Genital cytology in obstetric and gynecologic patients. A four-year study

Cuyler, W. Kenneth; Kaufmann, Louise A.; Carter, Bayard; Ross, Robert A.; Thomas, Walter L.; Palumbo, Leonard

doi:10.1016/0002-9378(51)90518-2

Cited by 32 publications

(3 citation statements)

References 5 publications

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“…It is probable that its enforcement would involve the rejection of a significant proportion of the type of material at present being used for cytodiagnosis. But this seems unavoidable in view of the significant proportion of false negative results arising from present techniques of collection and preparation (Graham and Meigs, 1949;Cuyler, Kaufmann, Carter, Ross, Thomas, and Palumbo, 1951;Friedell, Hertig, and Younge, 1960;Richart, 1964;Fidler, Boyes, and Worth, 1968;Evans and Sanerkin, 1970;Yule, 1973).…”

Section: Discussionmentioning

confidence: 99%

Observer variation and quality control of cytodiagnosis

et al. 1974

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SYNOPSISThe aim of quality control of a laboratory investigation is to ensure that similar results are obtained on the same material at different centres. To investigate its practicability in cytodiagnosis, the same cytological material was examined independently at six centres. Each centre supplied material from 20 cases, providing a total of 120 cases, ie, 100 cases excluding the donor centre's own material. The degree of agreement between the centres was studied using (a) the standard National Health Service cytology report terminology, (b) the centre's own terminology, and (c) the recommended recall time. The results revealed close agreement between five out of six centres in the reports obtained in relation to dysplasia and malignancy, namely, less than 3 % false negative results and not more than 1-7 % false positive results. The recommended recall time provided a similar order of agreement after discrepancies due to the management of inflammatory conditions had been eliminated. There was marked disagreement in the diagnosis of both presence and type of infection. The results indicate that improvement in the quality of cytological material would increase the consistency of cytodiagnosis. Cytodiagnosis itself, being an expression of opinion, does not appear to be an appropriate field for quality control.The aim of quality control of a laboratory investigation is to ensure that similar results are obtained on the same material at different centres. To investigate its practicability in cytodiagnosis the same cytological material was examined independently at six centres. The present investigation differs from a previous study in this field (Evans and Sanerkin, 1970) in that the material studied was provided in equal proportion by each of the centres concerned instead of being supplied by only one centre. This was in order to diminishbiasarising out of the nature of the material, eg, due to staining characteristics which might be more acceptable to one centre than to others. Materials and MethodsThe six centres participating in the study were 945Each centre provided 20 slides and was requested to select the material from the routine intake to the cytology department, removing from this a sufficient number of normal slides to provide a relatively high proportion of abnormal slides. The material supplied was from cervical scrapes with the exception of that from centre D where approximately half the slides were from vaginal aspirates. Every centre was asked to examine the slides in essentially the same way that they would adopt when examining the material from their own clinics. Accompanying each slide was the usual clinical information provided on the National Health Service (NHS) cytology form and the report was made using the NHS coding. In addition each centre gave a written report using its own terminology and also gave a recommended recall time andareport on the presence and type of inflammation.The centre providing the cytological material was deemed the reference centre for that case and had access to ...

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Section: Discussionmentioning

confidence: 99%

Observer variation and quality control of cytodiagnosis

et al. 1974

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“…(Papanicolaou, 1933(Papanicolaou, , 1946Bonime, 1950;de Allende and Orias, 1950;Cuyler et al, 1951;Goldhar, Grody and Masters, 1952;Pundel, 1952). The vaginal smear was analyzed for evidence of ovarian function, and the result reported, giving the number of cornified cells as a percentage of the total number of epithelial cells, based on a 300-500 cell count whenever possible.…”

Section: Reportingmentioning

confidence: 99%

The Value of the Vaginal Smear in the Treatment of Disorders of Menstruation

Egerton

1957

BJOG

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“…(a) The accuracy of the cervical and vaginal smear.-In the last decade a number of mass investigations of the smear technique have been performed in the North American continent and in some instances (Cuyler et al, 1951;Graham and Meigs, 1949;Nieburgs and Pund, 1950;Skapier, 1949b) tens of thousands of women have been examined. In the majority of such series accuracy of the results by no means varies according to the numbers of patients examined.…”

Section: Mr a J Wrigleymentioning

confidence: 99%

Discussion on the Value of Vaginal Cytology in the Diagnosis of Carcinoma

1956

Proceedings of the Royal Society of Medicine

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IT appears to me that at the present time the value of the cytological examination of the vaginal smear lies firstly in its use in preliminary diagnosis. Experience gained abroad and in this country shows that the cytological method possesses a considerable degree of accuracy in the diagnosis of carcinoma, and especially of the cervix. Graham (1953), working in Voston, stated that cancer cells were found in 423 of 469 cases of squamous-cell carcinoma

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Genital cytology in obstetric and gynecologic patients. A four-year study

Cited by 32 publications

References 5 publications

Observer variation and quality control of cytodiagnosis

Observer variation and quality control of cytodiagnosis

The Value of the Vaginal Smear in the Treatment of Disorders of Menstruation

Discussion on the Value of Vaginal Cytology in the Diagnosis of Carcinoma

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