Genistein Induces Apoptosis of RPE-J Cells by Opening Mitochondrial PTP

Effects of Mirazid® and myrrh volatile oil on adult Fasciola gigantica under laboratory conditions

“…They changed the fluidity of membranes, which became abnormally permeable resulting in leakage of radicals, cytochrome C, calcium ions and proteins, as in the case of oxidative stress and bioenergetic failure. Permeabilization of outer and inner mitochondrial membranes led to cell death by apoptosis and necrosis [27,28] .…”

The Effects of Biological Sex and Diet on the Development of Heart Failure

“…139,140 However, genistein has also been shown to induce apoptosis through additional factors such as caspase-3 activation (an end-effector of apoptosis) and reduction in mitochondrial membrane potential. [141][142][143] These latter actions of genistein would be detrimental to cardiac health. Given these conflicting properties of soy isoflavones, it is difficult to predict which bioactive activity of isoflavones will predominate in the context of CVD in both humans and laboratory rodents.…”

Actividad insecticida del aceite esencial de Lepechinia chamaedryoides (Balb.) Epling en Drosophila melanogaster

“…El aceite esencial de S. acetabulosa posee actividad citotóxica también contra células de adenocarcinoma renal (CI 50 = 6,8 μg/mL). Así, se puede extrapolar la información, postulando que ha habido apoptosis en células normales de discos imaginales y células epiteliales de las glándulas salivales de la "mosca del vinagre", derivadas por el estrés al ser expuestos a la concentración de aceite esencial de L. chamaedryoides, produciendo muerte celular (Yoon et al 2000, Armstrong 2006). Esta información obtenida debe ser confirmada en forma más específica, en donde se incluya el uso de marcadores específicos para apoptosis en larvas tratadas con aceite esencial de L. chamaedryoides.…”