Genetic variation of the α2b‐adrenoceptor affects neural correlates of successful emotional memory formation

Urner, Maren; Wingen, Guido van; Franke, Barbara; Rijpkema, Mark; Fernández, Guillén; Tendolkar, Indira

doi:10.1002/hbm.21171

Cited by 17 publications

(10 citation statements)

References 39 publications

(46 reference statements)

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“…Findings of sustained amygdala activity in depressed populations (Siegle et al, 2007;van Wingen et al, 2010) indicate that similar effects could counteract or overshadow any amygdala involvement in moodcongruent stimulus detection. Moreover, our data are in line with studies using stress-induction in healthy controls (van Marle et al, 2009), where there is a shift of amygdala function towards heightened sensitivity with lower levels of emotional specificity following an experimental stress-induction procedure, a pattern of results suggestive for a state of indiscriminate hyper-vigilance. The idea of amygdala hyperactivity during an acute mood-state that will put more brain systems on alert is very well in line with recent theories of depression (Whalen et al, 2002).…”

Section: Discussionsupporting

confidence: 90%

“…The idea of amygdala hyperactivity during an acute mood-state that will put more brain systems on alert is very well in line with recent theories of depression (Whalen et al, 2002). Our findings together with those of van Marle et al (2009) add to that by showing that a mood-induced indiscriminate hyper-vigilance of amygdala seems to have a general adaptive value that also applies to the general population.…”

Section: Discussionsupporting

confidence: 90%

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How mood challenges emotional memory formation: An fMRI investigation

et al. 2011

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

How mood challenges emotional memory formation: An fMRI investigation

et al. 2011

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“…These results suggest that this polymorphism did not affect these processes. Moreover, a recent study showed that the modulations by + 901 Ins/Del of the neural correlations of emotional memory mainly emerge in the formation phase (Urner et al, 2011). However, the polymorphism did not significantly affect arousal for encoding emotion valence (Naudts et al, 2012) or for arousal ratings of emotional versus neutral photographs (De Quervain et al, 2007).…”

Section: Discussionmentioning

confidence: 92%

A 9-nucleotide Ins/Del in ADRA2B modulates orientation of attention to facial expressions and emotional words

Xi¹,

Gong²,

She³

et al. 2014

Behavioural Pharmacology

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Norepinephrine is involved in the arousal of attention and the treatment of affective disorders. Therefore, we hypothesized that adrenergic receptors underpinned individual differences in attention regulation and emotional processes of healthy populations. Here, we investigated to what extent the expression of ADRA2B, an adrenergic receptor, modulated attention regulation and emotional processes. We evaluated orientation of attention, emotion regulation, and pleasantness ratings of expressions and words in 665 college students, and then genotyped the +901 Ins/Del variants in ADRA2B of these participants. The results indicated that +901 Ins/Del significantly modulated orientation of attention to facial expressions and emotional words, such that the Del allele facilitated reorientation to the originally attended locations. However, this polymorphism exerted no significant effects on emotional regulation of attention and pleasantness ratings of emotional stimulus. These findings suggest that ADRA2B is closely related to the individual difference in human attention orientation, but not to the individual difference in emotional processing.

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“…Furthermore, variants of the ADRB2B gene have been associated with activations in these brain regions, particularly the right inferior frontal gyrus, the insula, and the basal ganglia system. For example, the + 901 Del/Ins variant of the ADRA2B gene modulates the neural activity of the amygdala/insula/inferior frontal gyrus (de Quervain et al, 2007;Rasch et al, 2009;Cousijn et al, 2010;Urner et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Haplotype Polymorphism in the Alpha-2B-Adrenergic Receptor Gene Influences Response Inhibition in a Large Chinese Sample

Lei

Chen

et al. 2012

Neuropsychopharmacol

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Response inhibition refers to the suppression of inappropriate or irrelevant responses. It has a central role in executive functions, and has been linked to a wide spectrum of prevalent neuropsychiatric disorders. Increasing evidence from neuropharmacological studies has suggested that gene variants in the norepinephrine neurotransmission system make specific contributions to response inhibition. This study genotyped five tag single-nucleotide polymorphisms covering the whole alpha-2B-adrenergic receptor (ADRA2B) gene and investigated their associations with response inhibition in a relatively large healthy Chinese sample (N=421). The results revealed significant genetic effects of the ADRA2B conserved haplotype polymorphisms on response inhibition as measured by stop-signal reaction time (SSRT) (F(2, 418)=5.938, p=0.003). Individuals with the AAGG/AAGG genotype (n=89; mean SSRT=170.2 ms) had significantly shorter SSRTs than did those with either the CCAC/AAGG genotype (n=216; mean SSRT=182.4 ms; uncorrected p=0.03; corrected p=0.09) or the CCAC/CCAC genotype (n=116; mean SSRT=195.8 ms; corrected p<0.002, Cohen's d=0.51). This finding provides the first evidence from association research in support of a critical role of the norepinephrine neurotransmission system in response inhibition. A better understanding of the genetic basis of response inhibition would allow us to develop more effective diagnosis, treatment, and prevention of deficient or underdeveloped response inhibition as well as its related prevalent neuropsychiatric disorders.

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Genetic variation of the α2b‐adrenoceptor affects neural correlates of successful emotional memory formation

Abstract: Our results demonstrate that the ADRA2B polymorphism influences emotional memory formation but not memory retrieval in the amygdala and left inferior frontal gyrus.

Cited by 17 publications

References 39 publications

How mood challenges emotional memory formation: An fMRI investigation

How mood challenges emotional memory formation: An fMRI investigation

A 9-nucleotide Ins/Del in ADRA2B modulates orientation of attention to facial expressions and emotional words

Haplotype Polymorphism in the Alpha-2B-Adrenergic Receptor Gene Influences Response Inhibition in a Large Chinese Sample

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