Genetic variation of plasticity in human motor cortex

Missitzi, J.; Gentner, R.; Geladas, Nickos D.; Claßen, Joseph; Klissouras, Vassilis

doi:10.1016/j.brs.2008.06.161

Cited by 2 publications

(1 citation statement)

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“…Current results extend the influence of genes also to functional parameters or features rather than morphology/anatomy, suggesting that a significant proportion of variability in the individual responses to PP protocol could be attributable to biological differences between subjects, such as different endophenotypes (Wassermann, 2002). In the same vein, a high interindividual variability associated to a relatively high intraindividual stability in motor cortical plasticity, as assessed by paired associative stimulation (PAS) (Fratello et al, 2006) can be explained by the genetic determination of some PAS-induced excitability changes (Missitzi et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Heritability of Intracortical Inhibition and Facilitation

Pellicciari¹,

Veniero²,

Marzano³

et al. 2009

Journal of Neuroscience

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The present twin study investigates heritability of motor cortex excitability, measured by the paired pulse transcranial magnetic stimulation technique. Specifically, intracortical facilitation (ICF) and inhibition (ICI) and corticospinal excitability were tested in monozygotic (MZ), dizygotic (DZ), and unrelated pairs (UP). Robust ICF and ICI effects were found, with a higher similarity of MZ than DZ and UP pairs. Heritability estimates (h 2 ) were 0.80 for ICI and 0.92 for ICF. However, corticospinal excitability did not show significant differences between MZ and DZ pairs, whereas both significantly differed from UP. Hence, the study provides-for the first time-a clear evidence of heritable individual differences in motor cortex excitability.

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Section: Discussionmentioning

confidence: 99%