Genome Editing for Global Food Security

FindeR: Accelerating FM-Index-Based Exact Pattern Matching in Genomic Sequences through ReRAM Technology

“…Before a search happens, (low, high) is initialized to (0, 8). In Iteration 0, the last symbol C is processed by LFM where (low, high) is updated to (3,5). After three iterations, (low, high) eventually equals (7,8).…”

“…High throughput sequencing technologies (i.e., Illumina [1], PacBio SMRT [2] and Oxford Nanopore [3]) have revolutionized biological sciences, since they can sequence an entire human genome within a single day. The explosion of genomic data has been the cornerstone in enabling the understanding of complex human diseases [4], ensuring global food security [5] and enforcing wildlife conservation [6]. Several government projects [7] around the world have been launched to deploy whole genome sequencing in clinical practice and public health.…”

Profile of genetically modified plants authorized in Mexico

“…Gene editing is powerfull technology to ingeneer traits in plants. This approach is faster than transgenic approaches, does not requiere antibiotic or herbicide selection, and the engineered mutations are similar to natural mutations (Zhang et al 2017;Ma et al 2018;Zhe et al 2018). Thus, it is safe to predict that transgenic plants currenlty going through the approval process will be replaced in the near future by plants developed through gene editing.…”

“…Thus, it is safe to predict that transgenic plants currenlty going through the approval process will be replaced in the near future by plants developed through gene editing. Furthermore, plants that have not been modified by transgenic approaches, such as sugarcane, bananas, plantains, coffe, or cocoa, are being modified by gene editing (Ma et al 2018) and are expected to enter the approval process soon.…”

“…Benefits of using genetically modified plants to grow food or fiber include improvement in yield and reliability of the food supply in conditions that include changing climate and reduction in farmland (Brookes and Barfoot 2016;Sharp and Leshner 2016;Raman 2017;Taheri et al 2017). Mainly trhough gene editing approaches, currently plants are being developed to enhance nutrient utilization and to tolerate drought, high salt content in the soil, and for environmental remediation (Jez et al 2016;Ma et al 2018). Furthermore, technology is being developed to program novel metabolic pathways in plants for their use as chemical feedstock at industrial levels (Fesenko and Edwards 2014;Jez et al 2016;Lomonossoff and D'Aoust 2016;Ma et al 2018), and to engineer disease resistance for pathogen-plant combinations for which natural resistance has not been identified (Romay and Bragard 2017;Ma et al 2018).…”