How mood challenges emotional memory formation: An fMRI investigation

Fitzgerald, Daniel A.; Arnold, Jennifer; Becker, Eni S.; Speckens, Anne; Rinck, Mike; Rijpkema, Mark; Fernández, Guillén; Tendolkar, Indira

doi:10.1016/j.neuroimage.2011.02.061

Cited by 47 publications

(44 citation statements)

References 54 publications

(61 reference statements)

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“…In particular, participants labeled faces as happier when they were in an elated mood and as sadder when a negative mood was induced. Similarly, induced recollection of emotional autobiographical memories significantly affected the number of emotional faces detected by subjects, increasing the detection of frowning faces after sad mood induction and of happy faces after positive mood induction [5]. Together with other similar findings [6] [7] [5], these studies suggest that individuals in a negative affective state recognize more negative stimuli compared to positive or neutral stimuli, whereas individuals in a positive affective state tend to be more accurate in recognizing positive targets.…”

Section: Introductionsupporting

confidence: 61%

Implicit Processing of Visual Emotions Is Affected by Sound-Induced Affective States and Individual Affective Traits

et al. 2014

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The ability to recognize emotions contained in facial expressions are affected by both affective traits and states and varies widely between individuals. While affective traits are stable in time, affective states can be regulated more rapidly by environmental stimuli, such as music, that indirectly modulate the brain state. Here, we tested whether a relaxing or irritating sound environment affects implicit processing of facial expressions. Moreover, we investigated whether and how individual traits of anxiety and emotional control interact with this process. 32 healthy subjects performed an implicit emotion processing task (presented to subjects as a gender discrimination task) while the sound environment was defined either by a) a therapeutic music sequence (MusiCure), b) a noise sequence or c) silence. Individual changes in mood were sampled before and after the task by a computerized questionnaire. Additionally, emotional control and trait anxiety were assessed in a separate session by paper and pencil questionnaires. Results showed a better mood after the MusiCure condition compared with the other experimental conditions and faster responses to happy faces during MusiCure compared with angry faces during Noise. Moreover, individuals with higher trait anxiety were faster in performing the implicit emotion processing task during MusiCure compared with Silence. These findings suggest that sound-induced affective states are associated with differential responses to angry and happy emotional faces at an implicit stage of processing, and that a relaxing sound environment facilitates the implicit emotional processing in anxious individuals.

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Section: Introductionsupporting

confidence: 61%

Implicit Processing of Visual Emotions Is Affected by Sound-Induced Affective States and Individual Affective Traits

et al. 2014

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“…The mood induction procedure was adapted from Fitzgerald et al (2011), selecting three clips from the movie ‘Sophie’s Choice’ with different durations (i.e. 12, 6 and 5 min).…”

Section: Methodsmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation modulates the impact of a negative mood induction

Möbius

Lacomblé

Meyer

et al. 2016

Soc Cogn Affect Neurosci

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High frequency repetitive Transcranial Magnetic Stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) has been found to alleviate depressive symptoms. However, the mechanisms driving these effects are still poorly understood. In the current study, we tested the idea that this intervention protects against negative mood shifts following emotional provocation. We furthermore explored changes in EEG activity (frontal alpha asymmetry) and effects on attentional processing (emotional Stroop). To this end, 23 healthy individuals participated in two sessions separated by one week, whereby they once received 15 min of 10Hz rTMS stimulation (1500 pulses) at 110% of the individual motor threshold, and once sham stimulation. Then, negative mood was induced using sad movie clips. The results revealed a significantly stronger mood decline following rTMS compared to sham stimulation. No changes were observed in frontal alpha asymmetry and attentional processing. Our findings are at odds with the view that high frequency rTMS over the left DLPFC directly protects against the induction of negative mood, but rather suggest that it enhances the effects of emotional provocation. Possibly, in healthy young individuals, this stimulation protocol heightens susceptibility to mood induction procedures in general.

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“…Experimental sad mood induction allows assessing the neural correlates of emotional memory while aligning subjects in a reduced emotional state (Lewis et al, 2005;Fitzgerald et al, 2011). It can be combined with investigation of antidepressant effects recruiting healthy subjects in a within-subject, crossover design, which would not be feasible in a patient sample.…”

Section: Introductionmentioning

confidence: 99%

Short-Term Duloxetine Administration Affects Neural Correlates of Mood-Congruent Memory

Tendolkar

Wingen

Urner

et al. 2011

Neuropsychopharmacol

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It is unknown how antidepressants reverse mood-congruent memory bias, a cognitive core factor causing and maintaining depression. Using a double-blind, placebo-controlled, cross-over design, we investigated the effect of a short-term treatment (14 days) with the dual reuptake inhibitor duloxetine on neural correlates of mood-congruent and mood-incongruent memory formation and retrieval in healthy volunteers who underwent a sad mood induction procedure. Duloxetine did not affect acute mood state or memory performance, but interacted with brain processes mediating mood-congruent memory. It decreased activity related to successful memory formation for mood-congruent and -incongruent items in a set of brain regions comprising the putamen and the middle frontal gyrus, as well as the middle and the anterior cingulate cortex. Duloxetine specifically increased amygdala activity related to successful memory retrieval for mood-incongruent items. Here we show that short-term administration of duloxetine affects the neural correlates of emotional memory formation and retrieval in a set of brain regions whose processing is related to affective state and its regulation. While duloxetine suppressed the neural correlates of emotional memory formation in general, it specifically enhanced amygdala processes associated with mood-incongruent memory retrieval. This pattern of results shows how an antidepressant may reduce emotional memory formation and reverse mood-congruent processing biases at retrieval.

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How mood challenges emotional memory formation: An fMRI investigation

Cited by 47 publications

References 54 publications

Implicit Processing of Visual Emotions Is Affected by Sound-Induced Affective States and Individual Affective Traits

Implicit Processing of Visual Emotions Is Affected by Sound-Induced Affective States and Individual Affective Traits

Repetitive transcranial magnetic stimulation modulates the impact of a negative mood induction

Short-Term Duloxetine Administration Affects Neural Correlates of Mood-Congruent Memory

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