Genistein as an anti-inflammatory agent

Verdrengh, Margareta; Jonsson, I-M; Holmdahl, Rikard; Tarkowski, Andrej

doi:10.1007/s00011-003-1182-8

Cited by 216 publications

(152 citation statements)

References 47 publications

(36 reference statements)

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“…42 Genistein-treated and collagen II immunized mice showed milder inflammation and joint destruction. 43 In vitro, we have shown that, unlike rosiglitazone and PGD2, genistein had both adipogenic and anti-inflammatory properties on synovial fibroblasts. Furthermore, we have shown that genistein downregulated glucocorticoid-induced leptin production and leptin receptor expression in synovial fibroblasts while having additive antiinflammatory properties.…”

Section: Discussionmentioning

confidence: 95%

Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts

Relić

Zeddou

Desoroux

et al. 2009

Laboratory Investigation

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It was shown recently that synovial fibroblast transformation into adipocytes reduced the expression of interleukin-6 (IL-6) and IL-8. However, the synovial fibroblast adipogenesis was inhibited in inflammatory conditions induced by the tumor necrosis factor-a (TNF-a). Furthermore, adipogenesis is often accompanied by leptin production, a proinflammatory adipokine in rheumatic diseases. In this study, we tested the phytohormone genistein for adipogenic and anti-inflammatory properties on human synovial fibroblasts. Results showed that genistein was able to transform synovial fibroblasts into adipocytes that expressed perilipin-A and produced adiponectin, but not leptin. Furthermore, genistein enhanced glucocorticoid-mediated synovial fibroblast adipogenesis and, in parallel, downregulated glucocorticoid-induced leptin and leptin receptor. Endogenous and TNF-a-induced expressions of IL-6, IL-8, p38, p65 and C/EBP-b were also downregulated by genistein, showing its anti-inflammatory properties. Peroxisome proliferatoractivated receptor-g (PPAR-g) agonist, rosiglitazone, had a synergic effect on genistein-induced adipogenesis, whereas the non-active tyrosine kinase inhibitor, daidzein, had a significantly inferior adipogenic activity than genistein. The Janus kinase-2 tyrosine kinase inhibitor, AG 490, mimicked the anti-leptin effect of genistein. These results showed that genistein-induced adipogenesis involves PPAR-g induction and tyrosine kinase inhibition. In conclusion, genistein, alone or coupled with glucocorticoids, have both adipogenic and anti-inflammatory effects on synovial fibroblasts.

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Section: Discussionmentioning

confidence: 95%

Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts

Relić

Zeddou

Desoroux

et al. 2009

Laboratory Investigation

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“…In animal models, genistein induced dose-dependent reduction in thymic weight, reduced the number of peripheral CD4+ and CD8+ cells, suppressed antigen-specific immune response [89] and decreased levels of IFN-γ protein [90]. Due to its unique effect on the immune system, genistein has been used in the treatment of collagen-induced arthritis, an animal model for RA: mice receiving genistein prior to immunization with collagen showed less frequent and less severe arthritis than controls [91]. The in vivo findings have been confirmed by in vitro experiments: genistein inhibited lymphocyte proliferation response induced by mitogen or alloantigen [89].…”

Section: Effects Of Environmental Estrogens On the Immune Systemmentioning

confidence: 99%

The role of environmental estrogens and autoimmunity

Chighizola

Meroni

2012

Autoimmunity Reviews

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“…We had investigated the inflammation rate of the pulp after operation, low concentration group was minor inflammation compared to the control. It has been reported that genistein may reduce inflammation via inhibition of cyclooxygenase activity 38,39) , and inhibition of vascular permeability by suppressing the expression of VEGF and its receptor gene 40,41) , we considered that suppression of inflammation in these same mechanisms. So, we supposed that improvement of covering degree is induced by short-term reducing inflammation.…”

Section: Discussionmentioning

confidence: 99%

The possibility of genistein as a new direct pulp capping agent

et al. 2013

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Genistein, kind of soy isoflavones, is well-known as natural ingredients and consumed as health foods and supplements. They are expected to improve renal function. They have high-affinity to estrogen receptor β expressed predominantly in bone tissue, they prevent osteoporosis specifically and safely. We examined whether genistein can be a new direct capping agent. In this study, we examined the effect of genistein for the proliferation and differentiation of rat dental pulp cells in vitro and the ability of tertiary dentin formation in vivo. As a result, rat dental pulp cells with genistein were increased activity of ALPase and showed alizarin red positive-staining. Calcification-related genes expression has been confirmed by the addition of genistein. From in vivo study, high quality of tertiary dentin formation and minor pulp reaction were observed. From these findings, it was suggested that genistein may be useful agent for direct pulp capping.

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Genistein as an anti-inflammatory agent

Abstract: We conclude that genistein exerts evident anti-inflammatory properties affecting granulocytes, monocytes, and lymphocytes.

Cited by 216 publications

References 47 publications

Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts

Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts

The role of environmental estrogens and autoimmunity

The possibility of genistein as a new direct pulp capping agent

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