Identification of <scp>FXYD6</scp> as the novel biomarker for glioma based on differential expression and <scp>DNA</scp> methylation

Hou, Weiliang; Cai, Jing; Shen, Pei; Zhang, Shuo; Xiao, Siyu; You, Pu; Tong, Yusheng; Li, Kaicheng; Qi, Zengxin; Luo, Hao

doi:10.1002/cam4.6752

Cited by 3 publications

(2 citation statements)

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“…Notably, it is overexpressed in a variety of cancer cells [ 124 ]. FXYD6 is expressed in widely diverse normal tissues and organs and highly expressed in the nervous system [ 125 ]. FXYD7 is expressed in the brain [ 126 ].…”

Section: Nka’s Role As An Electrogenic Pumpmentioning

confidence: 99%

“…In Renal Cell Carcinoma, high expression of FXYD3 has been linked to poor prognosis [ 131 ]. Glioblastoma exhibits downregulation of FXYD6, suggesting its potential as a biomarker for the diagnosis and prognosis of glioma [ 125 ]. Moreover, gene expression analysis indicates FXYD5 overexpression in short-term survivors of high-grade serous ovarian cancer compared to long-term survivors, highlighting its prognostic and predictive significance [ 132 ].…”

Section: Nka’s Role As An Electrogenic Pumpmentioning

confidence: 99%

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Na+/K+-ATPase: More than an Electrogenic Pump

Contreras,

Torres-Carrillo,

Flores-Maldonado

et al. 2024

IJMS

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The sodium pump, or Na+/K+-ATPase (NKA), is an essential enzyme found in the plasma membrane of all animal cells. Its primary role is to transport sodium (Na+) and potassium (K+) ions across the cell membrane, using energy from ATP hydrolysis. This transport creates and maintains an electrochemical gradient, which is crucial for various cellular processes, including cell volume regulation, electrical excitability, and secondary active transport. Although the role of NKA as a pump was discovered and demonstrated several decades ago, it remains the subject of intense research. Current studies aim to delve deeper into several aspects of this molecular entity, such as describing its structure and mode of operation in atomic detail, understanding its molecular and functional diversity, and examining the consequences of its malfunction due to structural alterations. Additionally, researchers are investigating the effects of various substances that amplify or decrease its pumping activity. Beyond its role as a pump, growing evidence indicates that in various cell types, NKA also functions as a receptor for cardiac glycosides like ouabain. This receptor activity triggers the activation of various signaling pathways, producing significant morphological and physiological effects. In this report, we present the results of a comprehensive review of the most outstanding studies of the past five years. We highlight the progress made regarding this new concept of NKA and the various cardiac glycosides that influence it. Furthermore, we emphasize NKA’s role in epithelial physiology, particularly its function as a receptor for cardiac glycosides that trigger intracellular signals regulating cell–cell contacts, proliferation, differentiation, and adhesion. We also analyze the role of NKA β-subunits as cell adhesion molecules in glia and epithelial cells.

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Section: Nka’s Role As An Electrogenic Pumpmentioning

confidence: 99%