Genetic Variation in Taste Receptor Genes (SCNN1B, TRPV1) and Its Correlation with the Perception of Saltiness in Normotensive and Hypertensive Adults

Abstract

Background. Different taste preferences correlated with genetic variations may lead to food consumption patterns that contribute to nutrient-related health outcomes such as hypertension. Objectives. The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) in the salt taste receptor genes SCNN1B and TRPV1 affect salt taste perception among normotensive and hypertensive people. Materials and Methods. We conducted a cross-sectional case control study by design consisting of a normotensive and hypertensive group. Participants were 253 adults with age range of 20–82 residing in Mississippi, USA. For each of 128 normotensives and 125 hypertensives, the salt taste recognition threshold and salt taste receptor genotype were determined. Results. The hypertensive group had a higher salt taste recognition threshold than the normotensive group ( P < 0.001 ). The polymorphism of TRPV1, rs4790522, with the AA genotype was associated with a higher salt recognition threshold (lower salt taste sensitivity) in people with hypertension and obesity. Moreover, the polymorphism of TRPV1, rs8065080, and SCNN1B, rs239345, genes were associated with a risk of hypertension ( P = 0.016 and P = 0.024 ). Conclusion. Correlations between SNPs, salt taste sensitivity, and hypertension risk were observed. People with hypertension had a higher salt taste threshold than those with normotension.

Salt-Taste Polymorphism <i>TRPV1</i>-rs8065080 Is Associated with Increased Likelihood of Depression in an Elderly Cohort

“…This indicates there may be a threshold effect where the impacts of genotypic variance manifest in the context of poor diet quality in males, or a sex hormone-specific interaction may be occurring. As a missense mutation [99], TRPV1-rs8065080 may be modifying protein structure and function [57,58,[100][101][102][103]. Neuropathic pain irregularities such as higher tolerance to cold pain [101,102], lower risk of wheezing in childhood asthma [100], and protective effects against hypertension (TRPV1-C allele) [103] are associated with the SNP.…”

Cannabis Pharmacogenomics: A Path to Personalized Medicine

“…The SNP of TRPV1 rs222741 was correlated with migraines in the Spanish population [ 110 ]. Another polymorphism of TRPV1 , rs8065080 , was connected to a risk of hypertension [ 111 ]. The variation of TRPV1 , rs4790522 , was associated with a higher salt recognition threshold in people with hypertension and obesity [ 111 ].…”

“…Another polymorphism of TRPV1 , rs8065080 , was connected to a risk of hypertension [ 111 ]. The variation of TRPV1 , rs4790522 , was associated with a higher salt recognition threshold in people with hypertension and obesity [ 111 ]. A significant association was reported for TRPV1 SNP rs222747 and tumor necrosis factor (TNF) levels in the cerebrospinal fluid of MS patients.…”

Targeting temperature-sensitive transient receptor potential channels in hypertension: far beyond the perception of hot and cold

“…Genetic factors have been associated with the TRPV1 gene polymorphism, leading to an increased risk of developing hypertension and dyslipidemia [253][254][255]. However, environmental factors, including air pollution, can influence cardiovascular function.…”