Feline Cutaneous Viral Papilloma Associated with Human Papillomavirus Type 9

Abstract

Abstract.A 12-year-old domestic Shorthaired cat developed a multinodular exophytic mass on the dorsal surface of the nose. The skin surrounding the mass was nonpigmented, and actinic keratosis had been diagnosed in this area 3 years previously. Histologic examination revealed hyperkeratosis, epidermal hyperplasia, papillomatosis, koilocytosis, and possible intranuclear viral inclusions. Polymerase chain reaction amplified papillomaviral deoxyribonucleic acid from formalin-fixed samples of the lesion. Sequencing of the amplicon revealed 98% similarity to human papillomavirus (HPV) type 9. To the authors' knowledge, this is only the second reported feline cutaneous viral papilloma. In addition, this is the first report of a feline papilloma being associated with an HPV.

Pathology and immunohistochemistry of papillomavirus-associated cutaneous lesions in Cape mountain zebra, giraffe, sable antelope and African buffalo in South Africa

“…Serum leakage to the exterior due to extensive epidermal ulceration of the lesion surfaces resulted in hypoproteinaemia, weakness and death in several cases. The incidence increased to 17.6 % at 1 stage during the outbreak 13,14 . Twenty-three biopsies from sarcoid lesions of 19 affected animals were received and examined including 4 biopsies from 1 animal and 2 from another.…”

“…In 1995, an outbreak of equine sarcoid occurred in an inbred 18 population of Cape mountain zebra in the Gariep Dam Nature Reserve 13,14 . Most affected animals had 1 lesion and no animals had more than 4 lesions; the lesions were predominantly fibroblastic (57 %), but verrucous (16 %), nodular (10 %), or combinations thereof (Fig.…”

“…cottontail rabbit papillomavirus causes papillomas in the natural host which rarely progress to carcinomas, but often induces skin cancer in domestic rabbits, and BPV can induce fibroblastic tumours in C3H/eB mice and malignant fibroblastic tumours in hamsters 2 . It is recorded that a domestic short-haired cat developed a multinodular exophytic papillomatous lesion on the dorsum of its nose after prior actinic damage, the viral DNA of which sequenced with 98 % similarity to human papillomavirus type 9 13 . Six different papillomaviruses occur in cattle, namely types 1, 2 and 5 which cause cutaneous fibropapillomas, types 3 and 6 which cause skin papillomas, and type 4 which is associated with papillomas of the alimentary tract 3 .…”

Multicentric Squamous Cell Carcinoma In Situ Associated With Papillomavirus in a Ferret

“…6,17 Papillomavirus has been identified in these BISCs. 6,9,15,17,18,30 The purpose of this report is to describe the features of a case of multicentric squamous cell carcinoma in situ in a ferret associated with papillomavirus.…”

“…7 In cats, BISC has been associated with papillomavirus. 6,9,10,17,18,20 Papillomavirus is also implicated in the development of other feline skin neoplasms, such as cutaneous fibropapillomas (also called feline sarcoid), 26 oral papillomas, 28 cutaneous viral papillomas; 15,28,30 and invasive squamous cell carcinoma. 16,20,28 The lesions of BISC in cats are multicentric, similar to the distribution of the lesions observed in the present ferret.…”