Genetically Engineered Cell-Derived Nanoparticles for Targeted Breast Cancer Immunotherapy

Shi, Xiaojing; Cheng, Qinqin; Hou, Tianling; Han, Menglu; Smbatyan, Goar; Lang, Julie E.; Epstein, Alan L.; Lenz, Heinz‐Josef; Zhang, Yong

doi:10.1016/j.ymthe.2019.11.020

Cited by 166 publications

(138 citation statements)

References 37 publications

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“…For example, a new synthetic polyvalent antibody redirected exosome (SMART-EXO) was produced by using the transmembrane domain of human platelet-derived growth factor receptor to display two different types of monoclonal antibodies on the surface of an exosome. By targeting the CD3 receptor on the surface of T cells, SMART-EXOs with the breast cancer-related HER2 receptor and EGFR receptor can activate CTLs, which then exhibit highly potent and specific anti-tumor activity both in vitro and in vivo [163,164]. In addition, antigens can also be artificially transfected into exosomes.…”

Section: Exosomes: Underlying Targets For the Regulation Of Cancer Immentioning

confidence: 99%

Exosome-based immunotherapy: a promising approach for cancer treatment

et al. 2020

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In the era of the rapid development of cancer immunotherapy, there is a high level of interest in the application of cell-released small vesicles that stimulate the immune system. As cell-derived nanovesicles, exosomes show great promise in cancer immunotherapy because of their immunogenicity and molecular transfer function. The cargoes carried on exosomes have been recently identified with improved technological advances and play functional roles in the regulation of immune responses. In particular, exosomes derived from tumor cells and immune cells exhibit unique composition profiles that are directly involved in anticancer immunotherapy. More importantly, exosomes can deliver their cargoes to targeted cells and thus influence the phenotype and immune-regulation functions of targeted cells. Accumulating evidence over the last decade has further revealed that exosomes can participate in multiple cellular processes contributing to cancer development and therapeutic effects, showing the dual characteristics of promoting and suppressing cancer. The potential of exosomes in the field of cancer immunotherapy is huge, and exosomes may become the most effective cancer vaccines, as well as targeted antigen/drug carriers. Understanding how exosomes can be utilized in immune therapy is important for controlling cancer progression; additionally, exosomes have implications for diagnostics and the development of novel therapeutic strategies. This review discusses the role of exosomes in immunotherapy as carriers to stimulate an anti-cancer immune response and as predictive markers for immune activation; furthermore, it summarizes the mechanism and clinical application prospects of exosome-based immunotherapy in human cancer.

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Section: Exosomes: Underlying Targets For the Regulation Of Cancer Immentioning

confidence: 99%

Exosome-based immunotherapy: a promising approach for cancer treatment

et al. 2020

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“…A platform called synthetic multivalent antibodies retargeted exosome (SMART-Exo) was designed to redirect and activate T lymphocytes toward cancer cells. SMART-Exo displaying anti-CD3 together with anti-EGFR [174] or anti-HER2 antibodies [161] enabled simultaneous activation and redirection of T cells toward EGFR-or HER2-expressing breast cancer cells, respectively. The SMART-Exo therapy promoted antitumor immune responses both in vitro and in vivo [161,174] (Fig.…”

Section: Exosomes As Therapeutic Agents For Cancer Immunotherapymentioning

confidence: 99%

Exosomes as mediators of immune regulation and immunotherapy in cancer

2020

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Exosomes are nanosized extracellular vesicles of endosomal origin that enclose a multitude of functional biomolecules. Exosomes have emerged as key players of intercellular communication in physiological and pathological conditions. In cancer, depending on the context, exosomes can oppose or potentiate the development of an aggressive tumor microenvironment, thereby impacting tumor progression and clinical outcome. Increasing evidence has established exosomes as important mediators of immune regulation in cancer, as they deliver a plethora of signals that can either support or restrain immunosuppression of lymphoid and myeloid cell populations in tumors. Here, we review the current knowledge related to exosome-mediated regulation of lymphoid (T lymphocytes, B lymphocytes, and NK cells) and myeloid (macrophages, dendritic cells, monocytes, myeloidderived suppressor cells, and neutrophils) cell populations in cancer. We also discuss the translational potential of engineered exosomes as immunomodulatory agents for cancer therapy.

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“…They also authenticated caffold-mediated delivery of miR-219/miR-338 could enhance myelin formation after spinal cord injury (SCI) which can inhibit myelin formation by a phenomenon that MBP expression was more extensive in scaffolds that incorporated miR-219/miR-338 (73). Similarly, maybe transfection of miR-219/miR-338 into synthetic multivalent antibodies retargeted exosome which can control cellular immunity (74) to enhance axonal remyelination after nerve injuries in the central nervous system (CNS) to treat epileptic depression.…”

Section: Exosomes Are Expected To Be a Nano-therapeutic Agent For Depmentioning

confidence: 89%

The Progress in Diagnosis and Treatment of Exosomes and MicroRNAs on Epileptic Comorbidity Depression

et al. 2020

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The occurrence of epilepsy can increase the incidence of depression, and the risk of epilepsy in the patients with depression is also high, both of which have an adverse effect on the life and the psychology of the patient, which is not conducive to the prognosis of the patients with epilepsy. With lucubrating the function of exosomes and microRNAs, some scholars found that the exosomes and its microRNAs have development prospect in the diagnosis and treatment of the disease. MicroRNAs are involved in the regulation of seizures and depression, as biomarkers, that can significantly improve the management of epileptic patients and play a preventive role in the occurrence of epilepsy and epilepsy depressive disorder. Moreover, due to its regulation to genes, appropriate application of microRNAs may have therapeutic effect on epilepsy and depression with the characteristics of long distance transmission and stability of exosomes, to a certain extent. This provides a great convenience for the diagnosis and treatment of epileptic comorbidity depression.

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Genetically Engineered Cell-Derived Nanoparticles for Targeted Breast Cancer Immunotherapy

Cited by 166 publications

References 37 publications

Exosome-based immunotherapy: a promising approach for cancer treatment

Exosome-based immunotherapy: a promising approach for cancer treatment

Exosomes as mediators of immune regulation and immunotherapy in cancer

The Progress in Diagnosis and Treatment of Exosomes and MicroRNAs on Epileptic Comorbidity Depression

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