Hatano rats selectively bred for high- and low-avoidance learning: an overview

Ohta, Ryo; Kojima, Kohich

doi:10.1538/expanim.18-0148

Cited by 9 publications

(3 citation statements)

References 43 publications

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“…In addition to natural selection, artificial selection allows humans to create populations of animals with given individual characteristics. Therefore, in experimental physiology and pharmacology, selective strains of mice and rats with behavioral features are used, for example, with different levels of motor activity [2,3] , anxiety [4][5][6] , or learnability [7,8] . In addition to genetic mechanisms of inheritance, various epigenetic influences can affect the formation of individual behavioral characteristics in offspring.…”

Section: Introductionmentioning

confidence: 99%

Expression of Exploratory Activity of Rat Offspring Depends On the Expression of Exploratory Activity of Their Parents at the Moment of Mating

Sudakov¹,

Bogdanova²,

Назарова³

2023

Preprint

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The aim of this work was to study the, so far, unexplored possibility that non-genetic inheritance of animal behavioral characteristics could depend on the state of the parents at the time of conception, by studying inheritance of high and low motor and exploratory activity in the first generation of rats. In this study, we measured the levels of motor and exploratory activity in rats at the ages of 2 and 5 months. Male and female rats were mated at the age of 5 months. The following groups were used: male and female rats with high motor activity at ages of 2 and 5 months (ACT+); male and female rats with high activity at the age of 2 months, but low activity at the age of 5 months (ACT–); male and female rats with low activity at the ages of 2 and 5 months (PAS–); male and female rats with low activity at the age of 2 months, but high activity at the age of 5 months (PAS+). Significant differences in the severity of exploratory activity were found between the offspring of ACT+ and ACT– rats. Moreover, these differences were observed only in males, and not in females. Differences between the offspring of PAS+ and PAS– rats were observed in both the male and female rats. The motor activity of animals in the period from 20 minutes after the start of registration did not differ between groups. Thus, it can be considered that individual characteristics of general motor activity are due to genetically inherited factors, while differences in the level of exploratory activity, apparently, are formed due to non-genetic influences from parents during mating.

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Section: Introductionmentioning

confidence: 99%

Expression of Exploratory Activity of Rat Offspring Depends On the Expression of Exploratory Activity of Their Parents at the Moment of Mating

Sudakov¹,

Bogdanova²,

Назарова³

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…In addition to natural selection, we can use artificial selection to create populations of animals with given individual characteristics. Thus, in experimental physiology and pharmacology, selective strains of mice and rats with distinctive behavioral features can be used, for example, which differ in the level of motor activity [ 2 , 3 ], anxiety [ 4 , 5 , 6 ], or learning ability [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Cross-Generational Impact of Epigenetic Male Influence on Physical Activity in Rat

Sudakov

Bogdanova

Назарова

2022

Biology

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The aim of this work was to study whether epigenetic events at conception influence the formation of behavioral features found in adult rats. First generational inheritance of activity level, anxiety like behavior, and learning ability was studied. To separate genetic and non-genetic inheritance, mating of males and females with average motor activity was carried out in the presence anesthetized or conscious males with high or low activity. Our results show that offspring of parents who mated in the presence of males with a high motor activity were significantly more active than offspring of parents that were paired in the presence of males with low activity. Anxiety like behavior and learning ability were not inherited in this way. It is possible that the phenomenon we discovered is important for maintaining a certain level of activity of specific populations of animals. It counteracts natural selection, which should lead to a constant increase in the activity of animals.

show abstract

“…In addition to natural selection, we can use artificial selection to create populations of animals with given individual characteristics. Thus, in experimental physiology and pharmacology, selective strains of mice and rats with distinctive behavioral features can be used, for example, that differ in the level of motor activity [2,3], anxiety [4–6], or learning ability [7,8].…”

Section: Introductionmentioning

confidence: 99%

Cross-Generational Impact of Epigenetic Male Influence on Physical Activity in Rat

Sudakov

Bogdanova

Nazarova

2022

Preprint

View full text Add to dashboard Cite

The aim of this work was to study whether epigenetic events at conception influence the formation of behavioral features found in adult rats. First generational inheritance of activity level, anxiety, and learning ability was studied. To separate genetic and non-genetic inheritance, mating of males and females with average motor activity was carried out in the presence males with high or low activity. Our results show that offspring of parents who mated in the presence of males with a high motor activity were significantly more active than offspring of parents that were paired in the presence of males with low activity. Anxiety level and learning ability were not inherited in this way. It is possible that the phenomenon we discovered is important for maintaining a certain level of activity of specific populations of animals. It counteracts natural selection, which should lead to a constant increase in the activity of animals.

show abstract

Hatano rats selectively bred for high- and low-avoidance learning: an overview

Cited by 9 publications

References 43 publications

Expression of Exploratory Activity of Rat Offspring Depends On the Expression of Exploratory Activity of Their Parents at the Moment of Mating

Expression of Exploratory Activity of Rat Offspring Depends On the Expression of Exploratory Activity of Their Parents at the Moment of Mating

Cross-Generational Impact of Epigenetic Male Influence on Physical Activity in Rat

Cross-Generational Impact of Epigenetic Male Influence on Physical Activity in Rat

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