Genomic Comparison of Adenovirus Type 3 Isolates from Patients with Acute Conjunctivitis in Japan, Australia, and the Philippines

Guo, Deng Fu; Shibata, Riri; Shinagawa, Morikazu; Sato, Gihei; Aoki, Koki; Sawada, H

doi:10.1111/j.1348-0421.1988.tb01444.x

Cited by 18 publications

(20 citation statements)

References 25 publications

(23 reference statements)

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“…At the University of Iowa's CEID, viral DNA was extracted from submitted specimens or cultures, and analyzed according to published procedures to determine adenovirus type and genotype [Adrian et al, 1989; Arens and Dilworth, 1988; Golovina et al, 1991; Guo et al, 1988; Li and Wadell, 1988; Lu and Erdman, 2006]. …”

Section: Methodsmentioning

confidence: 99%

Adenovirus type 3 outbreak in connecticut associated with a novel variant

Landry

Lebeck

Capuano

et al. 2009

Journal of Medical Virology

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An adenovirus outbreak occurred in New Haven, Connecticut in 2006-2007. Molecular typing revealed a 2-fold increase in adenovirus type 3 infections. Restriction enzyme analysis indicated that the CT outbreak was largely due to a marked increase in the novel Ad3a51 strain. This outbreak represents the first detection of Ad3a51 in the United States. While most infections were mild, children under 3 were at increased risk for severe disease and one patient with underlying disease died. KeywordsAdenoviridae; Adenovirus; epidemiology; respiratory tract diseases; communicable diseases; infectious diseases; emerging; outbreak Adenovirus infections are associated with a variety of clinical syndromes, and are usually selflimited. However, severe illness has been reported, especially in military recruits and compromised hosts, but has also been associated with new genomic variants [Kajon et al., 1990;Louie et al., 2008]. In order to investigate the current epidemiology of adenovirus infections in the United States, the University of Iowa Center for Emerging Infectious Diseases (CEID) and 22 US laboratories collaborated in a national surveillance program for emerging adenovirus infections from July 2004 through April of 2007. Laboratories routinely sent adenovirus-positive clinical specimens to the University of Iowa where the specimens were sequence typed using a hexon gene typing strategy [Lu and Erdman, 2006]. The collaboration resulted in the characterization of more than 3000 clinical adenovirus isolates. In November 2006, the Clinical Virology Laboratory at Yale New Haven Hospital (YNHH) in New Haven, Connecticut, experienced a marked increase in the number of clinical specimens that were adenovirus positive. This report summarizes an investigation into this increase. Methods Patient samplesSamples were submitted to clinical laboratories for diagnostic testing and were not solicited for the purposes of the study. Specimens positive for adenovirus by direct fluorescent antibody staining (DFA), PCR, other rapid test, or culture were sent to the University of Iowa from 22 participating laboratories, including 14 civilian and 8 military sites, for typing and further analysis. Prior to participation, the study was approved by each institution's Institutional Review Board. Clinical informationLimited demographic and clinical data was also submitted by each laboratory: collection date, collection site, specimen source, patient birth date, gender, hospitalized when specimen was collected, and if the subject had received a cellular or solid organ transplant during the previous six months. Because of their risk for severe disease, additional information was obtained from adenovirus patients <7 yrs of age or who had received a transplant procedure within six months of their adenovirus detection: race and ethnicity, clinical presentation, hospitalization, intensive care, disposition, cancer, and chronic disease.After recognition of the CT adenovirus outbreak, supplemental clinical information was obtained on the 218 Ad3...

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Section: Methodsmentioning

confidence: 99%

Adenovirus type 3 outbreak in connecticut associated with a novel variant

Landry

Lebeck

Capuano

et al. 2009

Journal of Medical Virology

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“…Ad3 and Ad7 are excreted in faeces of patients with respiratory illness for a long time after the disease Fox et al, 19691, and they can also be shed by healthy subjects [Galbraith, 1965;Gomes et al, 19891. Genetic diversity of Ads can be evaluated by DNA restriction analysis of strains isolated from around the world. In this way, a number of genome types serologically identical to the prototype but different in their DNA restriction patterns have been reported for Ad3 [Adrian et al, 1989b;Arens and Dilworth, 1988;Bailey and Richmond, 1986;Gomes et al, 1989;Guo et al, 1988;Li and Wadell, 1988;O'Donnell et al, 19861 and Ad7 [Adrian et al, 1989a;Arens and Dilworth, 1988;Bailey and Richmond, 1986;Kannemeyer et al, 1988;Li and Wadell, 19861. An intermediate Ad3-7 strain has also been characterized [Adrian and Wigand, 19861. We now report the characterization of three genome types of Ad3 and one of Ad7 isolated in South America and present a number of restriction maps of their genomes.…”

Section: Introductionmentioning

confidence: 96%

Restriction site mapping of four genome types of adenovirus types 3 and 7 isolated in South America

Niel

Moraes

Mistchenko

et al. 1991

Journal of Medical Virology

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New genome types of Ad3 and Ad7 were found among adenovirus (Ad) strains isolated from stools of children during epidemiological surveys made in São Paulo, Brazil, and Buenos Aires, Argentina. These were characterized by DNA analysis with 11 restriction endonucleases and showed a number of new restriction patterns, notably for BamHI, BcII, BgIII, HindIII, KpnI, and SmaI. Restriction maps of the genome types, named Ad3e1, Ad3e2, Ad3h, and Ad7h, were constructed and compared with those of Ad3p and Ad7p.

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“…Representative patterns of DNA from Ad3 isolates cut with BamHI, Bgl II, Hind III, and Sma I are shown in Figure 1. Identical restriction patterns were obtained with 47 isolates and these were identified as Ad3f [Guo et al, 1988]. Eight isolates produced unique restriction profiles.…”

Section: Genotyping Of Ad3 Isolatesmentioning

confidence: 81%

“…The Ad3 genotype recovered from most conjunctivitis cases in Japan in 1983 was Ad3g [Guo et al, 1988]; however, this changed to Ad3f in 1986 [Itakura et al, 1990]. In 1990, all 45 isolates of Ad3 in Japan from patients with acute conjunctivitis were Ad3f [Shiao et al, 1996].…”

Section: Introductionmentioning

confidence: 99%

Four new genotypes of adenovirus type 3 isolated from patients with conjunctivitis in Japan

et al. 1999

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Adenovirus type 3 (Ad3) was the most frequently isolated serotype from patients with conjunctivitis during the period from 1989 to 1991 in Japan. All Ad3 strains isolated in 1990 had an identical genotype, Ad3f. However, in 1992, the predominant serotype was replaced by Ad4. The genome type was examined to determine whether genetic changes existed in Ad3 isolates in 1992. Ad3 isolated from 55 patients with acute conjunctivitis during the period from June 1992 to February 1993 in Japan was assessed by genome typing with restriction endonucleases BamH I, Bgl II, Hind III, and Sma I recognizing 6-base-pair sequences. The emergence of four new genotypes of Ad3 was identified; one with a new Bam HI site (one isolate), one with a new Bgl II site (two isolates), one with a new Hind III site (three isolates) and one with a new Sma I site (two isolates). This study demonstrates that the emergence of a new genotype of Ad3 may contribute to the replacement of the predominant serotype associated with adenovirus conjunctivitis in Japan.

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Genomic Comparison of Adenovirus Type 3 Isolates from Patients with Acute Conjunctivitis in Japan, Australia, and the Philippines

Abstract: A total of 53 Ad3

Cited by 18 publications

References 25 publications

Adenovirus type 3 outbreak in connecticut associated with a novel variant

Adenovirus type 3 outbreak in connecticut associated with a novel variant

Restriction site mapping of four genome types of adenovirus types 3 and 7 isolated in South America

Four new genotypes of adenovirus type 3 isolated from patients with conjunctivitis in Japan

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