Genital Infection with Herpes Simplex Virus Types 1 and 2 in Women from Natal, Brazil

Miranda, Cleine Aglacy Nunes; Lima, Érika Galvão; Lima, Diego Breno Soares de; Cobucci, Ricardo Ney; Cornetta, Maria da Conceição de Mesquita; Fernandes, Thales Allyrio Araújo de Medeiros; Azevedo, Paulo Roberto Medeiros de; Azevedo, Jenner Chrystian Veríssimo de; Araújo, Josélio Maria Galvão de; Fernandes, José Veríssimo

doi:10.1155/2014/323657

Cited by 11 publications

(9 citation statements)

References 25 publications

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“…HHV-2 seroprevalence found (20.6%) was greater than that of anti-HHV-2 in pregnant women in Northeast India (8.7 %) (Biswas et al 2011), which is compared to pregnant women from the Northwestern Region of Brazil (12.3%) (Miranda et al, 2014) and to the global prevalence of women (14.8%) (Looker et al, 2015). In this research, pregnant women under 30 years old showed 3.8 times less chance to be exposed to HHV-2 compared to those above 30 years old (ODDS: 3.8;…”

Section: Genital Herpes Is a Sexually Transmitted Infection (Ist)mentioning

confidence: 67%

Seroprevalence of Human Herpesvirus Type 2 in a Reference Center for Pregnant Women in Rio de Janeiro, Brazil

Lima¹,

Padalecki²,

Castro³

et al. 2017

VR&R

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Introduction: Pregnant women stand as an relevant group for research about Human Herpesvirus (HHV-2) infection owing to the risk of mother-to-child transmission. Methods: Women attending in a prenatal care center were tested for HHV-2 IgM and IgG by ELISA. Quantitative PCR test was the chosen method to ascertain viremia. Results: The seroprevalence of IgG and IgM anti-HHV-2 was 20.6% and 2.2% respectively. HHV-2 viremia was found in one pregnant woman with HHV-2 IgM, leading to the assumption of primary infection. Conclusion: The significantly high prevalence of HHV-2 found and the ascertainment of primary infection in a pregnant woman underline the need for constant HHV-2 follow--up and diagnosis in order to avoid sexual transmission.

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Section: Genital Herpes Is a Sexually Transmitted Infection (Ist)mentioning

confidence: 67%

Seroprevalence of Human Herpesvirus Type 2 in a Reference Center for Pregnant Women in Rio de Janeiro, Brazil

Lima¹,

Padalecki²,

Castro³

et al. 2017

VR&R

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“…In HSV-2-induced infection, TAM receptor expression may favor cell susceptibility to ZIKV (entry) as well as permissivity resulting from inflammation ( Figure 4 : Tropism benefit) [ 98 ]. Interestingly, Brazil’s northern region, which has a high number of ZIKV-related microcephaly cases, is also an area with strong seroprevalence for HSV-1 and HSV-2 ( Figure 4 : Epidemiology influence) [ 50 , 149 , 151 , 153 ].…”

Section: Human Latent Virus (Hlv) Selection With Common Interests In Czsmentioning

confidence: 99%

Is the ZIKV Congenital Syndrome and Microcephaly Due to Syndemism with Latent Virus Coinfection?

Grayo

2021

Viruses

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The emergence of the Zika virus (ZIKV) mirrors its evolutionary nature and, thus, its ability to grow in diversity or complexity (i.e., related to genome, host response, environment changes, tropism, and pathogenicity), leading to it recently joining the circle of closed congenital pathogens. The causal relation of ZIKV to microcephaly is still a much-debated issue. The identification of outbreak foci being in certain endemic urban areas characterized by a high-density population emphasizes that mixed infections might spearhead the recent appearance of a wide range of diseases that were initially attributed to ZIKV. Globally, such coinfections may have both positive and negative effects on viral replication, tropism, host response, and the viral genome. In other words, the possibility of coinfection may necessitate revisiting what is considered to be known regarding the pathogenesis and epidemiology of ZIKV diseases. ZIKV viral coinfections are already being reported with other arboviruses (e.g., chikungunya virus (CHIKV) and dengue virus (DENV)) as well as congenital pathogens (e.g., human immunodeficiency virus (HIV) and cytomegalovirus (HCMV)). However, descriptions of human latent viruses and their impacts on ZIKV disease outcomes in hosts are currently lacking. This review proposes to select some interesting human latent viruses (i.e., herpes simplex virus 2 (HSV-2), Epstein–Barr virus (EBV), human herpesvirus 6 (HHV-6), human parvovirus B19 (B19V), and human papillomavirus (HPV)), whose virological features and co-exposition with ZIKV may provide evidence of the syndemism process, shedding some light on the emergence of the ZIKV-induced global congenital syndrome in South America.

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“…Herpes simplex virus (HSV) is a neurotropic virus that possesses a large linear, double-stranded DNA genome, which is presented in the form of two distinct serotypes: HSV-1 and HSV-2 (116). HSV often infects the mucosa of the mouth, eyes and the human anogenital tract (117).…”

Section: Oncolytic Virotherapymentioning

confidence: 99%

Strategies and developments of immunotherapies in osteosarcoma

et al. 2015

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Abstract. Osteosarcoma (OS) is a frequently observed primary malignant tumor. Current therapy for osteosarcoma consists of comprehensive treatment. The long-term survival rate of patients exhibiting nonmetastatic OS varies between 65-70%. However, a number of OS cases have been observed to be resistant to currently used therapies, leading to disease recurrence and lung metastases, which are the primary reasons leading to patient mortality. In the present review, a number of pieces of evidence provide support for the potential uses of immunotherapy, including immunomodulation and vaccine therapy, for the eradication of tumors via upregulation of the immune response. Adoptive T-cell therapy and oncolytic virotherapy have been used to treat OS and resulted in objective responses. Immunologic checkpoint blockade and targeted therapy are also potentially promising therapeutic tools. Immunotherapy demonstrates significant promise with regard to improving the outcomes for patients exhibiting OS.

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Genital Infection with Herpes Simplex Virus Types 1 and 2 in Women from Natal, Brazil

Cited by 11 publications

References 25 publications

Seroprevalence of Human Herpesvirus Type 2 in a Reference Center for Pregnant Women in Rio de Janeiro, Brazil

Seroprevalence of Human Herpesvirus Type 2 in a Reference Center for Pregnant Women in Rio de Janeiro, Brazil

Is the ZIKV Congenital Syndrome and Microcephaly Due to Syndemism with Latent Virus Coinfection?

Strategies and developments of immunotherapies in osteosarcoma

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