Genital Human Papillomavirus Infection among Male and Female Sex Partners: Prevalence and Type-Specific Concordance

Baken, Leslie; Koutsky, Laura A.; Kuypers, Jane; Kosorok, Michael R.; Lee, Shu Kuang; Kiviat, Nancy B.; Holmes, King K.

doi:10.1093/infdis/171.2.429

Cited by 84 publications

(48 citation statements)

References 3 publications

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“…A relatively poor correlation in HPV-positivity has also been reported in previous studies of women and their male sexual partners (Hippelaïnen et al, 1993c; Kyo et al, 1994;Baken et al, 1995;Strand et al, 1995;Castellsagué et al, 1997). The low agreement in our study may be partly due to technical reasons, since a relatively small amount of penile exfoliated cells could be obtained and fewer HPV types could be specifically identified in husbands than wives.…”

Section: Discussionsupporting

confidence: 45%

Prevalence and determinants of human papillomavirus genital infection in men

et al. 2002

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Four-hundred-forty-five husbands of women with invasive cervical carcinoma, 165 of women with in situ cervical cancer, and 717 of control women (age range 19 -82 years) were interviewed and a sample of exfoliated cells from the penis obtained in seven case -control studies conducted by the International Agency for Research on Cancer. The characteristics of human papillomavirus-positive and human papillomavirus-negative husbands were compared using odds ratios and 95% confidence intervals. Thirteen per cent of the husbands of control women, 18% of the husbands of women with invasive cervical carcinoma, and 21% of the husbands of in situ cervical carcinoma women were positive for penile human papillomavirus DNA. Human papillomavirus 16 was detected in 45 husbands, human papillomavirus 18, 31 or 33 in 19, and human papillomavirus 6/11 in 6, but the majority of human papillomavirus infection (158) was with other or unspecified human papillomavirus types. The same human papillomavirus type was seldom identified in both husband and wife. The strongest variation in penile human papillomavirus infection was by country, with percentages among the husbands of control women ranging between 3% in Spain and 39% in Brazil. Having had over 50 lifetime sexual partners, compared with only one, was associated with an odds ratio of 2.3. British Journal of Cancer (2002) The importance of the 'male factor' (Skegg et al, 1982) in the aetiology of cervical carcinoma (CC) in women was suggested years before the identification of a sexually-transmitted virus, human papillomavirus (HPV), as the central cause of these tumours (Dürst et al, 1983;Muñoz et al, 1992). A close correlation has been reported between the frequency of cervical and penile carcinoma in populations (Bosch and Cardis, 1990) and in individual couples (Smith et al, 1980). The development of increasingly accurate assays for HPV detection has brought a clearer understanding of the prevalence of, and risk factors for, cervical HPV infection in women. Human papillomavirus DNA has been identified in 99% of CC specimens (Walboomers et al, 1999). Among women with a normal Pap smear, between a few per cent and more than 50% of women with a normal Pap smear harbour HPV DNA in their cervix, depending upon age and country (Herrero et al, 2000a;Woodman et al, 2001). Conversely, progress in understanding the prevalence and natural history of genital HPV infection in men has been limited. Most surveys of penile HPV infection so far have included a few hundred men at most and have generally been restricted to young individuals (Hippeläinen et al, 1993a,b,c;Baldwin et al, 2001;Kjaer et al, 2001;Lazcano-Ponce et al, 2001).The present study examines the prevalence and determinants of penile HPV infection, according to PCR-based assays, among 1143 husbands of women enrolled in seven case -control studies coordinated by the International Agency for Research on Cancer (IARC). MATERIALS AND METHODSThe combined data included in these analyses were collected in five case-control studies of i...

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Section: Discussionsupporting

confidence: 45%

Prevalence and determinants of human papillomavirus genital infection in men

et al. 2002

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“…A limited number of cross-sectional and case-control studies have evaluated genotype-specifi c HPV concordance in male-female couples (3)(4)(5)(6)(7). There are, however, no empirical data on the heterosexual transmission of HPV.…”

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Transmission of Human Papillomavirus in Heterosexual Couples

Hernandez

Wilkens

Zhu

et al. 2008

Emerg. Infect. Dis.

167

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We examined the transmission of human papillomavirus (HPV) in 25 heterosexual, monogamous couples (25 men, 25 women), followed up over an average of 7.5 months. A total of 53 heterosexual transmission events were observed among 16 couples (14 male-to-female and 39 female-tomale). Sexual transmission involved 13 different oncogenic and nononcogenic HPV types; 8% were vaccine-covered types transmitted between partners. The overall rate of HPV transmission from the penis to the cervix was 4.9/100 person-months, which was substantially lower than that from the cervix to the penis (17.4/100 person-months). Transmission between the hands and genitals, as well as apparent self-inoculation events (primarily in men), were also observed. Couples who transmitted HPV were more sexually active and used condoms less frequently. These results have implications for HPV prevention and control strategies, including the targeting of prophylactic vaccines. C ervical cancer remains a major source of illness and death among women globally, and infection with oncogenic human papillomaviruses (HPVs) is its principal cause (1,2). Men are assumed to be the main reservoirs of genital HPV infection for women, although comparatively little is known about the natural history of HPV in men.A limited number of cross-sectional and case-control studies have evaluated genotype-specifi c HPV concordance in male-female couples (3-7). There are, however, no empirical data on the heterosexual transmission of HPV. Our investigation evaluates the transmission of HPV in a cohort of male-female sexual partners. Methods Study ParticipantsThe study was conducted at the University Health Services of the University of Hawaii at Manoa from CME ACTIVITYMedscape, LLC is pleased to provide online continuing medical education (CME) for this journal article, allowing clinicians the opportunity to earn CME credit. Medscape, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide CME for physicians. Medscape, LLC designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity. All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test and/or complete the evaluation at http://www.medscape.com/cme/eid; (4) view/print certifi cate. Learning ObjectivesUpon completion of this activity, participants will be able to:Identify the most common baseline human papillomavirus ( CME Author

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“…2 HPV infection in men causes genital warts, 3 and is associated with HPV infection 4,5 and cervical cancer 6,7 in female partners.…”

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confidence: 99%

Prevalence and determinants of human papillomavirus infection in men attending vasectomy clinics in Mexico

Vaccarella

Lazcano‐Ponce

Castro-Garduño

et al. 2006

Intl Journal of Cancer

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Large studies of genital human papillomavirus (HPV) infection in men are few and mainly include high-risk groups. We interviewed 779 men who requested a vasectomy in 27 public clinics in 14 states of Mexico. Exfoliated cells were obtained from the scrotum, the shaft of the penis, the top of the penis including the coronal sulcus, the glans and the opening of the meatus. HPV testing was performed using biotinylated L1 consensus primers and reverse line blot. Unconditional logistic regression was used to estimate odds ratios (ORs) of being HPV-positive and corresponding 95% confidence intervals (CIs). The prevalence of any type of HPV was 8.7%. HPV positivity was highest among men below age 25 (13.6%), and lowest among men aged 40 years or older (6.0%). The most commonly found HPV types were, in decreasing order, HPV59, 51, 6, 16 and 58. Lifetime number of sexual partners was associated with HPV positivity (OR for 4 vs. 1 partner 5 3.7, 95% CI: 2.0-6.8), mainly on account of the strong association with number of occasional and sex-worker partners. Condom use with both regular (OR 5 0.4, 95% CI: 0.1-1.0) and sex-worker (OR 5 0.1, 95% CI: 0.0-0.3) partners and circumcision (OR 5 0.2, 95% CI: 0.1-0.4) were inversely associated with HPV positivity. HPV prevalence in Mexican men was similar to the prevalence found in Mexican women of the same age groups. The association between HPV positivity and lifetime number of sexual partners in the present low-risk male population is one of the strongest ever reported in studies in men. Condom use and circumcision were associated with a strong reduction in HPV prevalence. ' 2006 Wiley-Liss, Inc.Key words: human papillomavirus; men; Mexico; sexual habits; condom use Human papillomavirus (HPV) infection, the necessary cause of invasive cervical cancer and its precursor lesions, 1 is a very common sexually transmitted disease in women in many populations. 2 HPV infection in men causes genital warts, 3 and is associated with HPV infection 4,5 and cervical cancer 6,7 in female partners.Previous studies on genital HPV infection in men showed an approximately equal prevalence of HPV infection in any population in the 2 genders, 8 and the existence of a direct, though moderate, association between HPV positivity among men and lifetime number of sexual partners. 9,10 However, contrary to the relatively large amount of information on genital HPV infection in women, 2,11 large studies on HPV prevalence in the general male population are few. Furthermore, the majority of studies in men have focused on young individuals 12 or high-risk populations [e.g., men attending sexually transmitted disease (STD) clinics 9,13,14 or enrolled in military service [15][16][17] ].Two previous reports from Mexico 12,17 showed that more than one-third of the young men studied were infected with genital HPV. To further elucidate the characteristics of HPV infection in the general male population, we assessed the prevalence and determinants of infection with 35 HPV types among 779 Mexican men who attended publi...

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Genital Human Papillomavirus Infection among Male and Female Sex Partners: Prevalence and Type-Specific Concordance

Cited by 84 publications

References 3 publications

Prevalence and determinants of human papillomavirus genital infection in men

Prevalence and determinants of human papillomavirus genital infection in men

Transmission of Human Papillomavirus in Heterosexual Couples

Prevalence and determinants of human papillomavirus infection in men attending vasectomy clinics in Mexico

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