The possibility of genistein as a new direct pulp capping agent

Hayashi, Keijiro; Handa, Keisuke; Koike, Toshiyuki; Saito, Takashi

doi:10.4012/dmj.2013-091

Cited by 9 publications

(9 citation statements)

References 42 publications

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“…A protective role of genistein on dental pulp has been observed in vivo ; so, it might prove useful as a capping agent to decrease the inflammation at the site of pulp exposure [132]. In an animal model, genistein had effects on sexual behavior, which was impaired when male rats were exposed to genistein in the neonatal period [133].…”

Section: Update On Chemical Classes Comprising Erα and Erβ Modulatorsmentioning

confidence: 99%

Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential

et al. 2014

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Estrogen receptors alpha (ERα) and beta (ERβ) are nuclear transcription factors that are involved in the regulation of many complex physiological processes in humans. Modulation of these receptors by prospective therapeutic agents is currently being considered for prevention and treatment of a wide variety of pathological conditions, such as, cancer, metabolic and cardiovascular diseases, neurodegeneration, inflammation, and osteoporosis. This review provides an overview and update of compounds that have been recently reported as modulators of ERs, with a particular focus on their potential clinical applications.

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Section: Update On Chemical Classes Comprising Erα and Erβ Modulatorsmentioning

confidence: 99%

Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential

et al. 2014

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“…Direct pulp capping is the only treatment option to promote this regenerative process, but the long-term success rate is reported to be approximately 60%–70% [4,5]. To improve the success rate, many investigations have used growth factors, transcription factors, or other molecules as pulp capping agents [6,7,8]. However, an evidence-based pulp capping material is not available at present because the wound healing mechanism of pulp tissue is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Protein S100-A7 Derived from Digested Dentin Is a Critical Molecule for Dentin Pulp Regeneration

Komichi

Takahashi

Okamoto

et al. 2019

Cells

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Dentin consists of inorganic hard tissue and organic dentin matrix components (DMCs). Various kinds of bioactive molecules are included in DMCs and some of them can be released after digestion by endogenous matrix metalloproteinases (MMPs) in the caries region. Digested DMCs induced by MMP20 have been reported to promote pulpal wound healing processes, but the released critical molecules responsible for this phenomenon are unclear. Here, we identified protein S100-A7 as a critical molecule for pulpal healing in digested DMCs by comprehensive proteomic approaches and following pulp capping experiments in rat molars. In addition, immunohistochemical results indicated the specific distribution of S100-A7 and receptor for advanced glycation end-products (RAGE) as receptor for S100-A7 in the early stage of the pulpal healing process, and following accumulation of CD146-positive stem cells in wounded pulp. Our findings indicate that protein S100-A7 released from dentin by MMP20 might play a key role in dentin pulp regeneration.

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“…Nevertheless, experimental protocols in rat molars vary, particularly with regard to the site of pulpal exposure [ 4 5 6 7 8 9 10 11 12 ]. An approach via the occlusal surface has been reported to be superior to the mesial surface due to the ability to control the size and depth of pulpal exposure [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of the exposure site on histological pulpal responses after direct capping with 2 calcium-silicate based cements in a rat model

et al. 2018

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ObjectivesDirect pulp capping is a treatment for mechanically exposed pulp in which a biocompatible capping material is used to preserve pulpal vitality. Biocompatibility tests in animal studies have used a variety of experimental protocols, particularly with regard to the exposure site. In this study, pulp exposure on the occlusal and mesial surfaces of molar teeth was investigated in a rat model.Materials and MethodsA total of 58 maxillary first molars of Wistar rats were used. Forty molars were mechanically exposed and randomly assigned according to 3 factors: 1) the exposure site (occlusal or mesial), 2) the pulp-capping material (ProRoot White MTA or Bio-MA), and 3) 2 follow-up periods (1 day or 7 days) (n = 5 each). The pulp of 6 intact molars served as negative controls. The pulp of 12 molars was exposed without a capping material (n = 3 per exposure site for each period) and served as positive controls. Inflammatory cell infiltration and reparative dentin formation were histologically evaluated at 1 and 7 days using grading scores.ResultsAt 1 day, localized mild inflammation was detected in most teeth in all experimental groups. At 7 days, continuous/discontinuous calcified bridges were formed at exposure sites with no or few inflammatory cells. No significant differences in pulpal response according to the exposure site or calcium-silicate cement were observed.ConclusionsThe location of the exposure site had no effect on rat pulpal healing. However, mesial exposures could be performed easily, with more consistent results. The pulpal responses were not significantly different between the 2 capping materials.

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The possibility of genistein as a new direct pulp capping agent

Cited by 9 publications

References 42 publications

Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential

Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential

Protein S100-A7 Derived from Digested Dentin Is a Critical Molecule for Dentin Pulp Regeneration

Effects of the exposure site on histological pulpal responses after direct capping with 2 calcium-silicate based cements in a rat model

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