Genital group B streptococcus carrier rate and serotype distribution in Korean pregnant women: implications for group B streptococcal disease in Korean neonates

Hong, Joon Seok; Choi, Chang Won; Park, Kyoung Un; Kim, Shi Nae; Lee, Hyun Ju; Lee, Hye Ryun; Choi, Eun Hwa; Park, Kyo Hoon; Suh, Chang Suk; Kim, Beyong Il; Choi, Seok Tae; Kim, Sung Su

doi:10.1515/jpm.2010.050

Cited by 27 publications

(19 citation statements)

References 18 publications

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“…The ST-17 to GBS ratio was 18.72%. The prevalence rate of GBS colonization was similar to that of our neighboring countries, such as Korea (8–10%) and Hong Kong (10.4%) [14,15,16]. The genital ST-17 carrier rate in pregnant women had never been published before.…”

Section: Discussionsupporting

confidence: 67%

Epidemiology of Group B Streptococcus ST-17 Clone in Pregnant Women of South Taiwan

Hsu

Shen³

et al. 2012

Gynecol Obstet Invest

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Objectives: We aimed to utilize a simple molecular assay to simultaneously detect both group B Streptococcus (GBS) and virulent ST-17 rectovaginal colonization. We also attempted to estimate the prevalence of maternal GBS and ST-17 carriers and to evaluate their seasonal association. Subjects and Methods: We used an optimized multiplex PCR method employing scp-B and ST-17 primers to analyze DNA extracted from rectovaginal swabs of 3,064 cases collected over 3 years. The incidence trends, seasonal variations, and temperature preference were analyzed. Results: The overall prevalence of maternal colonization for GBS and ST-17 clone were 13.25 and 2.48%, respectively. The ST-17 to GBS ratio was 18.72%. The occurrence of ST-17 colonization was significantly associated with seasonal variations with a preference for lower temperatures. Conclusions: We developed a novel multiplex PCR method suitable for the simultaneous detection of GBS and ST-17 clone. The phenomenon of lower temperature preference for ST-17 clone necessitates further investigation. The epidemiological data for GBS and ST-17 incidence are especially important to establish a public policy for universal GBS screening in the future.

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Section: Discussionsupporting

confidence: 67%

Epidemiology of Group B Streptococcus ST-17 Clone in Pregnant Women of South Taiwan

Hsu

Shen³

et al. 2012

Gynecol Obstet Invest

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“…Among pregnant women, the rate of GBS carriage in the vaginal and rectal microbiota is similar in both developing and developed countries (181920), although large variations in the colonization rates are observed in different populations (21). In Korea, the reported carriage rates are 6.3%–11.5% among pregnant women (222324). However, the titers of pathogen-specific antibodies in IVIG may varying according to the plasma source, as they are influenced by the cumulative environmental exposure of the donor population.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a conjugate vaccine incorporating the 5 GBS serotypes (Ia, Ib, II, III, and V) could prevent > 85% of GBS disease among < 3-month-old infants throughout the world (31). In Korea, the most prevalent serotypes are III, V, and Ia (in that order) (222324), and different populations exhibit varying serotype distributions (3031). Therefore, further studies are needed to consider the other serotypes (II and V) in their analyses.…”

Section: Discussionmentioning

confidence: 99%

Opsonophagocytic Antibodies to Serotype Ia, Ib, and III Group BStreptococcusamong Korean Infants and in Intravenous Immunoglobulin Products

et al. 2017

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Group B streptococcus (GBS) infection is a leading cause of sepsis and meningitis among infants, and is associated with high rates of morbidity and mortality in many countries. Protection against GBS typically involves antibody-mediated opsonization by phagocytes and complement components. The present study evaluated serotype-specific functional antibodies to GBS among Korean infants and in intravenous immunoglobulin (IVIG) products. An opsonophagocytic killing assay (OPA) was used to calculate the opsonization indices (OIs) of functional antibodies to serotypes Ia, Ib, and III in 19 IVIG products from 5 international manufacturers and among 98 Korean infants (age: 0–11 months). The GBS Ia, Ib, and III serotypes were selected because they are included in a trivalent GBS vaccine formulation that is being developed. The OI values for the IVIG products were 635–5,706 (serotype Ia), 488–1,421 (serotype Ib), and 962–3,315 (serotype III), and none of the IVIG lots exhibited undetectable OI values (< 4). The geometric mean OI values were similar for all 3 serotypes when we compared the Korean manufacturers. The seropositive rate among infants was significantly lower for serotype Ia (18.4%), compared to serotype Ib and serotype III (both, 38.8%). Infant age of ≥ 3 months was positively correlated with the seropositive rates for each serotype. Therefore, only a limited proportion of infants exhibited protective immunity against serotype Ia, Ib, and III GBS infections. IVIG products that exhibit high antibody titers may be a useful therapeutic or preventive measure for infants. Further studies are needed to evaluate additional serotypes and age groups.

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“…Previously reported GBS positive rates among pregnant Korean women were 4.8% by enrichment culture using a cotton swab, and 6.2% by enrichment PCR using a cotton swab . Hong et al . reported GBS positive rates of 4.0% and 10% for vaginal specimens and vaginal and/or anorectal specimens, respectively.…”

Section: Discussionmentioning

confidence: 98%

“…In Korea, the genital GBS carrier rate was 2.3% in 1998, which was considerably lower than rates reported in the West . However, maternal GBS carrier rate seem to have increased recently in Korea, and relatively few studies have been performed on the topic …”

Section: Introductionmentioning

confidence: 90%

Detection and genomic analysis of genital group B streptococcus in pregnant Korean women

Lee

Kim

Park

et al. 2018

J of Obstet and Gynaecol

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Genital group B streptococcus carrier rate and serotype distribution in Korean pregnant women: implications for group B streptococcal disease in Korean neonates

Abstract: Increased maternal genital GBS carrier rate and difference in serotype distribution pattern of GBS may be related to the recent increase of late-onset GBS disease in Korea.

Cited by 27 publications

References 18 publications

Epidemiology of Group B <b><i>Streptococcus</i></b> ST-17 Clone in Pregnant Women of South Taiwan

Epidemiology of Group B <b><i>Streptococcus</i></b> ST-17 Clone in Pregnant Women of South Taiwan

Opsonophagocytic Antibodies to Serotype Ia, Ib, and III Group BStreptococcusamong Korean Infants and in Intravenous Immunoglobulin Products

Detection and genomic analysis of genital group B streptococcus in pregnant Korean women

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