Genetic Variation in Human Leukocyte Antigen and Susceptibility to Acute Myeloid Leukemia

Rizzo, Claudia; Accardi, Giulia; Caruso, Calogero

doi:10.1159/000365879

Cited by 5 publications

(8 citation statements)

References 7 publications

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“…HLA genes are highly polymorphic, i.e., they have many different alleles, involved in fine-tuning of the acquired immune responses. HLA classes have different functions [24,25,26]. (I) Class I (HLA-A, -B and -C) presents peptides from inside the cell to the surface of the cell, including viral fragments if the cell is infected by a virus.…”

Section: Hla and Hcmvmentioning

confidence: 99%

“…Different HLA alleles possess different peptide-binding repertoires and it is difficult for disease-related proteins to escape detection. Therefore, it is not surprising that several infectious and autoimmune diseases are associated with different HLA antigens, responsible for different humoral or cellular immune responses [24,25,26]. However, in the last few years, it is becoming clear that Class I antigens can play a role as ligand for KIR.…”

Section: Hla and Hcmvmentioning

confidence: 99%

“…However, in the last few years, it is becoming clear that Class I antigens can play a role as ligand for KIR. Therefore, several observed association of HLA class I antigen with infectious and autoimmune diseases can be explained by their role as ligands for KIR [26].…”

Section: Hla and Hcmvmentioning

confidence: 99%

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Role of Immunogenetics in the Outcome of HCMV Infection: Implications for Ageing

Aiello

Accardi

Candore

et al. 2019

IJMS

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The outcome of host-virus interactions is determined by a number of factors, some related to the virus, others to the host, such as environmental factors and genetic factors. Therefore, different individuals vary in their relative susceptibility to infections. Human cytomegalovirus (HCMV) is an important pathogen from a clinical point of view, as it causes significant morbidity and mortality in immunosuppressed or immunosenescent individuals, such as the transplanted patients and the elderly, respectively. It is, therefore, important to understand the mechanisms of virus infection control. In this review, we discuss recent advances in the immunobiology of HCMV-host interactions, with particular emphasis on the immunogenetic aspects (human leukocyte antigens, HLA; killer cell immunoglobulin-like receptors, KIRs; immunoglobulin genetic markers, GM allotypes) to elucidate the mechanisms underlying the complex host-virus interaction that determine various outcomes of HCMV infection. The results, which show the role of humoral and cellular immunity in the control of infection by HCMV, would be valuable in directing efforts to reduce HCMV spurred health complications in the transplanted patients and in the elderly, including immunosenescence. In addition, concerning GM allotypes, it is intriguing that, in a Southern Italian population, alleles associated with the risk of developing HCMV symptomatic infection are negatively associated with longevity.

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Section: Hla and Hcmvmentioning

confidence: 99%

Section: Hla and Hcmvmentioning

confidence: 99%

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Role of Immunogenetics in the Outcome of HCMV Infection: Implications for Ageing

Aiello

Accardi

Candore

et al. 2019

IJMS

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“…Concerning the meaning of the observed associations of HLA with COVID-19, it has to be pointed out that, in the last few years, it is becoming clear that Class I antigens can play a role as ligand for KIRs. Therefore, several observed associations of HLA class I antigen with COVID-19 might be explained by their role as ligands for KIR [61] (see above).…”

Section: Functional and Mechanistic Considerationsmentioning

confidence: 99%

The Role of Immunogenetics in COVID-19

Pojero

Candore

Caruso

et al. 2021

IJMS

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Coronavirus disease 2019 (COVID-19) is induced by SARS-CoV-2 and may arise as a variety of clinical manifestations, ranging from an asymptomatic condition to a life-threatening disease associated with cytokine storm, multiorgan and respiratory failure. The molecular mechanism behind such variability is still under investigation. Several pieces of experimental evidence suggest that genetic variants influencing the onset, maintenance and resolution of the immune response may be fundamental in predicting the evolution of the disease. The identification of genetic variants behind immune system reactivity and function in COVID-19 may help in the elaboration of personalized therapeutic strategies. In the frenetic look for universally shared treatment plans, those genetic variants that are common to other diseases/models may also help in addressing future research in terms of drug repurposing. In this paper, we discuss the most recent updates about the role of immunogenetics in determining the susceptibility to and the history of SARS-CoV-2 infection. We propose a narrative review of available data, speculating about lessons that we have learnt from other viral infections and immunosenescence, and discussing what kind of aspects of research should be deepened in order to improve our knowledge of how host genetic variability impacts the outcome for COVID-19 patients.

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“…Over the time, several studies have tried a possible association between ABO groups and diseases although with contrasting results [ 1 , 9 , 30 , 31 ]. Many of the performed studies present serious challenges because of a number of confounding factors [ 32 ]: i) the incorrect sample size leading to selection bias and false positive associations (i.e. the lack of statistical power); ii) different inclusion criteria, unsuitable mixing of data (cohort effects) referred to people of different age, incorrect control matching, i.e.…”

Section: Introductionmentioning

confidence: 99%

Possible role of ABO system in age-related diseases and longevity: a narrative review

2014

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ABO blood group antigens are expressed either on the surface of red blood cells either on a variety of other cells. Based on the available knowledge of the genes involved in their biosynthesis and their tissue distribution, their polymorphism has been suggested to provide intraspecies diversity allowing to cope with diverse and rapidly evolving pathogens. Accordingly, the different prevalence of ABO group genotypes among the populations has been demonstrated to be driven by malaria selection. In the similar manner, a particular ABO blood group may contribute to favour life-extension via biological mechanisms important for surviving or eluding serious disease. In this review, we will suggest the possible association of ABO group with age-related diseases and longevity taking into account the biological role of the ABO glycosyltransferases on some inflammatory mediators as adhesion molecules.

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Genetic Variation in Human Leukocyte Antigen and Susceptibility to Acute Myeloid Leukemia

Cited by 5 publications

References 7 publications

Role of Immunogenetics in the Outcome of HCMV Infection: Implications for Ageing

Role of Immunogenetics in the Outcome of HCMV Infection: Implications for Ageing

The Role of Immunogenetics in COVID-19

Possible role of ABO system in age-related diseases and longevity: a narrative review

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