Genetics and psychotic disorders: A fresh look at consanguinity

Dahdouh, Aïcha; Taleb, Mohammed; Blecha, Lisa; Benyamina, Aminé

doi:10.1016/j.ejmg.2015.12.010

Cited by 13 publications

(3 citation statements)

References 80 publications

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“…Situs Inversus Totalis does not have an ethnic predisposition reported being present in 0.01% of the world population, being considered rare [37]. The association of consanguine marriages with late start complex diseases, such as diabetes, cardiovascular disease and cancer, still needs further studies that point to preexisting risks [38] [39].…”

Section: Discussionmentioning

confidence: 99%

Population Structure of a Remnant Quilombo Community: An Analysis of the Inbreeding and Ethnic Admixture

Cruz¹,

Lima²,

Sousa³

2020

OALib

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The histories and oral traditions identify rural communities them as quilombos and that are currently denominated quilombo remnants in Brazil. The formation of these communities was usually carried out by a small number of individuals who remained isolated for generations. This study is an analysis of the effects of inbreeding and ethnic admixture in the remaining quilombo community Tucum in the South-Center region of the State of Bahia, in Brazil. The inbreeding values were obtained through inbreeding coefficients and genealogical database. The admixture analysis was conducted by phenotypic and cultural index. Other demographic genetic parameters were evaluated in the search for the better understanding of the population structure. A total of 489 individuals were analyzed for effective population size (N ef), inbreeding coefficient expected (Ø), inbreeding coefficient (F) and mean inbreeding coefficient (F) resulting in 384, 0, 0.144, 0.0086, respectively. The community presents 20.64% of consanguineous marriages and an inbreeding coefficient (r) of 0.288. These data are larger than those found in the total Brazilian population and to other traditional communities analyzed in the country. The admixture analysis revealed a Negroid Phenotypic Index (NPI) of 0.60 and the Negroid Cultural Index (NCI) of 0.33, lower than that found in other remnants. The isolation index (i) helps to understand this pattern of population structure, and the community studied was not a genetic isolate (i = 22.4) demonstrating a large migratory flow. Based on the data presented, it is possible to conclude that the community is not a genetic isolate, transcending the initial implications of the founding effect. However, the high migration does not prevent inbreeding and high rates of consanguineous marriages, influenced by cultural ethnic characters, which may change evolutionary mechanisms, as genetic drift, alleles fixation, natural selection (for preferential selection) and an increase in genetic diseases.

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Section: Discussionmentioning

confidence: 99%

Population Structure of a Remnant Quilombo Community: An Analysis of the Inbreeding and Ethnic Admixture

Cruz¹,

Lima²,

Sousa³

2020

OALib

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show abstract

“…This has been found in epidemiological research to account for genetic disorders with high levels of morbidity and mortality such as β-Thalassemia [ 18 , 39 ]. Dahdouh et al [ 16 ] draw attention to data suggesting ‘a significant association between consanguinity and mental disorders and a higher risk of schizophrenia or bipolar disorders among offspring from consanguineous couples’ (p. 104). Environmental factors associated with rapid industrialization and high serum levels of heavy metals have also been linked to learning disabilities in the UAE [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

Mental health literacy of school nurses in the United Arab Emirates

Al‐Yateem

Rossiter

Robb

et al. 2018

Int J Ment Health Syst

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BackgroundTo support promotion, prevention and early intervention for mental illness school nurses need to be mental health literate.MethodsThree hundred and thirty-nine school nurses employed in government and private schools from three Emirates in the UAE were surveyed. A culturally adapted Mental Health Literacy questionnaire comprising three vignettes of fictional characters meeting diagnostic criteria for the target conditions along with the Kessler Psychological Distress Scale (K10) was administered to ascertain school nurses’ ability to correctly identify the conditions and to elicit beliefs about helpfulness of treatment interventions and of health care providers for these conditions.ResultsLess than 50% of the respondents correctly identified the disorders presented, while accurate identification of evidence-based interventions was also limited. Correlations between level of psychological distress and level of inaccurate survey responses was also revealed, respondents who correctly identified the correct diagnosis of the vignette and the most appropriate interventions were those who had a significantly lower K10 score.ConclusionsLow levels of mental health literacy amongst respondents in combination with potential religious and cultural factors as reported in the literature, highlight the need for curriculum enhancements for future health professionals and a targeted program of culturally appropriate professional development focused on mental health promotion for those in clinical practice. The level of psychological distress noted in this cohort also signals a need to ensure that appropriate supports are available for clinical staff employed in schools.

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“…It is known that the main consequence of consanguinity is increased homozygosity for autosomal recessive disorders. The small number of epidemiological studies in consanguineous populations confirms that there exists a significant association between consanguinity and mental disorders among the resulting offspring [15] throughout the Middle East and South-East Asia. According to available data, couples of second cousins or closer and their offspring currently represent 10.4% of the world's population, thus resulting in increased frequencies of autosomal recessive disorders.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with Autism Spectrum Disorder: a case-control study in the Lebanese population

Bitar

Gerges

Kassab

et al. 2022

ebph

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Background: Genetic factors represent the major etiological contributor in Autism Spectrum Disorders (ASD) but several studies also support the involvement of environmental factors. This last hypothesis is reinforced by the evident increase in the prevalence of this disorder in the last decades. Thus, in our study, we aimed to identify the correlation between factors related to sociodemographic elements, to child and mother’s health and ASD in order to dress a best detailed profile of the patients. Methods: We conducted a case-control study including 64 Lebanese patients with ASD and 67 matched controls recruited from all the Lebanese districts. Our data has been analyzed by SPSS 23.0 and the statistical tests carried out were the Independent Sample t-test and the Chi-Square test. In addition, a multivariate logistic regression analysis has been carried out using variables that showed a p<0.05 in the bivariate analysis. Results: Our findings suggest that consanguinity (OR=4; 95% CI [1.3-12.04]), familial history of ASD (6.7 [1.1- 39.3]), stress during pregnancy (3.6 [1.5 8.2]) and fetal prematurity (6.3 [1.2-33.01]) were significantly associated with increased odds of ASD. However, our results have shown no association between siblings suffering from diseases such as mental retardation, child’s infections and ASD. Conclusion: This pilot study carried out in all the regions of Lebanon allowed us to shed the light on factors associated with ASD which might be preventable.

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Genetics and psychotic disorders: A fresh look at consanguinity

Cited by 13 publications

References 80 publications

Population Structure of a Remnant Quilombo Community: An Analysis of the Inbreeding and Ethnic Admixture

Population Structure of a Remnant Quilombo Community: An Analysis of the Inbreeding and Ethnic Admixture

Mental health literacy of school nurses in the United Arab Emirates

Factors associated with Autism Spectrum Disorder: a case-control study in the Lebanese population

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