Geniposide augments apoptosis in fibroblast-like synoviocytes by restoring hypoxia-enhanced JNK-BNIP3-mediated autophagy
Deng Ran,
Wang Yan,
Bu Yanhong
et al.
Abstract:As the main effector cells of chronic in ammation and hyperplasia of synovium, broblast-like synoviocytes (FLSs) show abnormal proliferation and insu cient apoptosis in hypoxic microenvironment, which is due to the increase of BNIP3-mediated autophagy. This study aimed to explore the mechanism of geniposide (GE) on hypoxia-induced hyper-proliferative FLSs with a focus on autophagy and JNK-BNIP3 pathway.
Materials and methodsThe dynamic changes of autophagy and apoptosis and the expression of hypoxia related pr… Show more
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