Genome wide association study of cholesterol and poly- and monounsaturated fatty acids, protein, and mineral content of beef from crossbred cattle

Ahlberg, C. M.; Schiermiester, Lauren N.; Howard,; Calkins, Chris R.; Spangler, Matthew L

doi:10.1016/j.meatsci.2014.07.030

Cited by 19 publications

(20 citation statements)

References 26 publications

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“…In recent years, genome-wide association studies (GWAS) have been widely used to study the molecular mechanism underlying important traits in beef and dairy cattle [25–29]. Previous GWAS and genomic predictions have identified candidate markers associated with various fatty acid composition and evaluated the accuracy of genomic prediction for these traits [8, 30–34]. However, many studies were conducted in populations with relatively low density SNP arrays.…”

Section: Introductionmentioning

confidence: 99%

Genome wide association study and genomic prediction for fatty acid composition in Chinese Simmental beef cattle using high density SNP array

et al. 2017

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BackgroundFatty acid composition of muscle is an important trait contributing to meat quality. Recently, genome-wide association study (GWAS) has been extensively used to explore the molecular mechanism underlying important traits in cattle. In this study, we performed GWAS using high density SNP array to analyze the association between SNPs and fatty acids and evaluated the accuracy of genomic prediction for fatty acids in Chinese Simmental cattle.ResultsUsing the BayesB method, we identified 35 and 7 regions in Chinese Simmental cattle that displayed significant associations with individual fatty acids and fatty acid groups, respectively. We further obtained several candidate genes which may be involved in fatty acid biosynthesis including elongation of very long chain fatty acids protein 5 (ELOVL5), fatty acid synthase (FASN), caspase 2 (CASP2) and thyroglobulin (TG). Specifically, we obtained strong evidence of association signals for one SNP located at 51.3 Mb for FASN using Genome-wide Rapid Association Mixed Model and Regression-Genomic Control (GRAMMAR-GC) approaches. Also, region-based association test identified multiple SNPs within FASN and ELOVL5 for C14:0. In addition, our result revealed that the effectiveness of genomic prediction for fatty acid composition using BayesB was slightly superior over GBLUP in Chinese Simmental cattle.ConclusionsWe identified several significantly associated regions and loci which can be considered as potential candidate markers for genomics-assisted breeding programs. Using multiple methods, our results revealed that FASN and ELOVL5 are associated with fatty acids with strong evidence. Our finding also suggested that it is feasible to perform genomic selection for fatty acids in Chinese Simmental cattle.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-017-3847-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Genome wide association study and genomic prediction for fatty acid composition in Chinese Simmental beef cattle using high density SNP array

et al. 2017

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“…Based on percentage of total lipid, heritability estimates for muscle MUFA were lower (0.60) but still high. The variation in MUFA in the cattle population of Ahlberg et al (2014) was considerable: 26.6 to 56.7% in the semitendinosus muscle and 33.2 to 55.0% in the longissimus thoracis muscle. The variation in MUFA was much less in the current study; this limited our ability to detect genetic differences in the resource cattle population.…”

Section: Discussionmentioning

confidence: 96%

“…Japanese Black and Korean Hanwoo share common ancestors (Zembayashi et al, 1995;Smith et al, 2006;Uemoto et al, 2011), and muscle and adipose tissues from these cattle are higher than in typical breed types raised in the United States, even when raised under identical production conditions. Similarly, heritability of total muscle MUFA was high (0.85) in a population of Angus, Simmental, and Piedmontese steers (n = 236) that were homozygous for the normal myostatin genotype, heterozygous for inactive myostatin, or homozygous for inactive myostatin (Ahlberg et al, 2014). Based on percentage of total lipid, heritability estimates for muscle MUFA were lower (0.60) but still high.…”

Section: Discussionmentioning

confidence: 97%

Adiposity, lipogenesis, and fatty acid composition of subcutaneous and intramuscular adipose tissues of Brahman and Angus crossbred cattle1

Campbell

Lunt

Gill

et al. 2016

Journal of Animal Science

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The objective of this study was to demonstrate differences in aspects of adipose tissue cellularity, lipid metabolism, and fatty and cholesterol composition in Angus and Brahman crossbred cattle. We hypothesized that in vitro measures of lipogenesis would be greater in three-fourths Angus progeny than in three-fourths Brahman progeny, especially in intramuscular (i.m.) adipose tissue. Progeny ( = 227) were fed a standard, corn-based diet for approximately 150 d before slaughter. Breed was considered to be the effect of interest and was forced into the model. There were 9 breed groups including all 4 kinds of three-fourths Angus calves: Angus bulls Angus-sired F cows ( = 32), Angus bulls Brahman-sired F cows ( = 20), Brahman-sired F bulls Angus cows ( = 24), and Angus-sired F bulls Angus cows ( = 20). There were all 4 kinds of three-fourths Brahman calves: Brahman bulls Brahman-sired F cows ( = 21), Brahman bulls Angus-sired F cows ( = 43), Brahman-sired F bulls Brahman cows ( = 26), and Angus-sired F bulls Brahman cows ( = 13). Additionally, F calves (one-half Brahman and one-half Angus) were produced only from Brahman-sired F bulls Angus-sired F cows ( = 28). Contrasts were calculated when breed was an important fixed effect, using the random effect family(breed) as the error term. Most contrasts were nonsignificant ( > 0.10). Those that were significant ( < 0.05) included cholesterol concentration of subcutaneous (s.c.) adipose tissue (three-fourths Angus > F, three-fourths Brahman > F, and three-fourths crossbred progeny combined > F), s.c. adipocyte volume (three-fourths Angus > F and three-fourths bloods combined > F), lipogenesis from acetate in s.c. adipose tissue (three-fourths Brahman calves from Brahman dams > three-fourths Brahman calves from F dams), and percentage 18:3-3 in s.c. adipose tissue (three-fourths Brahman calves from Brahman-sired F dams < three-fourths Brahman calves from Angus-sired F dams). Intramuscular adipocyte volume ( < 0.001) was less in three-fourths Brahman cattle than in three-fourths Angus cattle. Additionally, several differences were observed in i.m. adipose tissue that were consistent with this being a less-developed adipose tissue in three-fourths Brahman cattle than in three-fourths Angus cattle.

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“…The visceral adipose tissue surrounds organs and interferes the function of the organ. Varying proportions of fatty acids from the adipose tissue may be related to atherosclerosis, metabolic syndrome, type 2 diabetes mellitus, cardiovascular and other diseases and might exert a direct influence on serum lipids that may differ depending on the adipose tissue region [8][9][10][11][12]. During cancer development, loss of the total adipose tissue occurs in most cancer patients [13].…”

Section: Introductionmentioning

confidence: 99%

SEM (EDX) is an indispensable tool for the characterization of subcutaneous, preperitoneal and visceral adipose tissue of obese patients

Skaudžius¹,

Misevicius²,

Brimienė³

et al. 2018

chemija

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In this work the scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) elemental analysis were used for the characterization of adipose tissue samples taken from volunteer obese patients. The adipose tissue was taken from subcutaneous, preperitoneal and visceral layers of the adipose tissue. The obtained results provided information about the structural composition of adipose tissue layers in the human body, as well as the main microstructural features. It was demonstrated for the first time, to the best of our knowledge, that SEM and EDX are indispensable tools in order to investigate some special morphological features and the elemental composition of different layers of the human adipose tissue, identifying the surface microstructure and its qualitative composition. From the obtained results we concluded that such characterization of the adipose tissue is an essential step for the possible prediction of symptoms of different diseases.

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Genome wide association study of cholesterol and poly- and monounsaturated fatty acids, protein, and mineral content of beef from crossbred cattle

Cited by 19 publications

References 26 publications

Genome wide association study and genomic prediction for fatty acid composition in Chinese Simmental beef cattle using high density SNP array

Genome wide association study and genomic prediction for fatty acid composition in Chinese Simmental beef cattle using high density SNP array

Adiposity, lipogenesis, and fatty acid composition of subcutaneous and intramuscular adipose tissues of Brahman and Angus crossbred cattle1

SEM (EDX) is an indispensable tool for the characterization of subcutaneous, preperitoneal and visceral adipose tissue of obese patients

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