Genome analysis of antimicrobial resistance, virulence, and plasmid presence in Turkish Salmonella serovar Infantis isolates

Acar, Sinem; Bulut, Ece; Stasiewicz, Matthew J.; Soyer, Yeşim

doi:10.1016/j.ijfoodmicro.2019.108275

Cited by 26 publications

(36 citation statements)

References 62 publications

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“…Therefore, the core genomebased suggestion of Hindermann et al (2017) that the Hungarian MDR clone of S. Infantis would be documented in Swiss food and human strains and it would have "spread within and outside Europe" seems to be unsubstantiated. Our present data and those from the literature (Gal-Mor et al, 2010;Franco et al, 2015;Tate et al, 2017;Acar et al, 2019) indicate that some S. Infantis clones may emerge and persist in different geographic areas almost simultaneously, suggesting that vertical dissemination of certain clones within the poultry sector should also be considered.…”

Section: Discussionsupporting

confidence: 66%

“…Our data on antimicrobial resistance confirm the recent global emergence of resistance of S. Infantis. From the presented data cannot be concluded that the spread of a single clone could be responsible for the wide spread of antibiotic resistance, but it is more likely to be due to multiple simultaneously appearing clones with similar resistance patterns (Gal-Mor et al, 2010;Franco et al, 2015;Tate et al, 2017;Acar et al, 2019;Bogomazova et al, 2019).…”

Section: Discussionmentioning

confidence: 85%

“…Accordingly, S. Infantis strains of humans and poultry have been studied worldwide (Shahada et al, 2006(Shahada et al, , 2010Cloeckaert et al, 2007;Nógrády et al, 2007Nógrády et al, , 2008Nógrády et al, , 2012Gal-Mor et al, 2010;Dionisi et al, 2011;Tate et al, 2017) and a growing portion of strains proved to be MDR. So far, only few genomic analyses have been reported on different Salmonella serovars (Zou et al, 2013) and S. Infantis strains (Yokoyama et al, 2014), with special regard to MDR S. Infantis of the respective countries (Franco et al, 2015;Hindermann et al, 2017;Szmolka et al, 2018;Acar et al, 2019). Here we provide a comprehensive analysis about the possible relations between S. Infantis strains from different countries and between S. Infantis and other non-Infantis serovars.…”

Section: Discussionmentioning

confidence: 98%

“…Bioinformatic analyses of sequence data from our projects and those available in different databases provided a promising approach to obtain new information and in-depth insights into Salmonella genomics. In case of S. Infantis, the amount of relevant data available in public databases and genomic studies increased significantly in the past few years (Yokoyama et al, 2014;Franco et al, 2015;Hindermann et al, 2017;Acar et al, 2019). However, the type, genome status, and quality of these datasets are usually diverse depending on the intention of the depositors.…”

Section: Introductionmentioning

confidence: 99%

“…So far genomic studies on S. Infantis have primarily dealt with sequences from national collections and studied genomic relations between strains of the respective countries, i.e., Japan, Italy, and Switzerland (Yokoyama et al, 2014;Franco et al, 2015;Hindermann et al, 2017;Acar et al, 2019). In order to understand genomic relations of S. Infantis strains from different geographic origin, here we performed a comprehensive genome analysis of nine Hungarian and further 67 globally selected S. Infantis and 26 other Salmonella strains representing 13 non-Infantis serovars.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Genome Analysis of Hungarian and Global Strains of Salmonella Infantis

et al. 2020

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Introduction: The emergence and spread of new strains of zoonotic bacteria, such as multidrug resistant (MDR) Salmonella Infantis, represent a growing health risk for humans in and outside Europe due to foodborne infections of poultry meat origin. Objectives: In order to understand genome relations of S. Infantis strains from Hungary and from different geographic regions, we performed a comprehensive genome analysis of nine Hungarian and 67 globally selected strains of S. Infantis and 26 Salmonella strains representing 13 non-Infantis serovars. Results: Analyses of whole-, and accessory genomes, showed that almost all S. Infantis strains were separated from the non-Infantis serovars. S. Infantis strains from Hungary formed subclusters based on their time of isolation. In whole genome sequence analysis, the Swiss strains of S. Infantis were closely related to each other and clustered together with subclusters of strains from Hungary, Japan, Italy, United States, and Israel. The accessory genome analysis revealed that the Swiss strains were distinct from most of the strains investigated, including the Hungarian ones. Analysis of the cloud genes offered the most detailed insight into the genetic distance and relationship of S. Infantis strains confirming that the Swiss and Hungarian strains belonged to different lineages. As expected, core genome analysis provided the least discriminatory power for analysis of S. Infantis. Genomic sequences of nine strains from Brazil, Israel, Mexico, Nigeria, and Senegal (deposited as S. Infantis) proved to be outliers from the S. Infantis clade. They were predicted to be Salmonella Rissen, Salmonella Ouakarm, Salmonella Kentucky, Salmonella Thompson, and Salmonella enterica subsp. diarizonae. Conclusion: Accessory genome of S. Infantis showed the highest diversity suggesting a faster evolution than that of the whole genomes contributing to the emergence of multiple genetic variants of S. Infantis worldwide. Accordingly, in spite of the comprehensive analysis of several genomic characteristics, no epidemiologic links between these S. Infantis strains from different countries could be established. It is also concluded that several strains originally designated as S. Infantis need in databanks reclassification.

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