Genomic Correlates of DNA Damage in Breast Cancer Subtypes

Morafraile, Esther Cabañas; Pérez-Peña, Javier; Fuentes-Antrás, Jesús; Manzano, Aránzazu; Pérez‐Segura, Pedro; Pandiella, Atanasio; Galán-Moya, Eva María; Ocaña, Alberto

doi:10.3390/cancers13092117

Cited by 3 publications

(2 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, it has been shown to contribute to the ubiquitination and degradation of breast cancer gene 1 (BRCA1) (28,47,(52)(53)(54). It interacts with the BRCA1/BRCA1 associated RING domain 1 (BARD1) complex in breast cancer (BrC) cells and causes the degradation of BRCA1.…”

Section: Ube2tmentioning

confidence: 99%

“…Various genes, including UBE2T, were found to be associated with an unfavourable prognosis in each BrC subtype (54). High expression of UBE2T indicated a lower pathological complete remission rate in patients with TNBC after neoadjuvant chemotherapy, and in patients with luminal BrC with tumor recurrence within 5 years after endocrine therapy or chemotherapy (96).…”

Section: Expression Of Ube2t In Cancermentioning

confidence: 99%

See 1 more Smart Citation

Diverse roles of UBE2T in cancer (Review)

Yan

et al. 2023

Oncol Rep

View full text Add to dashboard Cite

As a leading cause of mortalities worldwide, cancer results from accumulation of both genetic and epigenetic alterations. Disruption of epigenetic regulation in cancer, particularly aberrant ubiquitination, has drawn increasing interest in recent years. The present study aimed to review the roles of ubiquitin-conjugating enzyme E2 T (UBE2T) and its associated pathways in the pathogenesis of pan-cancer, and the development of small-molecule modulators to regulate ubiquitination for treatment strategies. The current study comprehensively investigated the expression landscape and functional significance of UBE2T, as well as its correlation with cancer cell sensitivity to chemotherapy/radiotherapy. Multiple levels of evidence suggested that aberrant UBE2T played important roles in pan-cancer. Information was collected from 16 clinical trials on ubiquitin enzymes, and it was found that these molecules had an important role in the ubiquitin-proteasome system. Further studies are necessary to explore their feasibility and effectiveness as diagnostic and prognostic biomarkers, or as up/down-stream and therapeutic targets for cancer treatment.

show abstract

Section: Ube2tmentioning

confidence: 99%

Section: Expression Of Ube2t In Cancermentioning

confidence: 99%

Diverse roles of UBE2T in cancer (Review)

Yan

et al. 2023

Oncol Rep

View full text Add to dashboard Cite

show abstract

YWHAZ gene contributes to the radioresistance of oral squamous cell carcinoma cells

Hu,

Chen,

Chen

et al. 2024

Radiation Medicine and Protection

View full text Add to dashboard Cite

Genomic crossroads between non-Hodgkin’s lymphoma and common variable immunodeficiency

et al. 2022

Self Cite

View full text Add to dashboard Cite

Common variable immunodeficiency (CVID) represents the largest group of primary immunodeficiencies that may manifest with infections, inflammation, autoimmunity, and cancer, mainly B-cell non-Hodgkin’s lymphoma (NHL). Indeed, NHL may result from chronic or recurrent infections and has, therefore, been recognized as a clinical phenotype of CVID, although rare. The more one delves into the mechanisms involved in CVID and cancer, the stronger the idea that both pathologies can be a reflection of the same primer events observed from different angles. The potential effects of germline variants on specific somatic modifications in malignancies suggest that it might be possible to anticipate critical events during tumor development. In the same way, a somatic alteration in NHL could be conditioning a similar response at the transcriptional level in the shared signaling pathways with genetic germline alterations in CVID. We aimed to explore the genomic substrate shared between these entities to better characterize the CVID phenotype immunodeficiency in NHL. By means of an in-silico approach, we interrogated the large, publicly available datasets contained in cBioPortal for the presence of genes associated with genetic pathogenic variants in a panel of 50 genes recurrently altered in CVID and previously described as causative or disease-modifying. We found that 323 (25%) of the 1,309 NHL samples available for analysis harbored variants of the CVID spectrum, with the most recurrent alteration presented in NHL occurring in PIK3CD (6%) and STAT3 (4%). Pathway analysis of common gene alterations showed enrichment in inflammatory, immune surveillance, and defective DNA repair mechanisms similar to those affected in CVID, with PIK3R1 appearing as a central node in the protein interaction network. The co-occurrence of gene alterations was a frequent phenomenon. This study represents an attempt to identify common genomic grounds between CVID and NHL. Further prospective studies are required to better know the role of genetic variants associated with CVID and their reflection on the somatic pathogenic variants responsible for cancer, as well as to characterize the CVID-like phenotype in NHL, with the potential to influence early CVID detection and therapeutic management.

show abstract

Genomic Correlates of DNA Damage in Breast Cancer Subtypes

Cited by 3 publications

References 51 publications

Diverse roles of UBE2T in cancer (Review)

Diverse roles of UBE2T in cancer (Review)

YWHAZ gene contributes to the radioresistance of oral squamous cell carcinoma cells

Genomic crossroads between non-Hodgkin’s lymphoma and common variable immunodeficiency

Contact Info

Product

Resources

About