Genetic variation within and between lines of diabetes-prone and non-diabetes-prone BB rats; allele distribution of 8 protein markers

Herberg, L.; Bieman, M. Den; Zutphen, L.F.M. van

doi:10.1258/002367791780808446

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…Firstly, spontaneous autoimmune diabetes was identified in 1974 in a Canadian colony and then led to the creation of two founder colonies from which all substrains have been derived including one of inbred Biobreeding Diabetes-Prone/Worcester (BBDP/Wor) and one of outbred Biobreeding Diabetes-Prone (BBDP) rats [22]. It was reported that immunologically and genetically distinct BB rat substrains were derived from several tertiary Biobreeding (BB) rat colonies [23] including Biobreeding/Ottawa Karlsburg (BB/OK) (BB/Pfd) and Biobreeding Spontaneously Hypertensive Rats (BB.SHR) [24–27]. Additionally, BB rats resistant to diabetes have been bred to act as controls.…”

Section: Bb Ratsmentioning

confidence: 99%

Experimental Diabetes Mellitus in Different Animal Models

Al-awar

Kupai

Veszelka

et al. 2016

Journal of Diabetes Research

229

217

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Animal models have historically played a critical role in the exploration and characterization of disease pathophysiology and target identification and in the evaluation of novel therapeutic agents and treatments in vivo. Diabetes mellitus disease, commonly known as diabetes, is a group of metabolic disorders characterized by high blood glucose levels for a prolonged time. To avoid late complications of diabetes and related costs, primary prevention and early treatment are therefore necessary. Due to its chronic symptoms, new treatment strategies need to be developed, because of the limited effectiveness of the current therapies. We overviewed the pathophysiological features of diabetes in relation to its complications in type 1 and type 2 mice along with rat models, including Zucker Diabetic Fatty (ZDF) rats, BB rats, LEW 1AR1/-iddm rats, Goto-Kakizaki rats, chemically induced diabetic models, and Nonobese Diabetic mouse, and Akita mice model. The advantages and disadvantages that these models comprise were also addressed in this review. This paper briefly reviews the wide pathophysiological and molecular mechanisms associated with type 1 and type 2 diabetes, particularly focusing on the challenges associated with the evaluation and predictive validation of these models as ideal animal models for preclinical assessments and discovering new drugs and therapeutic agents for translational application in humans.

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Section: Bb Ratsmentioning

confidence: 99%

Experimental Diabetes Mellitus in Different Animal Models

Al-awar

Kupai

Veszelka

et al. 2016

Journal of Diabetes Research

229

217

View full text Add to dashboard Cite

show abstract

“…Comprehensive studies of microsatellite variation are available for less than 10% of inbred strains, and little additional information is available in the literature on other DNA polymorphisms, such as single-nucleotide polymorphisms (SNPs) or randomly amplified polymorphic DNA markers. 26 In the early 1990s, one of the more detailed studies in inbred diabetes-prone BB rats showed, by the application of simple protein markers, that these did indeed carry some heterozygotic traits, 27 and some years later DNA fingerprinting also showed genetic heterogeneity in inbred BALB/c mice. 28 Furthermore, it is well known that separation of rodent strains into separated subcolonies gives rise to phenotypic variation even though skin grafting between the subcolonies still does not lead to rejections.…”

mentioning

confidence: 99%

Family relationship of female breeders reduce the systematic inter-individual variation in the gut microbiota of inbred laboratory mice

et al. 2010

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The gut microbiota (GM) may influence disease expression in several animal models for inflammatory diseases. It may therefore seem reasonable to pursue reduction in the number of animals used for individual studies by reducing the variation in the GM. Previous studies have shown that the composition of the GM is related to genetics to a certain extent. We hypothesized that the GM similarity in a group of mice born by mothers not being sisters would be lower than that in a group born by mothers being sisters. The lower similarity could lead to clustering of the GM of mice born by non-sisters according to their mothers, while such clustering would not be visible if the mothers were sisters. We used 16S rRNA gene (V3 region) polymerase chain reaction-derived amplicon profiling by denaturing gradient gel electrophoresis (DGGE) to study the GM composition in caecum samples of 33 eight-week-old C57BL/6Sca mice from a breeding set-up with dam breeders that were sisters, as well as caecum samples of 35 eight-week-old C57BL/6Sca mice from a breeding set-up with dam breeders that were not sisters. Principal component analysis revealed a significant difference between the litters from the breeding set-up with dam breeders that were not sisters, whereas no significant difference between the litters based on the breeding set-up with dam breeders that were sisters was observed. The results obtained indicate that the systematic variation in the GM of inbred mice can be reduced by increasing the family relatedness of the breeding pairs.

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“…In humans and NOD mouse, the combined action of many MHC alleles with the non-MHC genes results in their diabetogenic action [ 28 , 63 ]. The BB rats are the most valuable experimental animals for studying the genetic basis of type 1 diabetes [ 64 ] and also in intervention studies [ 65 , 66 ]. This sort of rodent had been derived from the outbred Wistar rodents in which spontaneous hyperglycemia and ketoacidosis occurred in the 1970s period.…”

Section: Main Textmentioning

confidence: 99%

Experimental animal models for diabetes and its related complications—a review

et al. 2021

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Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one of the fastest growing public health problems in the world. It is characterized by hyperglycemia, a condition with high glucose level in the blood plasma resulting from defects in insulin secretion or its action and in some cases both the impairment in secretion and also action of insulin coexist. Historically, animal models have played a critical role in exploring and describing malady pathophysiology and recognizable proof of targets and surveying new remedial specialists and in vivo medicines. In the present study, we reviewed the experimental models employed for diabetes and for its related complications. This paper reviews briefly the broad chemical induction of alloxan and streptozotocin and its mechanisms associated with type 1 and type 2 diabetes. Also we highlighted the different models in other species and other animals.

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Genetic variation within and between lines of diabetes-prone and non-diabetes-prone BB rats; allele distribution of 8 protein markers

Cited by 6 publications

References 12 publications

Experimental Diabetes Mellitus in Different Animal Models

Experimental Diabetes Mellitus in Different Animal Models

Family relationship of female breeders reduce the systematic inter-individual variation in the gut microbiota of inbred laboratory mice

Experimental animal models for diabetes and its related complications—a review

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