Genome polymorphism of Mycobacterium avium subsp. hominissuis strains

Старкова, Д. А.; Mokrousov, I. V.; Vyazovaya, Anna; Zhuravlev, Viacheslav; Otten, Tatiana; Vishnevskiy, B. I.; Narvskaya, Olga

doi:10.3103/s0891416814040119

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…MAA and MAH have been the most frequently isolated mycobacterial species from tuberculous lesions in slaughtered pigs and cattle [4,[42][43]. Reports on MAH isolates from pigs and humans being closely related [44][45][46][47][48], and the fact that a common source of MAH infection in these two mammalian species is yet to be identifi ed, reinforce the theory generated by the present study that porcine intestinal organs or pork meat can be a potential source of human MAH infection [27].…”

Section: Mac and Infection In Humans And Pigssupporting

confidence: 68%

Mycobacteriosis in Pigs – An Underrated Threat

Polaček

Aleksić-Kovačević

2016

Acta Veterinaria

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Although Mycobacterium avium subspecies are generally not considered food pathogens, the infections caused by these particular nontuberculous mycobacteria (NTM) can represent a serious threat to immunocompromised population. Additionally, infections with a member of Mycobacterium Avium Compex (MAC) can affect the effi ciency of BCG vaccines used for the humans. In infected animals, M. avium may be present in different tissues without apparent clinical symptoms and macroscopic lesions. Veterinary meat inspection would then fail to recognize infected animals and such meat and meat products thereof could enter the human diet. The aim of this paper is also to analyze the current control policy in Europe according to infections of pigs with the members of MAC, and point out the risks for public health. By analyzing a large number of meat samples and other dietary nutrients, different groups of authors have provided evidence to support the hypothesis that M. avium is present in the everyday environment. Therefore, food as a source of infection with mycobacteria should not be ignored. The control of mycobacteria requires a better diagnostic approach, having in mind recent positive cases of M. avium subspecies hominissuis (MAH) in an increasing number of exported pigs from EU countries to Serbia. The introduction of reliable diagnostic methods for MAH could result in decreasing the occurrence of infection in pigs, as well as in humans, having in mind that WHO reported 10 million new cases of tuberculosis-mycobacteriosis in the human population in 2015 with 21% of these cases occurring in immunocompromised individuals and children.

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Section: Mac and Infection In Humans And Pigssupporting

confidence: 68%

Mycobacteriosis in Pigs – An Underrated Threat

Polaček

Aleksić-Kovačević

2016

Acta Veterinaria

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Single Nucleotide Polymorphisms in hsp65 and MACPPE12 Genes of Mycobacterium avium subsp. hominissuis

Старкова

Iwamoto²,

Vyazovaya

et al. 2019

Russ J Genet

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ing clustered by cgMLST analysis resulting in 19 (9.0%) clustered isolates by cgMLST. By clustering analysis with the distance ≤ 12 SNPs, 18 isolates clustered into 7 clusters. With the 1 SNP cutoff , three clusters with a total of seven strains were found and these were similarly clustered also by cgMLST and conventional genotyping analysis. A reliable prediction of drug susceptibility can be obtained with WGS combined with data analysis with software tools. In routine practice, M. tuberculosis isolates can be screened with WGS for mutations associated with drug resistance, and only resistant strains confirmed with the MGIT system. Compared to conventional genotyping methods, WGS analysis is more discriminatory, reducing the risk of false clustering and unnecessary contact tracing. 6.49

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Genome polymorphism of Mycobacterium avium subsp. hominissuis strains

Cited by 2 publications

References 12 publications

Mycobacteriosis in Pigs – An Underrated Threat

Mycobacteriosis in Pigs – An Underrated Threat

Single Nucleotide Polymorphisms in hsp65 and MACPPE12 Genes of Mycobacterium avium subsp. hominissuis

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