Genetics, epigenetics, and allergic disease: A gun loaded by genetics and a trigger pulled by epigenetics

Bellanti, Joseph A.; Settipane, Russell A.

doi:10.2500/aap.2019.40.4206

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…It seems, therefore, that the interaction between genes and the environment will be the key research topic in years to come. As Bellanti has put it, “genetics loads the gun and epigenetics pulls the trigger” ( 26 ). For the convenience of this context in which epidemiology and genetics are linked, it might be put in a slightly different way: genetics is the bullet, epigenetics the trigger and firing mechanism, and the environment the hand that pulls the trigger.…”

Section: Geneticsmentioning

confidence: 99%

Grand challenges in genetics and epidemiology of allergic diseases: from genome to exposome and back

Garcia-Marcos

2024

Front. Allergy

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Section: Geneticsmentioning

confidence: 99%

Grand challenges in genetics and epidemiology of allergic diseases: from genome to exposome and back

Garcia-Marcos

2024

Front. Allergy

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“…Genetic background plays a significant role in the manifestation of most atopic diseases, whereas epigenetics matters greatly through three epigenetic mechanisms: DNA methylation, covalent posttranslational histone modifications, and micro-RNA-mediated gene silencing. Therefore, it may be essential for the interactions between various susceptibility genes, epigenetic modifications, immunologic processes, nerve impulses, and environmental factors [99]. However, explicit monogenic mutations linked with only anaphylaxis have not been found, but separate facts about some mutations causing anaphylaxis-like conditions and metabolic disturbances have continuously been accumulating [91].…”

Section: Food Allergies As Particular Atopic Conditionsmentioning

confidence: 99%

Food Allergies: New Challenges of Our Civilization

Klimov¹,

Cherevko²,

Koshkarova³

et al. 2023

Allergic Disease - New Developments in Diagnosis and Therapy

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People need to eat and digest food, and if they encounter a food allergy it is a real problem. Moreover, some people have a lifelong sensitization to certain products with the threat of anaphylaxis. This chapter considers different aspects of food allergies, allergenicity of dietary allergens, the significance of the gut microbiota and intestinal epithelium integrity, detailed processes of food sensitization, clinical phenotypes and management of food allergies, and, finally, mechanisms of oral tolerance. Fortunately, the gastrointestinal tract possesses robust tolerogenic mechanisms, in particular, the beneficial gut microbiota, as well as the autonomous enteric nervous system, which taken together with the gut immune cells and molecules may be called the enteric neuroimmune system (ENIS). The dual-allergen exposure hypothesis postulates that early oral exposure to food allergens induces tolerance, whereas exposure at non-gastrointestinal sites results in food sensitization and allergy development. In addition, a series of food allergic episodes does not look like a typical atopic disease and is a known exception to the rule conceived by evolution. However, the prevalence of food allergies is continuously growing, including severe cases, and it is a paradoxical problem in the face of evolution. This challenge is inherent to our civilization and will be resolved, thanks to new knowledge and technologies.

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“…Epigenetics plays a major pathogenetic role in the development and management of allergic diseases by superimposing its effects above the DNA molecule through interaction with susceptibility genes, environmental factors, and immunologic influences ( 29 ). Epigenetics holds the key to unravel the complex associations between phenotypes and endotypes of allergic disease by identifying effective therapies and diagnosis ( 30 ). Epigenetic modifications of genes are contributing to asthma induced by allergens, such as DNA methylation changes in DCs, can be passed to future generations ( 31 , 32 ).…”

Section: Allergic Diseasesmentioning

confidence: 99%

The emerging role of histone deacetylase 1 in allergic diseases

Wang

2022

Front. Immunol.

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Histone deacetylase 1 (HDAC1) is a unique member of the classes I HDACs and helps to regulate acute and chronic adaptation to environmental stimuli such as allergen, stress. Allergic diseases are complex diseases resulting from the effect of multiple genetic and interacting foreign substances. Epigenetics play an important role in both pathological and immunomodulatory conditions of allergic diseases. To be consistent with this role, recent evidence strongly suggests that histone deacetylase 1 (HDAC1) plays a critical role in allergic response. HDAC1 expression is stimulated by allergen and attributes to increase T helper 2 (Th2) cytokine levels, decrease Th1/Th17 cells and anti-inflammatory cytokine Interleukin-10 (IL-10), and TWIK-related potassium channel-1 (Trek-1) expression. This review focuses on the contribution of HDAC1 and the regulatory role in characterizing allergic endotypes with common molecular pathways and understanding allergic multimorbidity relationships, as well as addressing their potential as therapeutic targets for these conditions.

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Genetics, epigenetics, and allergic disease: A gun loaded by genetics and a trigger pulled by epigenetics

Cited by 8 publications

References 29 publications

Grand challenges in genetics and epidemiology of allergic diseases: from genome to exposome and back

Grand challenges in genetics and epidemiology of allergic diseases: from genome to exposome and back

Food Allergies: New Challenges of Our Civilization

The emerging role of histone deacetylase 1 in allergic diseases

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