Genital Warts (Anogenital warts)

Abstract

Anogenital warts (AGWs) are the most prevalent sexually transmitted viral infections in the United States of America. Symptomatic warts can be seen in nearly 1% of the population aged 15 to 49 years. Genital warts are highly contagious through sexual contact. AGWs can be diagnosed by careful visual inspection. Several methods have been described for the treatment of warts; however, all have their own limitations and are not always successful. Warts often recur even after being completely removed. The treatments of warts can be divided into two broad categories, ie, surgical and nonsurgical methods. The patient himself/herself can apply the nonsurgical methods, or a physician can perform it. Podophyllotoxin is a good medical substance. Imiquimod can act as an immune response modifier and stimulate locally produced cytokine. Topical treatments of warts increase local production of interferon and decrease viral load of human papiloma virus (HPV). The surgical methods for genital warts include curettage, electrosurgery, and application of a scalpel under general or local anesthesia. Scattered keratinized lesions can be removed by electrosurgery. Patients with multiple or large warts of any location should be referred for surgical treatment under general anesthesia.

Oral Cimetidine as an Adjuvant Therapy for Condyloma Acuminata

“…There was an apparent complete intra-and perioral warts resolution using cimetidine. This is seen in HIVpositive adults that presented with recalcitrant mucosal warts that failed to respond to therapies like curettage and cautery, cryocautery, and oral etretinate [1]. Mitsuishi et al (2003) showed that higher oral dose (30-40 mg/kg/day) was more effective in treating multiple viral warts [17].…”

“…Moreover, no definitive evidence suggests that one treatment is superior to another, and no single therapy is ideal for all patients or warts. Factors that affect response include the presence of immunosuppression and compliance, consisting of either a single or complete treatment course [1,2].…”

“…Although CA is asymptomatic, it presents unique lesion: soft papules, papillomatous nodules, or fibroepithelioma on the external genitalia, anal skin, and perineum. Moreover, the lesions occasionally present bleeding, pruritus (itching), and pain [1,2].…”

A Case of Genital and Extragenital Warts Unresponsive to Immunotherapy Using Measles, Mumps, Rubella Vaccine

“…3 AGWs typically do not cause substantial morbidity or mortality, but the high rate of recurrence might interfere with the patient's quality of life. 12,13 When the HPV infection leads to penile cancer, the condition can be devastating, especially in advanced stages. 3 Various treatment modalities are available, but there is no clear evidence supporting the superiority of any one treatment over another.…”