Genetics of epidermodysplasia verruciformis: Insights into host defense against papillomaviruses

Orth, Gérard

doi:10.1016/j.smim.2006.07.008

Cited by 249 publications

(308 citation statements)

References 122 publications

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“…1 Human papillomavirus type 9 is considered an EV-associated HPV. 9 No people in contact with this cat had skin lesions consistent with EV. Therefore, it appears possible that this cat was infected from a person asymptomatically carrying this papillomavirus.…”

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confidence: 92%

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Feline Cutaneous Viral Papilloma Associated with Human Papillomavirus Type 9

Munday

Hanlon²,

Howe

et al. 2007

Vet Pathol

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Abstract.A 12-year-old domestic Shorthaired cat developed a multinodular exophytic mass on the dorsal surface of the nose. The skin surrounding the mass was nonpigmented, and actinic keratosis had been diagnosed in this area 3 years previously. Histologic examination revealed hyperkeratosis, epidermal hyperplasia, papillomatosis, koilocytosis, and possible intranuclear viral inclusions. Polymerase chain reaction amplified papillomaviral deoxyribonucleic acid from formalin-fixed samples of the lesion. Sequencing of the amplicon revealed 98% similarity to human papillomavirus (HPV) type 9. To the authors' knowledge, this is only the second reported feline cutaneous viral papilloma. In addition, this is the first report of a feline papilloma being associated with an HPV.

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confidence: 92%

“…In humans, EV-associated HPVs asymptomatically infect non-EV people but require immunosuppression to produce disease. 9 Second, of the HPVs, HPV type 9 may be uniquely able to infect cats. Human papillomavirus type 9 appears to be rare within people.…”

mentioning

confidence: 99%

Feline Cutaneous Viral Papilloma Associated with Human Papillomavirus Type 9

Munday

Hanlon²,

Howe

et al. 2007

Vet Pathol

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“…Parmi les PVH cutanés ou muqueux, les PVH du genre β se distinguent par l'absence des gènes E5 et E8 [9]. Ainsi, nos résultats viennent corroborer l'hypothèse récem-ment formulée [2] selon laquelle les PVH β, en particulier le PVH5 oncogène, sont des commensaux défectifs très répandus et asymptomatiques dans la population générale. Seules une mutation dans les gènes EVER1 ou EVER2 ou des conditions physiologiques particulières, comme la régénération de l'épiderme [10], sont capables de permettre leur réplication et de lever la restriction d'hôte observée dans la population générale.…”

Section: Les Pvh B Des Commensaux Défectifsunclassified

“…Cependant, certaines lésions génitales persistantes, notamment du col utérin, induites par des PVH potentiellement oncogènes (essentiellement les PVH16 et 18) peuvent se transformer en cancers invasifs chez un petit nombre de patientes [1]. Il en est de même pour les carcinomes de la peau associés au PVH5 chez des patients atteints d'épidermodys-plasie verruciforme (EV) [2]. Des études épidémiologiques sont en faveur de l'implication de facteurs génétiques de l'hôte dans l'issue des lésions génitales, tels que certains allèles de gènes de classe II du complexe majeur d'histocompatibilité ou le gène TSCOT (thymic stromal cotransporter).…”

unclassified

“…En effet, cette génoderma-tose rare, liée en général à un gène de transmission autosomique récessive, est caractérisée par des lésions ressemblant à des verrues planes ou à des macules, apparaissant dès l'enfance et durant toute la vie [2]. L'EV correspond à une sensibilité anormale à l'infection par un groupe de PVH apparentés appartenant au genre bêta (PVH bêta) dont le PVH5 oncogène.…”

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Les papillomavirus humains cutanés oncogènes sont-ils des commensaux défectifs ?

Łazarczyk

Favre

2008

Med Sci (Paris)

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Epidermodysplasia Verruciformis in Human Immunodeficiency Virus–Infected Patients

Jacobelli

Laude²,

Carlotti³

et al. 2011

Arch Dermatol

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Background: Skin eruptions resembling epidermodysplasia verruciformis (EV) are rarely observed in immunocompromised patients. We focused on the epidemiologic, clinical, virologic, and immunologic features of EV in human immunodeficiency virus (HIV)-positive patients. Observations: We studied 11 HIV-positive patients (6 men and 5 women) with clinical and histological features of EV observed at our department. The median age at HIV diagnosis was 27 years. At the onset of eruption, the median age was 40 years and the median CD4 T-cell count was 170/µL. Clinical presentation included flat warts (n=11), pityriasis versicolor-like macules (n=5), and lichenoid papules (n = 3) on sun-exposed skin. Detection and typing of cutaneous human papillomavirus (HPV) were carried out in 8 cases and always revealed ␤-HPV infection, including oncogenic HPV-5 or 8 (n =6). Mu-cosal HPV-related diseases were present in 7 cases. Histories of skin cancer and lymphoproliferative disorder were recorded in 3 and 4 patients, respectively, including 2 fatal cases. Skin eruption was never improved by highly active antiretroviral therapy (HAART). In 2 cases, EV was associated with an immune reconstitution syndrome. The present series is the largest with a complete characterization. A review of similar cases was carried out. Conclusion: Despite effective HAART, HIV-infected patients with EV require a prolonged and careful follow-up to detect mucosal HPV-related diseases, lymphoproliferative disorders, and skin cancers.

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Genetics of epidermodysplasia verruciformis: Insights into host defense against papillomaviruses

Cited by 249 publications

References 122 publications

Feline Cutaneous Viral Papilloma Associated with Human Papillomavirus Type 9

Feline Cutaneous Viral Papilloma Associated with Human Papillomavirus Type 9

Les papillomavirus humains cutanés oncogènes sont-ils des commensaux défectifs ?

Epidermodysplasia Verruciformis in Human Immunodeficiency Virus–Infected Patients

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