Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

Sakamoto, Yuma; Yamamoto, Takuaki; Sugano, Nobuhiko; Takahashi, Daisuke; Watanabe, Toshiyuki; Atsumi, Takashi; Nakamura, Junichi; Hasegawa, Yukiharu; Akashi, Koichi; Narita, Ichiei; Miyamoto, Takeshi; Takeuchi, Tsutomu; Ikari, Katsunori; Amano, Koichi; Fujie, Atsuhiro; Kubo, Toshikazu; Tada, Yutaka; Kaneuji, Ayumi; Nakamura, Hiroaki; Miyamura, Tomoya; Kabata, Tamon; Yamaji, Katsuhiko; Okawa, Takahiro; Sudo, Akihiro; Ohzono, Kenji; Tanaka, Yoshiya; Yasunaga, Yuji; Matsuda, Shinya; Imai, Yuuki; Akiyama, Masato; Kubo, Michiaki; Kamatani, Yoichiro; Iwamoto, Yukihide; Ikegawa, Shiro

doi:10.1038/s41598-017-14778-y

Cited by 23 publications

(5 citation statements)

References 63 publications

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“…An essential facet of executive control is response inhibition, which enables the suppression of inappropriate or no-longer relevant actions [ 43 , 44 ] and is facilitated through prefrontal cortical regions, including the inferior frontal gyrus (IFG) and the DLPFC [ 44 ]. Previous studies have observed sex-related differences in inhibition ability [ 6 , 26 – 29 , 45 ]. We have previously demonstrated in the context of the Stop-Signal Task that following practice, females learned to improve their response inhibition ability to a greater extent than males [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition

et al. 2021

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Context-dependent execution or inhibition of a response is an important aspect of executive control, which is impaired in neuropsychological and addiction disorders. Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) has been considered a remedial approach to address deficits in response control; however, considerable variability has been observed in tDCS effects. These variabilities might be related to contextual differences such as background visual-auditory stimuli or subjects' sex. In this study, we examined the interaction of two contextual factors, participants' sex and background acoustic stimuli, in modulating the effects of tDCS on response inhibition and execution. In a sham-controlled and cross-over (repeated-measure) design, 73 participants (37 females) performed a Stop-Signal Task in different background acoustic conditions before and after tDCS (anodal or sham) was applied over the DLPFC. Participants had to execute a speeded response in Go trials but inhibit their response in Stop trials. Participants' sex was fully counterbalanced across all experimental conditions (acoustic and tDCS). We found significant practice-related learning that appeared as changes in indices of response inhibition (stop-signal reaction time and percentage of successful inhibition) and action execution (response time and percentage correct). The tDCS and acoustic stimuli interactively influenced practice-related changes in response inhibition and these effects were uniformly seen in both males and females. However, the effects of tDCS on response execution (percentage of correct responses) were sex-dependent in that practice-related changes diminished in females but heightened in males. Our findings indicate that participants' sex influenced the effects of tDCS on the execution, but not inhibition, of responses.

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Section: Introductionmentioning

confidence: 99%

Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition

et al. 2021

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“…Genome-wide association studies of selected populations have identified several loci of interest, including clusters of variants near glutamate receptor genes in patients with ALL, 45 corticosteroid-induced osteonecrosis, 33 and several loci of unknown significance, which may be related to coagulation pathways, lipid metabolism, or alcohol drinking behavior. 46 …”

Section: Pathophysiology and Pathogenesismentioning

confidence: 99%

Osteonecrosis of the Femoral Head

George

Lane

2022

JAAOS Glob Res Rev

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Osteonecrosis of the femoral head is a progressive and debilitating condition with a wide variety of etiologies including trauma, steroid use, and alcohol intake. Diagnosis and staging are based on imaging including MRI at any stage and plain radiography in more advanced lesions. The only definitive treatment is total hip arthroplasty, although numerous treatments including disphosphonates and core decompression are used to delay the progression. Lack of satisfactory conservative measures suggests the need for additional research of osteonecrosis including large patient registries to further understand this condition.

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“…Moreover, a recent genome-wide association study from Japan identified long intergenic non-protein coding RNA 1370 (LINC01370) as a candidate risk gene in Japanese patients who have idiopathic ONFH, and stratified their analysis by risk factors suggested that the 12q24 locus was associated with the disease through drinking capacity. 60 …”

Section: Current Concepts Concerning the Pathogenesis Of Onfhmentioning

confidence: 99%

ARCO Consensus on the Pathogenesis of Non-traumatic Osteonecrosis of the Femoral Head

Cui

Koo

et al. 2021

J Korean Med Sci

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Osteonecrosis of the femoral head (ONFH) is a devastating disease frequently leading to femoral head collapse and hip arthritis. Specifically, non-traumatic ONFH primarily affects young and middle-aged adults. Although compromised local circulation of the femoral head seems to be pathognomonic for the disease, the pathogenesis is perplexing and continues to be an area of scrutiny and research. Comprehension of the pathogenesis is of crucial importance for developing and guiding treatments for the disease. Therefore, we provide an up-to-date consensus on the pathogenesis of non-traumatic ONFH.

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Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head

Cited by 23 publications

References 63 publications

Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition

Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition

Osteonecrosis of the Femoral Head

ARCO Consensus on the Pathogenesis of Non-traumatic Osteonecrosis of the Femoral Head

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