Genomic–anatomic evidence for distinct functional domains in hippocampal field CA1

Abstract

genetics ͉ genomics ͉ hippocampus ͉ learning and memory ͉ neuroanatomy

Updating hippocampal representations: CA2 joins the circuit

“…While standard extracellular recording techniques preclude accurate discrimination of these cell subclasses to address possible differential functions, combinations of emerging genetic, optical and in vivo intracellular recording techniques may soon make this possible [105][106][107][108]. This study also determined that gene expression patterns across connected structures were similar [104]; for example the genetic profile of a ventral CA1 neuron was more similar to neurons in the emotional regions of the brain (amygdala, lateral septum, ventral subiculum), than that of a dorsal CA1 neuron.…”

“…A recent study [104] suggests that the neurons in the densely-packed superficial pyramidal layer are distinct from the sparser deep layers in dorsal CA1 [104]. While standard extracellular recording techniques preclude accurate discrimination of these cell subclasses to address possible differential functions, combinations of emerging genetic, optical and in vivo intracellular recording techniques may soon make this possible [105][106][107][108].…”

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

“…Nevertheless, it is clear the HPF has a role in the control of behavior, and in this role it appears to participate, interrelatedly, in mnemonic processes and the processing and integration of multisensory locational ("spatial") and affective ("emotional") information (Hirsh, 1974;Eichenbaum, 2000;Dolan, 2002;Holscher, 2003;Bannerman et al, 2004;Erdi et al, 2005). In addition, recent genetic analysis of Ammon's horn in the mouse has materially increased our understanding of HPF organization (Thompson et al, 2008;Dong et al, 2009;Fanselow and Dong, 2010). With reference to a genome-wide atlas of gene expression in the adult mouse brain (Lein et al, 2007), Dong and colleagues (2009) identified field CA1-expressed genes that delineate several molecularly and spatially distinct populations of field CA1 neurons; moreover, they identified correlations between those field CA1 neuron populations and their also genetically distinct subcortical axonal target regions (Dong et al, 2009); similar findings have been described for field CA3 (Thompson et al, 2008).…”

“…In addition, recent genetic analysis of Ammon's horn in the mouse has materially increased our understanding of HPF organization (Thompson et al, 2008;Dong et al, 2009;Fanselow and Dong, 2010). With reference to a genome-wide atlas of gene expression in the adult mouse brain (Lein et al, 2007), Dong and colleagues (2009) identified field CA1-expressed genes that delineate several molecularly and spatially distinct populations of field CA1 neurons; moreover, they identified correlations between those field CA1 neuron populations and their also genetically distinct subcortical axonal target regions (Dong et al, 2009); similar findings have been described for field CA3 (Thompson et al, 2008).…”

“…The recent genetic analyses (Dong et al, 2009;Fanselow and Dong, 2010) are generally consistent with, and provide a firmer basis for, a hypothesized dorsal/septal (posterior in primates) to ventral/temporal (anterior in primates) functional differentiation along the longitudinal axis of the hippocampal region, in which the dorsal and ventral differentiations have differing primary roles in the processing of (very broadly) nonaffective (dorsal differentiation) and affective (ventral differentiation) information (Moser and Moser, 1998). In addition, they show that the intermediate third of the hippocampal region and subiculum (which project massively to the LHAjd and LHAjp-present data and Kishi et al, 2000) are genetically distinct as well (Fanselow and Dong, 2010).…”