Genetic variation of the norovirus GII-4 genotype associated with a large number of outbreaks in Chiba prefecture, Japan

Okada, Morio; Ogawa, Tomoko; Yoshizumi, Hiroaki; Kubonoya, Hiroko; Shinozaki, K.

doi:10.1007/s00705-007-1028-8

Cited by 22 publications

(19 citation statements)

References 11 publications

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“…1B) (20,21), has been used to monitor the genotypes of NoV strains in many countries, including Japan. Therefore, we used published sequence information on the N/S region to verify the (26,34,50) were grouped with sequences from the cluster I 2006b strains (Fig. 2B, cluster I, green boxes).…”

Section: Resultsmentioning

confidence: 99%

Identification of Monomorphic and Divergent Haplotypes in the 2006-2007 Norovirus GII/4 Epidemic Population by Genomewide Tracing of Evolutionary History

Motomura

Oka

Yokoyama

et al. 2008

J Virol

103

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Section: Resultsmentioning

confidence: 99%

Identification of Monomorphic and Divergent Haplotypes in the 2006-2007 Norovirus GII/4 Epidemic Population by Genomewide Tracing of Evolutionary History

Motomura

Oka

Yokoyama

et al. 2008

J Virol

103

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“…GII-4 was also the prevalent genotype that circulated in Belém in another study of samples collected in the years of 1992-1994 and 1998-2000 (data not shown). Many articles report a marked increase on the circulation of GII-4 strains since the 1990s, with growing genetic variability, that were related either with extensive 5,31,43 outbreaks and sporadic cases .…”

Section: Frommentioning

confidence: 99%

Molecular characterization of norovirus, sapovirus and astrovirus in children with acute gastroenteritis from Belém, Pará, Brazil

et al. 2010

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Molecular characterization of norovirus, sapovirus and astrovirus in children with acute gastroenteritis from Belém, Pará, Brazil Caracterização molecular de norovírus, sapovírus e astrovírus em crianças com gastroenterite aguda em Belém, Pará, Brasil Caracterización molecular de norovirus, sapovirus y astrovirus en niños con gastroenteritis aguda en Belém (Pará, Brasil) http://revista.iec.pa.gov.br Glicélia Cruz Aragão ABSTRACTThe importance of norovirus (NoVs), sapovirus (SaVs) and human astrovirus (HAstVs) as causes of gastroenteritis outbreaks is already well-defined, but a few studies have described sporadic cases of acute gastroenteritis caused by these viral entities. The aim of this study was to determine the role of these viruses in the etiology of acute gastroenteritis in children enrolled to participate in hospital -and emergency department -based intensive surveillance carried out in Belém, Brazil, from March to September 2003. A total of 305 stool specimens from patients with severe gastroenteritis were collected and screened by reverse transcription followed by polymerase chain reaction (RT-PCR), using the specific primers Mon 269 and Mon 270 for HAstVs, p289 and p290 for human calicivirus (HuCVs), and Mon 431/433 and Mon 432/434 for NoVs. Sequencing of RT-PCR HAstV, HuCV and NoV amplicons was carried out using the same primers. Of the 305 samples tested, 96 (31.5%) were positive, with 51 diagnosed as HuCVs, 40 as HAstVs and five as mixed infections. Of the 56 (18.4%) HuCVs sequenced, 30 were NoVs (9.8%) of genogroups and 15 (4.9%) were SaVs of types GI-1, GI-2 and GII-1. HAstVs, including genotypes 1, 8 and 2, were detected in 45 (14.7%) samples. This study has highlighted the importance of these viruses as causes of acute gastroenteritis and established the circulation of different genotypes during the study period. These results reinforce the need for establishing an intensive surveillance for gastroenteritis caused by these viruses to assess the burden of disease and to monitor the circulation of genotypes.

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“…This antigenic variation and accompanying host immune evasion may contribute to GII.4 persistence in human populations (8,39). Additional compelling evidence for long-term protective immunity to norovirus infection also comes from reports indicating that periods of "high norovirus activity" correlated with the emergence of new GII.4 strains (1,5,29,47,55,62) and are followed by years characterized by decreased numbers of outbreaks. These data suggest that herd immunity may be an important regulator of GII.4 norovirus evolution and persistence in human populations (8,39).…”

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confidence: 99%

Norovirus GII.4 Strain Antigenic Variation

Lindesmith

Donaldson

Baric

2011

J Virol

149

165

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Genetic variation of the norovirus GII-4 genotype associated with a large number of outbreaks in Chiba prefecture, Japan

Abstract: Between October and December, 2006, high activity of three genetically distinct norovirus GII-4 subtypes was observed in Chiba prefecture, Japan. One subtype was newly identified in this period and it was detected in 85% of outbreaks.

Cited by 22 publications

References 11 publications

Identification of Monomorphic and Divergent Haplotypes in the 2006-2007 Norovirus GII/4 Epidemic Population by Genomewide Tracing of Evolutionary History

Identification of Monomorphic and Divergent Haplotypes in the 2006-2007 Norovirus GII/4 Epidemic Population by Genomewide Tracing of Evolutionary History

Molecular characterization of norovirus, sapovirus and astrovirus in children with acute gastroenteritis from Belém, Pará, Brazil

Norovirus GII.4 Strain Antigenic Variation

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