Genomic and Biologic Characteristics of SARS-CoV-2 and Other Coronaviruses

Hoşbul, Tuğrul; Şahiner, Fatih

doi:10.46683/jmvi.2020.2

Cited by 2 publications

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References 4 publications

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“…2 This novel coronavirus causes severe respiratory disease in humans, similar to two other recent zoonotic respiratory coronaviruses: SARS-CoV and Middle East respiratory syndrome-related coronavirus (MERS-CoV). 3,4 In SARS-CoV-2 infections, in addition to local pathological changes associated with cellular damage occurring in viral replication regions, some cases also present with secondary changes associated with the excessive immune response (cytokine storm), which has been directly related to mortality and morbidity. [5][6][7] Hyperinflammation, hemophagocytosis, thrombocytopenia, lymphopenia, and relativehigher monocyte-neutrophil levels are common findings in SARS-CoV-2 infections.…”

Section: Introductionmentioning

confidence: 99%

Does COVID-19 cause an increase in spleen dimensions? Possible effects of immune activation, hematopoietic suppression and microthrombosis

et al. 2021

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Purpose To radiologically examine how the spleen size, which has important functions in hematological and immunological balance, is affected in COVID-19. Methods Between July 1 and August 31, 2020, consecutive patients diagnosed with COVID-19 were analyzed. Among these patients, those who underwent chest computed tomography (CT) examination at the time of presentation, patients with follow-up CT due to clinical deterioration were included in the study. The CTs of the patients were evaluated in terms of spleen size and volume. Results A total of 160 patients (88 females, 55%) were included in the study. The mean time between the initial and follow-up CT was 7.2 ± 2.8 days. The splenic volume (244.3 ± 136.7 vs. 303.5 ± 156.3 cm 3 ) and splenic index (421.2 ± 235.5 vs. 523.2 ± 269.4 cm 3 ) values were significantly higher in the follow-up CT compared to the initial CT (p < 0.001). The increase in the splenic volume and splenic index values was 59.2 ± 52.4 cm 3 and 101.9 ± 90.3 cm 3 (p < 0.001), respectively. The COVID-19 severity score was significantly higher in the follow-up CT compared to the initial CT (3.7 ± 4.2 vs. 12.5 ± 5.7, respectively; p < 0.001). The spleen width measured separately on the initial and follow-up CTs showed a highest positive correlation (r = 0.982, p < 0.001). Conclusion Our study indicates that spleen size increases slightly-moderately in the first stages of the infection, and this increase is correlated with the COVID-19 severity score calculated on the chest CT data, and in this respect, it is similar to infections presenting with cytokine storm.

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Section: Introductionmentioning

confidence: 99%

Does COVID-19 cause an increase in spleen dimensions? Possible effects of immune activation, hematopoietic suppression and microthrombosis

et al. 2021

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Biyokimyasal Açıdan Koronavirüs

Güven

2021

Sinop Üniversitesi Fen Bilimleri Dergisi

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The purpose of this study is; to give information about the biological structure, metabolism and interaction of the Covid-19 agent virus with the defense system; to reveal the relationship between biochemical blood values and the defense system in Covid-19 cases and to update the data on preventing the damage that the virus may cause, in line with scientific developments. Relevant articles found by searching the keywords "SARS-CoV-2" and "Coronavirus" in Pubmed, Web of Science and Google Scholar databases and Google Search Engine were included in the study. This virus, called SARS-CoV-2, which originated in Vuhan, China and caused the disease called Covid-19, spread to almost all countries of the world and caused a high number of deaths in a very short time. Using the virus RNA, the infected cell begins to produce proteins that will keep the immune system at bay and help create new copies of the virus. For this reason, monitoring the disease and sharing information all over the world, epidemiological contact history, clinical features, biochemical tests in all blood and urine and other conditions are important evaluations for the treatments of the patient. It is imperative to follow the global situation and to make correct decisions according to the changes in epidemiology and to update the information of employees.

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Genomic and Biologic Characteristics of SARS-CoV-2 and Other Coronaviruses

Cited by 2 publications

References 4 publications

Does COVID-19 cause an increase in spleen dimensions? Possible effects of immune activation, hematopoietic suppression and microthrombosis

Does COVID-19 cause an increase in spleen dimensions? Possible effects of immune activation, hematopoietic suppression and microthrombosis

Biyokimyasal Açıdan Koronavirüs

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