Genetically Engineered Antibody Functionalized Platinum Nanoparticles Modified CVD‐Graphene Nanohybrid Transistor for the Detection of Breast Cancer Biomarker, HER3

Rajesh, Rajesh; Gao, Zhaoli; Vishnubhotla, Ramya; Ducos, Pedro; Serrano, Madeline Díaz; Ping, Jinglei; Robinson, Matthew K.; Johnson, A. T. Charlie

doi:10.1002/admi.201600124

Cited by 36 publications

(22 citation statements)

References 53 publications

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“…This is attributed to the binding of PMA with SWNTs via p-p linkage through pyrene moiety, where an increased scattering by the basic NH 2 reduces the hole density in the SWNT channel. 32 A further decrease in charge mobility was found ($3 to $16 cm 2 V À1 s À1 ) with a major negative shift in the V Th due to the increased scattering on SWNTs by the NHS-ester activated PAMAM dendrimer in PAMAM modified SWNT-FET devices (Fig. S2(c)).…”

mentioning

confidence: 91%

High performance dendrimer functionalized single-walled carbon nanotubes field effect transistor biosensor for protein detection

Rajesh

Sharma

Puri

et al. 2016

Applied Physics Letters

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We report a single-walled carbon nanotube (SWNT) field-effect transistor (FET) functionalized with Polyamidoamine (PAMAM) dendrimer with 128 carboxyl groups as anchors for site specific biomolecular immobilization of protein antibody for C-reactive protein (CRP) detection. The FET device was characterized by scanning electron microscopy and current-gate voltage (I-Vg) characteristic studies. A concentration-dependent decrease in the source-drain current was observed in the regime of clinical significance, with a detection limit of ∼85 pM and a high sensitivity of 20% change in current (ΔI/I) per decade CRP concentration, showing SWNT being locally gated by the binding of CRP to antibody (anti-CRP) on the FET device. The low value of the dissociation constant (Kd = 0.31 ± 0.13 μg ml−1) indicated a high affinity of the device towards CRP analyte arising due to high anti-CRP loading with a better probe orientation on the 3-dimensional PAMAM structure.

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mentioning

confidence: 91%

High performance dendrimer functionalized single-walled carbon nanotubes field effect transistor biosensor for protein detection

Rajesh

Sharma

Puri

et al. 2016

Applied Physics Letters

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“…They used the modified graphene nanomesh in field-effect transistors (FETs) and succeeded at detecting a single SK-BR3 cancer cell. In another study, a FET test setting comprising a nanohybrid of platinum nanoparticles and CVD-grown graphene was used for electrical detection of HER3 biomarker down to 300 fg mL –1 …”

Section: Graphene-based Nanomaterialsmentioning

confidence: 99%

Applications of Two-Dimensional Nanomaterials in Breast Cancer Theranostics

Mohammadpour

Majidzadeh‐A

2020

ACS Biomater. Sci. Eng.

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Breast cancer is the leading cause of cancer-related mortality among women. Early stage diagnosis and treatment of this cancer are crucial to patients’ survival. In addition, it is important to avoid severe side effects during the process of conventional treatments (surgery, chemotherapy, hormonal therapy, and targeted therapy) and increase the patients’ quality of life. Over the past decade, nanomaterials of all kinds have shown excellent prospects in different aspects of oncology. Among them, two-dimensional (2D) nanomaterials are unique due to their physical and chemical properties. The functional variability of 2D nanomaterials stems from their large specific surface area as well as the diversity of composition, electronic configurations, interlayer forces, surface functionalities, and charges. In this review, the current status of 2D nanomaterials in breast cancer diagnosis and therapy is reviewed. In this respect, sensing of the tumor biomarkers, imaging, therapy, and theranostics are discussed. The ever-growing 2D nanomaterials are building blocks for the development of a myriad of nanotheranostics. Accordingly, there is the possibility to explore yet novel properties, biological effects, and oncological applications.

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“…Biosensors are able to identify tumor markers at such a low concentration (traces) where other techniques, such as image studies, may fail. Therefore, the numbers of studies towards the use of carbon nanomaterials as biosensors have increased [16,[82][83][84].…”

Section: Biosensorsmentioning

confidence: 99%

Carbon Nanomaterials for Breast Cancer Treatment

Casais-Molina

Cab

Canto

et al. 2018

Journal of Nanomaterials

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Currently, breast cancer is considered as a health problem worldwide. Furthermore, current treatments neither are capable of stopping its propagation and/or recurrence nor are specific for cancer cells. Therefore, side effects on healthy tissues and cells are common. An increase in the efficiency of treatments, along with a reduction in their toxicity, is desirable to improve the life quality of patients affected by breast cancer. Nanotechnology offers new alternatives for the design and synthesis of nanomaterials that can be used in the identification, diagnosis, and treatment of cancer and has now become a very promising tool for its use against this disease. Among the wide variety of nanomaterials, the scientific community is particularly interested in carbon nanomaterials (fullerenes, nanotubes, and graphene) due to their physical properties, versatile chemical functionalization, and biocompatibility. Recent scientific evidence shows the potential uses of carbon nanomaterials as therapeutic agents, systems for selective and controlled drug release, and contrast agents for diagnosing and locating tumors. This generates new possibilities for the development of innovative systems to treat breast cancer and can be used to detect this disease at much earlier stages. Thus, applications of carbon nanomaterials in breast cancer treatment are discussed in this article.

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Genetically Engineered Antibody Functionalized Platinum Nanoparticles Modified CVD‐Graphene Nanohybrid Transistor for the Detection of Breast Cancer Biomarker, HER3

Cited by 36 publications

References 53 publications

High performance dendrimer functionalized single-walled carbon nanotubes field effect transistor biosensor for protein detection

High performance dendrimer functionalized single-walled carbon nanotubes field effect transistor biosensor for protein detection

Applications of Two-Dimensional Nanomaterials in Breast Cancer Theranostics

Carbon Nanomaterials for Breast Cancer Treatment

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