Genomic Analysis of a New Mammalian Distal-less Gene: Dlx7

Nakamura, Shuji; Stock, David W.; Wydner, Karen L.; Bollekens, Jacques; Takeshita, Kenichi; Nagai, Brian M.; Chiba, Shigeru; Kitamura, Toshio; Freeland, Thomas; Zhao, Zhiyong; Minowada, Jun; Lawrence, Jeanne B.; Weiss, Kenneth M.; Ruddle, Frank H.

doi:10.1006/geno.1996.0634

Cited by 74 publications

(68 citation statements)

References 3 publications

(4 reference statements)

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“…Human DLX4 and two other isoforms of this gene, DLX7 and BP1, have been identified [21,22,27]. BP1 and DLX7 [35] share almost complete sequence identity from nucleotides 565 to 1251 of BP1 (including their homeoboxes), and they map to the same chromosomal region, 17q21-22 [22]. A consensus binding site for DLX7 has not yet been determined; the DLX7 protein does bind to silencer I DNA, although it lacks repressor function [22].…”

Section: Discussionmentioning

confidence: 99%

Inhibition of β protein 1 expression enhances β-globin promoter activity and β-globin mRNA levels in the human erythroleukemia (K562) cell line

Zoueva¹,

Rodgers²

2004

Experimental Hematology

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Expression of globin genes within the β-globin cluster is regulated to produce different hemoglobin β chains during the embryonic (ε), fetal (γ), and adult (β) stages of erythroid cell development. Each distinct hemoglobin tetramer exhibits a different affinity for oxygen, resulting in optimal O 2 / CO 2 exchange between the developing fetus and mother. Thus, developmentally appropriate transcriptional activation of each different β chain is essential. This is achieved by the binding of transcriptional activator proteins to the successive β-chain promoters; the locus control region (LCR), consisting of five DNase I-hypersensitive sites (HS1-5) located from 8 to 22 kbp 5′ to the ε-globin gene, also Offprint requests to:

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Section: Discussionmentioning

confidence: 99%

Inhibition of β protein 1 expression enhances β-globin promoter activity and β-globin mRNA levels in the human erythroleukemia (K562) cell line

Zoueva¹,

Rodgers²

2004

Experimental Hematology

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“…The HOX genes are clustered on four chromosomes, and the DLX genes are located in pairs on the same chromosomes. 3,4,12,36 BP1 is situated at the 3Ј end of the HOXB cluster on chromosome 17. 15 HOXB genes are preferentially expressed in erythroid cells, including K562 and HEL cell lines.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to BP1, analyses of two other cDNAs are included in these experiments, DLX7 and DLX4. [12][13][14] BP1, DLX7 and DLX4 appear to represent isoforms (alternative splice variants) of a common gene. Evidence for this includes our observations that the three homeoboxes are identical and the cDNAs share sequence identity in other regions.…”

Section: Introductionmentioning

confidence: 99%

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BP1, a new homeobox gene, is frequently expressed in acute leukemias

Haga

et al. 2000

Leukemia

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Aberrant expression of homeobox genes has been described in primary leukemia blasts. We recently cloned a new cDNA, BP1, which is a member of the homeobox gene family. BP1 expression was investigated in bone marrow samples from acute myeloid leukemia (AML), acute T cell lymphocytic leukemia (ALL) and pre-B cell ALL. Expression levels of two apparent isoforms of BP1, DLX7 and DLX4, were measured in the same samples. They are weakly if at all detectable in normal bone marrow, PHA-stimulated T cells or B cells. BP1 RNA was highly expressed in 63% of AML cases, including 81% of the pediatric and 47% of the adult cases, and in 32% of T-ALL cases, but was not found in any of the pre-B ALL cases. Coexpression of BP1, DLX7 and DLX4 occurred in a significant number of leukemias. Our data, including co-expression of BP1 with c-myb and GATA-1, markers of early progenitors, suggest that BP1 expression occurs in primitive cells in AML. Analysis of CD34 + and CD34 − normal bone marrow cells revealed BP1 is expressed in CD34 − cells and virtually extinguished in CD34 + cells. Ectopic expression of BP1 in the leukemia cell line K562 increased clonogenicity, consistent with a role for BP1 in leukemogenesis. The presence of BP1 RNA in leukemic blasts may therefore be a molecular marker for primitive cells and/or may indicate that BP1 is an important upstream factor in an oncogenic pathway.

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“…This region of zebrafish linkage group 3 is syntenic to the human chromosome 17 region. Human fz2 maps by FISH to 17q21.1 (Zhao et al, 1995), human hoxB9 maps to 17q21-q22 (Acampora et al, 1989;Apiou et al, 1996;HUGO database), and human Dlx4, an ortholog of zebrafish Dlx8, maps to 17q21.33 (Nakamura et al, 1996;Stock et al, 1996). Thus, human frizzled-2 is likely to be the true ortholog of the zebrafish frizzled-2 gene.…”

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confidence: 99%