcus , earlier considered typically animal, currently have also been causing infections in humans. It is necessary to make clinicians aware of the emergence of new species that may cause the development of human diseases. There is an increasing frequency of isolation of streptococci such as S. suis , S. dysgalactiae , S. iniae and S. equi from people. Isolation of Streptococcus bovis/Streptococcus equinus complex bacteria has also been reported. The streptococcal species described in this review are gaining new properties and virulence factors by which they can thrive in new environments. It shows the potential of these bacteria to changes in the genome and the settlement of new hosts. Information is presented on clinical cases that concern streptococcus species belonging to the groups Bovis, Pyogenic and Suis. We also present the antibiotic resistance profiles of these bacteria. The emerging resistance to β-lactams has been reported. In this review, the classification, clinical characteristics and antibiotic resistance of groups and species of streptococci considered as animal pathogens are summarized.

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Genomic Epidemiology of Streptococcus suis Sequence Type 7 Sporadic Infections in the Guangxi Zhuang Autonomous Region of China

Cited by 18 publications

References 39 publications

Human infection caused by Streptococcus suis serotype 2 in China: report of two cases and epidemic distribution based on sequence type

Human infection caused by Streptococcus suis serotype 2 in China: report of two cases and epidemic distribution based on sequence type

Streptococcus suis Research: Progress and Challenges

Pathogenicity and drug resistance of animal streptococci responsible for human infections

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