Modulation of cortical excitability induced by repetitive transcranial magnetic stimulation: Influence of timing and geometrical parameters and underlying mechanisms

Pell, Gaby S.; Roth, Yiftach; Zangen, Abraham

doi:10.1016/j.pneurobio.2010.10.003

Cited by 329 publications

(275 citation statements)

References 401 publications

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“…regarding LTP-like functioning (45,65). We found that the DA notch (46), as a signature of intracortical inhibition counteracting the excitatory visual input during the rising phase of cortical responses (24), was diminished (reversible through low-frequency TMS).…”

Section: Discussionmentioning

confidence: 74%

Voltage-sensitive dye imaging of transcranial magnetic stimulation-induced intracortical dynamics

Kozyrev

Eysel

Jancke

2014

Proc. Natl. Acad. Sci. U.S.A.

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Transcranial magnetic stimulation (TMS) is widely used in clinical interventions and basic neuroscience. Additionally, it has become a powerful tool to drive plastic changes in neuronal networks. However, highly resolved recordings of the immediate TMS effects have remained scarce, because existing recording techniques are limited in spatial or temporal resolution or are interfered with by the strong TMS-induced electric field. To circumvent these constraints, we performed optical imaging with voltage-sensitive dye (VSD) in an animal experimental setting using anaesthetized cats. The dye signals reflect gradual changes in the cells' membrane potential across several square millimeters of cortical tissue, thus enabling direct visualization of TMS-induced neuronal population dynamics. After application of a single TMS pulse across visual cortex, brief focal activation was immediately followed by synchronous suppression of a large pool of neurons. With consecutive magnetic pulses (10 Hz), widespread activity within this "basin of suppression" increased stepwise to suprathreshold levels and spontaneous activity was enhanced. Visual stimulation after repetitive TMS revealed long-term potentiation of evoked activity. Furthermore, loss of the "deceleration-acceleration" notch during the rising phase of the response, as a signature of fast intracortical inhibition detectable with VSD imaging, indicated weakened inhibition as an important driving force of increasing cortical excitability. In summary, our data show that high-frequency TMS changes the balance between excitation and inhibition in favor of an excitatory cortical state. VSD imaging may thus be a promising technique to trace TMS-induced changes in excitability and resulting plastic processes across cortical maps with high spatial and temporal resolutions. (1) (TMS) has become a frequently used method for noninvasive diagnostics, therapeutic treatment, and intervention for neurorehabilitation of neurological disorders (2-8). Additionally, TMS has proved a valuable tool in basic brain research as its perturbative effects allow area-selective manipulation of immediate cortical function (9-11), as well as its long-lasting alteration through plasticity and learning protocols (12, 13). However, direct measurements of the TMS-induced cortical dynamics at highly resolved spatiotemporal scales are missing because "online approaches" (14), using modern neuroimaging techniques such as functional MRI (fMRI) (15-18), magnetoencephalography (19), EEG (20), and near-infrared (21) or intrinsic optical imaging (22), are limited in either spatial or temporal resolutions or in both.Here we overcame these limitations, using optical imaging with voltage-sensitive dyes (VSD), which exploits the dye's property to transduce gradual changes in voltage across neuronal membranes into fluorescent light signals. In contrast to imaging methods applicable in humans, this method is invasive but allows avoiding the commonly experienced contamination of signals by artifacts due to the strong ...

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Section: Discussionmentioning

confidence: 74%

Voltage-sensitive dye imaging of transcranial magnetic stimulation-induced intracortical dynamics

Kozyrev

Eysel

Jancke

2014

Proc. Natl. Acad. Sci. U.S.A.

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“…It has been found that high frequency rTMS may be able to increase cortical excitability and modulate dopamine release [45,46]. A meta-analysis of nine trials, involving 213 patients with schizophrenia, revealed a significant improvement in negative symptoms that was stronger for rTMS, than for sham.…”

Section: Tms In Schizophreniamentioning

confidence: 99%

Neuromodulation in Psychiatric disorders: recent findings and clinical implications

Andrade¹,

Mota²,

Ferreira³

et al. 2017

IJCNMH

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The potential therapeutic value of electricity to treat neuropsychiatric disorders has been known for a long time. However, it is only recently that it has been successfully applied to these clinical conditions. Two of the most promising neuromodulation techniques are the deep brain stimulation (DBS) and the transcranial magnetic stimulation (TMS). DBS uses a high-frequency stimulation that causes a "reversible lesion" and is increasingly becoming an alternative for lesional surgery for its better balance between efficacy, tolerability and safety, and has consistently been shown to improve depressive and obsessive symptoms. TMS is a non-invasive and safe approach that has been approved for the treatment of major depressive disorder and for auditory-verbal hallucinations in schizophrenia and is being studied in several other psychiatric disorders, such as obsessive-compulsive disorder, eating disorders and negative symptoms of schizophrenia.In the current paper, we will review recent evidence of these two neuromodulation techniques, its main psychiatric indications and present two brief case reports to further illustrate its clinical applicability.

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“…After-effects of rTMS depend on the frequency, intensity, direction of induced current, total number of pulses and other factors (see Pell et al [98] for review). Typically, rTMS delivered at low frequencies (i.e.…”

Section: Paired Associative Stimulation (Pas)mentioning

confidence: 99%

Transcranial Magnetic Stimulation to Investigate Motor Cortical Circuitry and Plasticity in Spinal Cord Injury

Bailey

Mi²,

Aimee³

et al. 2014

JNSK

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Spinal cord injury may lead to complete or incomplete damage to ascending sensory and/or descending motor pathways and therefore alter neural circuits of the primary motor cortex. Transcranial magnetic stimulation (TMS) is a valuable tool for investigating the function of neural circuitry within primary motor cortex and also for promoting plasticity in these circuits for the ultimate purpose of improving the control of movement. For spinal cord injury, information about motor cortical circuits and TMS approaches to induce plasticity in these circuits is steadily emerging. In this review, we discuss TMS investigations of motor cortical circuitry and review TMS approaches to promote plasticity in motor cortical circuitry in spinal cord injury.

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Modulation of cortical excitability induced by repetitive transcranial magnetic stimulation: Influence of timing and geometrical parameters and underlying mechanisms

Cited by 329 publications

References 401 publications

Voltage-sensitive dye imaging of transcranial magnetic stimulation-induced intracortical dynamics

Voltage-sensitive dye imaging of transcranial magnetic stimulation-induced intracortical dynamics

Neuromodulation in Psychiatric disorders: recent findings and clinical implications

Transcranial Magnetic Stimulation to Investigate Motor Cortical Circuitry and Plasticity in Spinal Cord Injury

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