Genipin Suppresses Subconjunctival Fibroblast Migration, Proliferation and Myofibroblast Transdifferentiation

Kitano, Ai; Saika, Shizuya; Yamanaka, Osamu; Ikeda, Kazuo; Reinach, Peter S.; Nakajima, Yuji; Okada, Yoshinori; Shirai, Kumi; Ohnishi, Yoshitaka

doi:10.1159/000096231

Cited by 32 publications

(24 citation statements)

References 52 publications

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“…[68] find that the hepatoprotective effect of Solanum nigrum Linn extract on CCl 4 -induced liver fibrosis is achieved through blocking oxidative stress. Xiao Chaihu Tang [76,83,85] whose active components baicalin and baicalein function as a potent fibrosis suppressant via the inhibition of the oxidative stress in hepatocyte and HSC. Handan Ganle [99] is effective in protecting against liver fibrosis by inhibiting lipid peroxidation in hepatocytes and HSC in vivo .…”

Section: Action Mechanisms Of Chinese Medicines In Treating Liver Fibmentioning

confidence: 99%

Chinese medicines as a resource for liver fibrosis treatment

et al. 2009

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Liver fibrosis is a condition of abnormal proliferation of connective tissue due to various types of chronic liver injury often caused by viral infection and chemicals. Effective therapies against liver fibrosis are still limited. In this review, we focus on research on Chinese medicines against liver fibrosis in three categories, namely pure compounds, composite formulae and combination treatment using single compounds with composite formulae or conventional medicines. Action mechanisms of the anti-fibrosis Chinese medicines, clinical application, herbal adverse events and quality control are also reviewed. Evidence indicates that some Chinese medicines are clinically effective on liver fibrosis. Strict quality control such as research to identify and monitor the manufacturing of Chinese medicines enables reliable pharmacological, clinical and in-depth mechanism studies. Further experiments and clinical trials should be carried out on the platforms that conform to international standards.

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Section: Action Mechanisms Of Chinese Medicines In Treating Liver Fibmentioning

confidence: 99%

Chinese medicines as a resource for liver fibrosis treatment

et al. 2009

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“…17 It has also been proposed in trabeculotomy to prevent fibrosis by suppressing the fibrogenic response of subconjunctival fibroblasts. 18 This study measured the biomechanical effects of genipin as a CXL agent in the porcine cornea as well its effect on corneal resistance to bacterial collagenase.…”

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confidence: 99%

Effect of genipin collagen crosslinking on porcine corneas

Ávila¹,

Navia²

2010

Journal of Cataract and Refractive Surgery

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“…In ophthalmology, genipin has been suggested in trabeculotomy to prevent subconjunctival fibrosis by suppressing fibroblasts [28]. Its antimyofibroblast activity was also studied as a way to prevent posterior capsular opacification in cataract surgery [29].…”

Section: Discussionmentioning

confidence: 99%

Optimizing Genipin Concentration for Corneal Collagen Cross-Linking: An ex vivo Study

et al. 2018

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Purpose: Studying genipin variable concentrations, treatment durations, and delivery methods as a substance to increase corneal stiffness by inducing corneal collagen cross-linking (CXL). Materials and Methods: 100 bovine corneas treated with different genipin concentrations (0.1, 0.5, and 1%) and treatment durations (15 min, 40 min, 2 h, and 3 days) through different delivery methods compared to 10 controls treated with riboflavin/UV. Histology examination, enzymatic digestion with collagenase and thermal differential scanning calorimetry were performed on the different samples. Results: Bovine corneas soaked in 0.5% genipin morphologically showed 4.7% CXL in comparison to 5.6% in controls (p < 0.05). Corneas treated with topical 0.5% genipin, by a 140-µL drop applied hourly for 2 h, showed 7% corneal CXL. Corneas treated with topical genipin 0.5% for 30 min, 1 and 2 h showed 54 ± 6, 40 ± 7, and 39 ± 9% enzymatic degradation, respectively, in comparison to controls (74%). Corneas treated with 0.5% genipin for 1, 2, and 8 h showed higher thermal denaturation resistance (Td values of 64.9 ± 0.3, 64.7 ± 0.0 and 67.3 ± 0.9), respectively, in comparison to the control group (64.6 ± 0.5) (p < 0.05). Conclusions: Genipin 0.5%, in a 140-µL drop applied hourly for 2 h, showed better potential to enhance corneal stiffness and stability through inducing CXL.

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Genipin Suppresses Subconjunctival Fibroblast Migration, Proliferation and Myofibroblast Transdifferentiation

Cited by 32 publications

References 52 publications

Chinese medicines as a resource for liver fibrosis treatment

Chinese medicines as a resource for liver fibrosis treatment

Effect of genipin collagen crosslinking on porcine corneas

Optimizing Genipin Concentration for Corneal Collagen Cross-Linking: An ex vivo Study

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