Effects of Mirazid® and myrrh volatile oil on adult Fasciola gigantica under laboratory conditions

Larvicidal activity of camphor and lavender oils against sheep blowfly, Lucilia sericata (Diptera: Calliphoridae)

“…Similar cuticular changes were observed in Chrysomyia albiceps larvae treated with spinosad; a metabolite of actinomycete Saccharopolyspora spinosa, ginger roots of Zingiber officinale and garlic fruits of Allium sativum (Shams El-Din 2010) as well as C. megacephlala treated with volatile oils of Eucalytal eucalyptal (Sukontason et al 2004) and neem extract (Siriwattanarungsee et al 2008). Comparable swelling, blebbing and distortion of the body cover in intestinal and liver parasites were observed following treatment with essential oils of myrrh (Massoud et al 2012), Nigella sativa Shalaby and El-Moghazy 2013) and Allium sativum (Shalaby and Farag 2014).…”

A retrospective survey of liver flukes in livestock based on abattoir data in Kermanshah, west of Iran

“…The liver flukes (Fasciola spp. and Dicrocoelium dendriticum) are recognized as one of the most important ruminant's helminthic parasites which are found in many parts of the world including Iran (Kantzoura et al 2011;Massoud et al 2012).…”

“…Although a review of available literature strongly suggests that fasciolosis exists in almost all parts of the country, but its prevalence among domestic animals is higher in the southern part of the country, whereas the number of reported human disease cases is significantly higher in the Northern provinces (Khanjari et al 2014). The prevalence of human fasciolosis in many parts of Iran is quite high and was reported to be as high as 10,000 cases for some years (Massoud 1993;Abdou 2000). Recently, a minor emergence of fasciolosis, with 17 nonfatal cases, reported in the Kermanshah, western Province of Iran (Hatami et al 2000).…”

Schistosomiasis therapeutics: whats in the pipeline?

“…[21] The newest anti-schistosome drug is Mirazid which targets early stages of the parasite. [22] Developed from myrrh, it is used almost exclusively in Egypt where it is produced by Pharco Pharmaceuticals. Its efficacy against S. mansoni and S. haematobium is still controversial (lack of efficacy shown in experimental studies [23]) and has only recently been mass analyzed.…”

“…In addition its pharmacokinetics in humans and mode of action against trematodes remain unclear. [22] Currently, there are no schistosome drug candidates under human clinical trials. However, there is a lot of research being conducted to identify new drug targets as well as repurpose current drugs as comprehensively reviewed by El Ridi and Tallima.…”