“…Out of the approximately 40 E2 enzymes in humans, UBE2T has emerged as a promising target for drug discovery because of its linkage with a variety of diseases. It is a key component of the Fanconi anemia (FA) pathway, where, along with the Really interesting new gene (RING)‐type E3 ligase FA complementation group L (FANCL), it is responsible for catalyzing the monoubiquitylation of the FANCI/FA group D2 protein (FANCD2) complex (Ma et al, 2023; Machida et al, 2006). The FA pathway is indispensable for the repair of DNA interstrand crosslinks (Ceccaldi et al, 2016; D'Andrea & Grompe, 2003), and its dysregulation has been linked to chemotherapy resistance, where cancer cells can overcome drug‐induced DNA interstrand crosslink formation.…”