Geniposide activates GSH S-transferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes

Kuo, Wu‐Hsien; Chou, Fen‐Pi; Young, Shun-Chieh; Chang, Yun-Ching; Wang, Chau‐Jong

doi:10.1016/j.taap.2005.02.013

Cited by 47 publications

(29 citation statements)

References 30 publications

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“…Some GSTs have been shown to be upregulated through the MAPK pathways as self-defense responses to toxins and growth factors [54,55]. In reproductive cells, p38 MAPK plays a pivotal role in oocyte maturation [56][57][58] and steroidogenesis [59,60].…”

Section: Discussionmentioning

confidence: 99%

Protein expression in human cumulus cells as an indicator of blastocyst formation and pregnancy success

Braga

Setti

Turco

et al. 2016

J Assist Reprod Genet

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Purpose The goal for the present study was to implement a technique for protein extraction and identification in human cumulus cells (CCs). Methods Forty samples of CCs were collected after ovum pick-up from patients undergoing intracytoplasmic sperm injection (ICSI). Samples were split into the blastocyst group (n = 10), including patients in which all embryos converted into blastocysts, and the non-blastocyst group (n = 10), including patients in which none of the embryos reached the blastocyst stage or the positive-pregnancy (n = 10) and negativepregnancy group (n = 10). Proteins were extracted and injected into a liquid chromatography system coupled to a mass spectrometer. The spectra were processed and used to search a database. Results There were 87 different proteins in samples from the blastocyst and non-blastocyst groups, in which 30 were exclusively expressed in the blastocyst group and 17 in the nonblastocyst group. Among the 72 proteins detected in the pregnancy groups, 19 were exclusively expressed in the positive, and 16 were exclusively expressed in the negative-pregnancy group. Conclusions CC proteomics may be useful for predicting pregnancy success and the identification of patients that should be included in extended embryo culture programs.

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Section: Discussionmentioning

confidence: 99%

Protein expression in human cumulus cells as an indicator of blastocyst formation and pregnancy success

Braga

Setti

Turco

et al. 2016

J Assist Reprod Genet

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“…[9][10][11] It was reported that geniposide activated reduced glutathione (GSH) S-transferase by the induction of glutathione S-transferase (GST) M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes. 5) In our previous papers, we reported that geniposide induced the neuronal differentiation of PC12 cells and protected PC12 cells from oxidative damage. 6,12) Lee reported that geniposide attenuated neuronal cell death in oxygen and glucose deprivation-exposed rat hippocampal slice cultures.…”

Section: Discussionmentioning

confidence: 91%

“…3,4) Geniposide, an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis, is a popular Chinese herb used to treat febrile diseases including edema, hepatic disorders, acute conjunctivitis, and hematuria. 5) In our previous work, we found that geniposide activates the glucagon-like peptide 1 receptor (GLP-1R) to induce the neuronal differentiation of PC12 cells via the mitogenactivated protein kinase (MAPK) signaling pathway and prevents PC12 cells from oxidative damage induced by H 2 O 2 via the phosphatidylinositol 3-kinase (PI3K) signaling pathway. 6) In the present study, using the model of peroxynitrite stress induced by 3-morpholinosydnonmine hydrochloride (SIN-1), a peroxynitrite generator, we wanted to explore the neuroprotective mechanism of geniposide in PC12 cells.…”

Section: Introductionmentioning

confidence: 99%

Geniposide Prevents PC12 Cells from Peroxynitrite via the Mitogen-Activated Protein Kinase Signaling Pathway

Yin

Liu

Xiao

et al. 2010

JOURNAL OF HEALTH SCIENCE

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“…Geniposide induced glutathione S-transferase (GST) activity and the expression of GST M1 and M2 acting in primary cultured rat hepatocytes through the expression of MEK-1 signaling proteins and the activation of Ras/Raf/ MEK-1 signaling pathway. GSTs are a family of dimeric enzymes, which is responsible for the metabolism of a broad range of xenobiotics (Kuo et al, 2005).…”

Section: Attenuation Of Mitochondrial Oxidative Stress By Geniposidementioning

confidence: 99%

Neuroprotective effects of geniposide on Alzheimer’s disease pathology

Liu

Hölscher³

et al. 2015

Reviews in the Neurosciences

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AbstractA growing body of evidence has linked two of the most common aged-related diseases: type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). It has led to the notion that drugs developed for the treatment of T2DM may be beneficial in modifying the pathophysiology of AD. As a receptor agonist of glucagon-like peptide-1 (GLP-1R), which is a newer drug class to treat T2DM, geniposide shows clear effects in inhibiting pathological processes underlying AD, such as promoting neurite outgrowth. In the present article, we review the possible molecular mechanisms of geniposide to protect the brain from pathologic damages underlying AD: reducing amyloid plaques, inhibiting τ phosphorylation, preventing memory impairment and loss of synapses, reducing oxidative stress and the chronic inflammatory response, and promoting neurite outgrowth via the GLP-1R signaling pathway. In summary, the Chinese herb geniposide shows great promise as a novel treatment for AD.

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Geniposide activates GSH S-transferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes

Cited by 47 publications

References 30 publications

Protein expression in human cumulus cells as an indicator of blastocyst formation and pregnancy success

Protein expression in human cumulus cells as an indicator of blastocyst formation and pregnancy success

Geniposide Prevents PC12 Cells from Peroxynitrite via the Mitogen-Activated Protein Kinase Signaling Pathway

Neuroprotective effects of geniposide on Alzheimer’s disease pathology

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