Genipin cross-linked carbon dots for antimicrobial, bioimaging and bacterial discrimination

Chu, Xiaohong; Wu, Fan; Zhang, Ming; Song, Saijie; Zhang, Pan; Wang, Yuli; Zhang, Qicheng; Zhou, Ninglin; Shen, Jian

doi:10.1016/j.colsurfb.2020.110930

Cited by 44 publications

(33 citation statements)

References 57 publications

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“…Carbon dot synthesis can be categorized into (1) top-down or (2) bottom-up methods. The most recent publications display a trend of employing a bottom-up method for antibacterial CD synthesis such as hydrothermal synthesis, microwave synthesis, and thermal decomposition (Jian et al, 2017;Ghosal and Ghosh, 2019;Maruthapandi et al, 2019;Shahshahanipour et al, 2019;Zhao et al, 2019;Chu et al, 2020). Hydrothermal synthesis of CDs is a common method that is both eco-friendly and inexpensive (Ghosal and Ghosh, 2019).…”

Section: Synthesis Methods For Cdsmentioning

confidence: 99%

“…Hydrothermal synthesis of CDs is a common method that is both eco-friendly and inexpensive (Ghosal and Ghosh, 2019). It involves a heating of the reaction mixture at a temperature of 150-250 • C for 40 min to 12 h (Jian et al, 2017;Ghosal and Ghosh, 2019;Maruthapandi et al, 2019;Shahshahanipour et al, 2019;Zhao et al, 2019;Chu et al, 2020). In contrast, a microwave synthesis frequently takes under 5 min using microwaves at 500-800 W to break down the carbon bonds of the organic source (Ghosal and Ghosh, 2019).…”

Section: Synthesis Methods For Cdsmentioning

confidence: 99%

“…Furthermore, the use of precursors from biological origins such as amino acid, citric acid and so on in the synthesis of CDs can impart natural biocompatibility and antibacterial properties (Demirci et al, 2020). Modifications of CDs such as the surface functionalization of polyethyleneimine (PEI), colloidal polydopamine (PDA) and genipin have all led to an enhancement of their inhibitory effect on various strains of bacteria (Maruthapandi et al, 2019;Sahiner et al, 2019;Chu et al, 2020). Recent publications not only show that the potential of antibacterial CDs is being currently realized, but with a greater therapeutic advantage than their precursors and competitors.…”

Section: Antibacterial Cdsmentioning

confidence: 99%

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Carbon Dots Fabrication: Ocular Imaging and Therapeutic Potential

Garner

Vichare

Paulson

et al. 2020

Front. Bioeng. Biotechnol.

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Vision loss is a major complication in common ocular infections and diseases such as bacterial keratitis, age-related macular degeneration (AMD) and diabetic retinopathy (DR). The prevalence of such ophthalmic diseases represents an urgent need to develop safe, effective, and long-term treatments. Current therapies are riddled with drawbacks and limitations which calls for the exploration of alternative drug delivery mechanisms. Toxicity of the inorganic metals and metal oxides used for drug delivery raise safety concerns that are alleviated with the alternate use of, a natural and organic polymer which is both biocompatible and environmentally friendly. Carbon dots (CDs) represent a great potential in novel biomedical applications due to their tunable fluorescence, biocompatibility, and ability to be conjugated with diverse therapeutic materials. There is a growing interest on the exploitation of these properties for drug delivery with enhanced bio-imaging. However, there are limited reports of CD applications for ophthalmic indications. In this review, we focus on the CD potential and the development of translational therapies for ophthalmic diseases. The current review presents better understanding of fabrication of CDs and how it may be useful in delivering anti-bacterial agents, anti-VEGF molecules as well as imaging for ophthalmic applications.

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Section: Synthesis Methods For Cdsmentioning

confidence: 99%

Section: Synthesis Methods For Cdsmentioning

confidence: 99%

Section: Antibacterial Cdsmentioning

confidence: 99%

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Carbon Dots Fabrication: Ocular Imaging and Therapeutic Potential

Garner

Vichare

Paulson

et al. 2020

Front. Bioeng. Biotechnol.

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“…Nitrogen (as well as different heteroatoms such as P, O, and S) has also been incorporated during the CD synthesis using a mixture of different starting materials [ 61 ]. For example, the addition of polyamines [ 16 , 62 ], amino acids [ 63 , 64 , 65 , 66 , 67 ], or biomass such as plant leaves and fungi [ 68 , 69 , 70 , 71 , 72 , 73 , 74 ], food [ 75 , 76 , 77 , 78 , 79 ], and industrial [ 80 ] and waste derivatives [ 81 , 82 ], among others, have been used for the preparation of doped CDs. In this context, two independent comparative studies from the Kang [ 83 ] and Bandosz [ 84 ] research groups highlighted that N- or S-doped CDs exhibit very different antibacterial properties.…”

Section: Cds As Bacteria Targeting and Antibacterial Agentsmentioning

confidence: 99%

Carbon Dots as an Emergent Class of Antimicrobial Agents

2021

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Antimicrobial resistance is a recognized global challenge. Tools for bacterial detection can combat antimicrobial resistance by facilitating evidence-based antibiotic prescribing, thus avoiding their overprescription, which contributes to the spread of resistance. Unfortunately, traditional culture-based identification methods take at least a day, while emerging alternatives are limited by high cost and a requirement for skilled operators. Moreover, photodynamic inactivation of bacteria promoted by photosensitisers could be considered as one of the most promising strategies in the fight against multidrug resistance pathogens. In this context, carbon dots (CDs) have been identified as a promising class of photosensitiser nanomaterials for the specific detection and inactivation of different bacterial species. CDs possess exceptional and tuneable chemical and photoelectric properties that make them excellent candidates for antibacterial theranostic applications, such as great chemical stability, high water solubility, low toxicity and excellent biocompatibility. In this review, we will summarize the most recent advances on the use of CDs as antimicrobial agents, including the most commonly used methodologies for CD and CD/composites syntheses and their antibacterial properties in both in vitro and in vivo models developed in the last 3 years.

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“…To evaluate the biocompatibility of COOH-CDs, a toxicity experiment was carried out [21]. Considering its application in lactoferrin detection, lactobacillus plantarum was selected as the model with viable count survival rate as the toxicity index.…”

Section: Toxicity Experimentsmentioning

confidence: 99%

Carboxyl-Rich Carbon Dots as Highly Selective and Sensitive Fluorescent Sensor for Detection of Fe3+ in Water and Lactoferrin

et al. 2021

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As lactoferrin (LF) plays an essential role in physiological processes, the detection of LF has attracted increasing attention in the field of disease diagnosis. However, most current methods require expensive equipment, laborious pretreatment, and long processing time. In this work, carboxyl-rich carbon dots (COOH-CDs) were facilely prepared through a one-step, low-cost hydrothermal process with tartaric acid as the precursor. The COOH-CDs had abundant carboxyl on the surface and showed strong blue emission. Moreover, COOH-CDs were used as a fluorescent sensor toward Fe3+ and showed high selectivity for Fe3+ with the limit of detection (LoD) of 3.18 nM. Density functional theory (DFT) calculations were performed to reveal the mechanism of excellent performance for Fe3+ detection. Meanwhile, COOH-CDs showed no obvious effect on lactobacillus plantarum growth, which means that COOH-CDs have good biocompatibility. Due to the nontoxicity and excellent detection performance for Fe3+, COOH-CDs were employed as a fluorescent sensor toward LF and showed satisfying performance with an LoD of 0.776 µg/mL, which was better than those of the other methods.

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Genipin cross-linked carbon dots for antimicrobial, bioimaging and bacterial discrimination

Cited by 44 publications

References 57 publications

Carbon Dots Fabrication: Ocular Imaging and Therapeutic Potential

Carbon Dots Fabrication: Ocular Imaging and Therapeutic Potential

Carbon Dots as an Emergent Class of Antimicrobial Agents

Carboxyl-Rich Carbon Dots as Highly Selective and Sensitive Fluorescent Sensor for Detection of Fe3+ in Water and Lactoferrin

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