Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome

Ambe, Gael N. N. Neba; Breda, Carlo; Bhambra, Avninder S.; Arroo, R. R. J.

doi:10.3390/molecules27227727

Cited by 8 publications

(10 citation statements)

References 91 publications

(114 reference statements)

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“…It can be concluded from the few studies presented that intaking a high-energy source at nighttime and its diet component may contribute to impaired energy and glucose metabolism and reproductive hormone disruption during pregnancy ( 126 , 127 ). In pregnant animals, it was found that disturbed intake timing, or feeding (during the day period by nocturnal rodents), gave rise to an irregular circadian rhythm in the mother and fetus ( 127 ) and was capable of altering the microbiota profiles to give rise to metabolic disorders ( 128 ). However, studies that translate these mechanisms to pregnant women have not yet been carried out.…”

Section: Enteroendocrine Hormones and Pregnancymentioning

confidence: 99%

“…Some of the potentials as chronotherapeutic agents are flavonoids. Nobiletin, a polymethoxy flavone obtained from dried citrus peel, known as Citri Reticulatae Pericarpium fruit, was identified as a particularly effective clock amplitude-enhancing small molecule and can directly affect the mammalian circadian system ( 128 – 130 ). Time-restricted feeding partially restores diurnal rhythms of the ileal microbiome ( 131 ).…”

Section: Enteroendocrine Hormones and Pregnancymentioning

confidence: 99%

See 1 more Smart Citation

Circadian hormone secretion of enteroendocrine cells: implication on pregnancy status

Homeida

Al-Suhaimi

2023

Front. Endocrinol.

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The timing of food intake is a key cue for circadian rhythms in humans and animals. In response to food intake, gut hormones called incretin are produced by intestinal enteroendocrine cells in a circadian rhythm that stimulates insulin secretion and regulates body weight and energy expenditure. Pregnancy is associated with the expansion of β cells, the risk of gestational diabetes mellitus, and excessive weight gain. The timing of food intake is a good way to address metabolic complications during pregnancy. The current review focuses on the circadian rhythms and biological actions of enteroendocrine hormones and their associations with pregnancy status, specifically topics like food intake and gut circadian rhythms, the circadian secretion of enteroendocrine peptides, and the effects of these factors during pregnancy.

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Section: Enteroendocrine Hormones and Pregnancymentioning

confidence: 99%

Section: Enteroendocrine Hormones and Pregnancymentioning

confidence: 99%

Circadian hormone secretion of enteroendocrine cells: implication on pregnancy status

Homeida

Al-Suhaimi

2023

Front. Endocrinol.

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“…Several in vitro and in vivo studies have shown that flavonoids, especially flavanones, the main class of flavonoids in citrus extracts, such as naringin and naringenin [ 22 , 28 ], possess antiproliferative, anti-inflammatory, and pro-apoptotic properties [ 29 , 30 , 31 , 32 , 33 , 34 ]. Other compounds found in citrus fruits that have demonstrated potential anticancer effects include quercetin [ 15 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ], hesperidin [ 42 , 43 , 44 ], hesperetin [ 45 , 46 ], polymethoxyflavones [ 47 , 48 , 49 ], eriodyctiol [ 50 , 51 ], bergapten [ 52 , 53 ], tangeretin [ 54 , 55 ], auraptene [ 56 , 57 , 58 ], limonin [ 59 ], naringenin [ 60 , 61 , 62 , 63 , 64 , 65 ], and naringin [ 66 , 67 , 68 ], as shown in ( Table 1 ). These findings suggest a potential role for flavonoids in cancer therapy, including breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer

et al. 2023

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Citrus (genus Citrus L.) fruits are essential sources of bioactive compounds with antioxidant properties, such as flavonoids. These polyphenolic compounds are divided into subclasses, in which flavanones are the most prominent. Among them, naringenin and hesperidin are emerging compounds with anticancer potential, especially for breast cancer (BC). Several mechanisms have been proposed, including the modulation of epigenetics, estrogen signaling, induction of cell death via regulation of apoptotic signaling pathways, and inhibition of tumor invasion and metastasis. However, this information is sparse in the literature and needs to be brought together to provide an overview of how naringenin and hesperidin can serve as therapeutic tools for drug development and as a successful co-adjuvant strategy against BC. This review detailed such mechanisms in this context and highlighted how naringenin and hesperidin could interfere in BC carcinogenesis and be helpful as potential alternative therapeutic sources for breast cancer treatment.

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“…Nobiletin, an important component of polymethoxylated flavones isolated from citrus fruit peels, has been extensively investigated in various diseases, such as diabetes, cancer, nonalcoholic fatty liver disease, and sepsis (7). Recently, nobiletin has received increased attention because of its superior physical functions, which exhibit minimal toxicity and a variety of pharmacological benefits, including anti-inflammatory, anti-oxidant stress, anti-cancer, and anti-diabetic effects (8,9).…”

Section: Introductionmentioning

confidence: 99%

Nobiletin ameliorates heatstroke-induced acute lung injury by inhibiting ferroptosis via p53/SLC7A11 pathway

Chen,

Xie,

Peng

et al. 2023

Shock

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The molecular mechanism for nobiletin’s protective effect against heatstroke-induced acute lung injury (HS-ALI) remains largely unknown. Previous research has demonstrated that ferroptosis is an important pathogenic event in HS-ALI. Nobiletin is a natural polymethoxylated flavonoid. Herein, we investigated the potential contribution of nobiletin to HS-ALI by inhibiting ferroptosis. Heat stress was used to induce HS-ALI in mice, and MLE-12 cells were stimulated by heat stress in vitro. Nobiletin was administrated by gavage for 2 hours before HS induction. Biochemical kits, immunofluorescence staining, and western blotting were performed on the markers of ferroptosis. Our results showed that nobiletin administration significantly attenuated HS-induced lung injury and ferroptosis. Moreover, nobiletin pretreatment significantly reversed HS-induced p53 upregulation in vivo and in vitro. Pretreatment with a p53 agonist, Tenovin-6 partly abolished the protective effect of nobiletin in mice with HS-ALI. Meanwhile, p53 knockdown significantly increased GPX4 and SLC7A11 expression levels compared to the HS group in HS-induced MLE-12 cells. Subsequently, nobiletin ameliorated HS-induced MLE-12 cells ferroptosis by activating the SLC7A11/GPX4 pathway, while p53 overexpression effectively abolished the protective effect of nobiletin. Taken together, our findings reveal that nobiletin attenuates HS-ALI by inhibiting ferroptosis through the p53/SLC7A11 pathway, indicating it to be a potential therapeutic agent for HS-ALI prevention and treatment.

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Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome

Cited by 8 publications

References 91 publications

Circadian hormone secretion of enteroendocrine cells: implication on pregnancy status

Circadian hormone secretion of enteroendocrine cells: implication on pregnancy status

Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer

Nobiletin ameliorates heatstroke-induced acute lung injury by inhibiting ferroptosis via p53/SLC7A11 pathway

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