Geniposide Prevents PC12 Cells from Peroxynitrite via the Mitogen-Activated Protein Kinase Signaling Pathway

Yin, Fei; Liu, Jianhui; Xiao, He; Kong, Shuzhen

doi:10.1248/jhs.56.195

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…Nowadays, the mainstream prevention strategies for vascular restenosis depend on the prohibition of VSMC proliferation and the realization of early reendothelialization and antithrombosis. Geniposide, the main component of traditional Chinese herbal medicine Gardenia jasminoides Ellis, is just fit for all of those requirements, as it plays an important role in the activities of antiinflammation [ 7 , 8 ], antioxidation [ 9 , 10 ], anticoagulation [ 11 ], antithrombosis [ 12 ], cardiovascular protection and cerebral nerve repair [ 13 , 14 ]. Various studies also inferred that Gardeniae Fructus extract exhibited positive effect on promoting endothelial cells (ECs) proliferation, protecting endothelial function injured by variety of factors, and meanwhile, showed no obvious effect on smooth muscle cells (SMCs) [ 15 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

Studies Based on Preparation, Physical Characteristics, and Cellular Pharmacological Activities of Thin PLGA Film Loaded with Geniposide

Zhang

Líu

Huang

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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In this primary study, thin polylactic-co-glycolic acid (PLGA) film loaded with geniposide was first prepared and demonstrated on both physical and pharmacological aspects for its potential application on drug-eluting vascular stents. Physical parameters of geniposide-loaded thin film, such as crystal structure, molecular spectral characteristics, and release behavior in the whole process were detected. From X-Ray diffraction, the characteristic peak of crystal geniposide disappeared on geniposide-loaded PLGA film (GLPF) after it formed, which meant there was no agglomeration phenomenon, as geniposide was distributed in the form of single molecule. According to scanning electron microscopy (SEM) figure, the GLPF was more flat and uniform with better compactness. It inferred that release behavior of geniposide at the early stage (0~15 d) was in the form of free diffusion. Carrier PLGA began to degrade 15 days later, so the residual geniposide was also dissolved. Cellular pharmacological effects of geniposide on endothelial cells (ECs) and smooth muscle cells (SMCs) were also demonstrated on GLPF. 5% and 10% (w/w) geniposide-loaded PLGA (60 : 40) membrane indicated its significant effect on ECs promotion and SMCs inhibition. All provided feasible evidences for the development of new geniposide-coating vascular stent using PLGA as carrier.

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