Genomic analysis of intestinal flora and liver genes in mice with circadian rhythm disorders fed with flavonoids from Sedum aizoon L.

Zhao, Ke; Ge, Qingqing; Zhang, Xin; Shao, Xingfeng; Wei, Yingying; Wang, Hongfei; Xu, Feng

doi:10.1016/j.fbio.2022.102067

Cited by 6 publications

(5 citation statements)

References 39 publications

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“…Analysis of the plant extract showed kaempferol-3-O-β-glucuronide as the predominant flavonoid, with kaempferol-3-O-α-L-rhamnopyranoside, quercetin and quercetin-3-O-glucoside (isoquer citrin) found in varying proportions [46]. Other studies investigating the effect of flavo noids on circadian rhythms in different mice models showed similar outcomes [47][48][49][50] Most flavonoids have poor bioavailability in mammals, and merely pass through the di gestive tract to be metabolised by intestinal microbes in the colon. Therefore, some author leave open the option that flavonoids may not directly affect mammalian physiology bu do so indirectly by altering the gut microbiota which then, in turn, produce metabolite that affect the mammalian circadian system [46,50].…”

Section: Effects Of Natural Products On Circadian Rhythmmentioning

confidence: 98%

“…Analysis of the plant extract showed kaempferol-3-O-β-glucuronide as the predominant flavonoid, with kaempferol-3-O-α-Lrhamnopyranoside, quercetin and quercetin-3-O-glucoside (isoquercitrin) found in varying proportions [46]. Other studies investigating the effect of flavonoids on circadian rhythms in different mice models showed similar outcomes [47][48][49][50]. Most flavonoids have poor bioavailability in mammals, and merely pass through the digestive tract to be metabolised by intestinal microbes in the colon.…”

Section: Effects Of Natural Products On Circadian Rhythmmentioning

confidence: 99%

“…Most flavonoids have poor bioavailability in mammals, and merely pass through the digestive tract to be metabolised by intestinal microbes in the colon. Therefore, some authors leave open the option that flavonoids may not directly affect mammalian physiology but do so indirectly by altering the gut microbiota which then, in turn, produce metabolites that affect the mammalian circadian system [46,50]. The concept of the gut-brain axis is intriguing and attracting increasing interest, though much still remains to be further explored.…”

Section: Effects Of Natural Products On Circadian Rhythmmentioning

confidence: 99%

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Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome

et al. 2022

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The importance of the circadian clock in maintaining human health is now widely acknowledged. Dysregulated and dampened clocks may be a common cause of age-related diseases and metabolic syndrome Thus, circadian clocks should be considered as therapeutic targets to mitigate disease symptoms. This review highlights a number of dietary compounds that positively affect the maintenance of the circadian clock. Notably the polymethoxyflavone nobiletin has shown some encouraging results in pre-clinical experiments. Although many more experiments are needed to fully elucidate its exact mechanism of action, it is a promising candidate with potential as a chronotherapeutic agent.

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Section: Effects Of Natural Products On Circadian Rhythmmentioning

confidence: 98%

Section: Effects Of Natural Products On Circadian Rhythmmentioning

confidence: 99%

Section: Effects Of Natural Products On Circadian Rhythmmentioning

confidence: 99%

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Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome

et al. 2022

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“…The gut microbiota has been identified as an environmental factor that significantly impacts digestion absorption and physiological metabolism in animals (4,5). Its composition and proportions are dynamic, depending on both internal and external factors of the host (6).…”

Section: Introductionmentioning

confidence: 99%

Effects of simulated winter short photoperiods on the microbiome and intestinal metabolism in Huanghe carp (Cyprinus carpio haematopterus)

Wang,

Su,

Dong

et al. 2024

Front. Endocrinol.

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ObjectiveAs one of the most important environmental signals, photoperiod plays a crucial role in regulating the growth, metabolism, and survival of organisms. The photoperiod shifts with the transition of the seasons. The difference in photoperiod between summer and winter is the greatest under natural conditions. However, the effect of photoperiod on Huanghe carp (Cyprinus carpio haematopterus) was paid little attention. We investigated the impact of artificial manipulation of seasonal photoperiod on Huanghe carp by integrating growth performance, intestinal flora, and intestinal metabolome.MethodWe conducted an 8-week culture experiment with summer photoperiod (14 h light:10 h dark, n = 60) as the control group and winter photoperiod (10 h light:14 h dark, n = 60) based on the natural laws.ResultsWinter photoperiod provokes significant weight increases in Huanghe carp. The altered photoperiod contributed to a significant increase in triglyceride and low-density lipoprotein cholesterol levels and the gene expressions of lipid metabolism in the intestine of Huanghe carp. 16s rDNA sequencing revealed that winter photoperiod diminished intestinal flora diversity and altered the abundance. Specifically, the relative abundances of Fusobacteria and Acidobacteriota phyla were higher but Proteobacteria, Firmicutes, and Bacteroidetes phyla were reduced. Analogously, photoperiodic changes induced a significant reduction in the Pseudomonas, Vibrio, Ralstonia, Acinetobacter, and Pseudoalteromonas at the genus level. Additionally, metabolomics analysis showed more than 50% of differential metabolites were associated with phospholipids and inflammation. Microbiome and metabolome correlation analyses revealed that intestinal microbe mediated lipid metabolism alteration.ConclusionThe winter photoperiod induced intestinal flora imbalance and lipid metabolism modification, ultimately affecting the growth of Huanghe carp. This study provides new insights into the effects of seasonal photoperiodic alteration on the well-being of fish.

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“…Sedum aizoon L. was widely used in folk medicine to prevent and treat hyperlipidemia, hypertension, hemorrhage, palpitation [5] , and coronary heart disease [6] . The bioactive chemical composition of Sedum aizoon L. includes phenols [7] , flavonoids [8] , polysaccharides [9] , alkaloids, and triterpenoids [10] . Among them, flavonoids and phenolic acid components are the main active components in Sedum aizoon L. [11] such as gallic acid, quercetin, kaempferol, myricetrin, luteolin, etc.…”

Section: Introductionmentioning

confidence: 99%

Optimization of enzymatic-assisted ultrasonic extraction process of total flavonoids from Sedum aizoon L. and its antioxidant activity

Yin,

Batbatan

2023

BIO Web Conf.

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In order to optimize the enzymatic-assisted ultrasonic extraction method of total flavonoids from Sedum aizoon L., the effects of solid-liquid ratio, ethanol concentration, extraction temperature, extraction time, and ultrasound power on the extraction rate were investigated by single factor experiment. The optimum technological conditions for enzymatic-assisted ultrasonic extraction of total flavonoids from Sedum aizoon L. were as follows: solid-liquid ratio 1:55 (g/mL), ethanol volume fraction 60%, extraction temperature 45°C, extraction time 2 5 min, and ultrasound power 150 W. Under these conditions, the extraction rate of total flavonoids from Sedum aizoon L. could reach 10.77%. The antioxidant activity of flavonoids from Sedum aizoon L. was positively correlated with the concentration, and the greater the concentration, the stronger the antioxidant capacity. At a concentration of 0.96 mg/mL, the scavenging rate of the DPPH• radical reached 67.5%. The scavenging rate of the ABTs+• radical reached 55.8% at a concentration of 1.92 mg/mL.

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Genomic analysis of intestinal flora and liver genes in mice with circadian rhythm disorders fed with flavonoids from Sedum aizoon L.

Cited by 6 publications

References 39 publications

Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome

Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome

Effects of simulated winter short photoperiods on the microbiome and intestinal metabolism in Huanghe carp (Cyprinus carpio haematopterus)

Optimization of enzymatic-assisted ultrasonic extraction process of total flavonoids from Sedum aizoon L. and its antioxidant activity

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