Genetic variation in low-dose effects of neonatal DES exposure in female rats

Ohmukai, Hideo; Negura, Tsukasa; Tachibana, Shigehiro; Ohta, Ryo

doi:10.1016/j.reprotox.2017.07.005

Cited by 4 publications

(1 citation statement)

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“…To examine the effects of a low dose of diethylstilbestrol (DES), which is a synthetic non-steroidal estrogen, female neonates from HAA and LAA lines were administered DES daily by oral gavage for the first 5 days after birth [26]. Accelerated puberty and excessive body weight gains were observed only in LAA rats treated with a low dose of DES, which suggests that neonatal DES exposure varies by genetic background.…”

Section: Endocrine Disrupting Effects Onthe Next Generationmentioning

confidence: 99%

Hatano rats selectively bred for high- and low-avoidance learning: an overview

Ohta

Kojima

2019

Exp. Anim.

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This review compiles the results of a series of studies on Hatano high- and low-avoidance animals (HAA and LAA, respectively) established at the Hatano Research Institute, Food and Drug Safety Center, Japan. The HAA and LAA lines were selected and bred from Sprague Dawley rats for high and low avoidance learning, respectively, in a shuttlebox task since 1985. Although Hatano rats were selected only based on their behavioral traits in the active avoidance task, strain differences between the HAA and LAA lines were also observed in their stress responses and reproductive functions. However, the most noticeable finding of Hatano rats is a matched result in both active and passive avoidance tasks. The HAA and LAA lines are useful for next-generation toxicological studies, because the hereditary characters of behaviors or endocrine functions are well controlled.

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Section: Endocrine Disrupting Effects Onthe Next Generationmentioning

confidence: 99%