1981
DOI: 10.1080/03014468100004871
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Genetic variation in Cumbrians

Abstract: Regional variation in the genetic constitution of the Cumbrian population is demonstrated in a survey of blood groups, red cell enzymes, and secretor status in a large sample of schoolchildren. In particular, the south and centre appear to be distinct from the remainder of Cumbria, but in different directions. The features of the central Lake District, tending towards gene frequencies observed in Norway, suggest that it may be a region in which the presence of a relict population is still detectable.

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Cited by 18 publications
(6 citation statements)
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“…Rh frequencies, which represent all haplotypes of d, were estimated on the assumption of HardyWeinberg equilibrium proportions. The gene frequency data were adapted to calculate genetic distances between the towns using a derivation by Roberts, Mitchell, Creen and Jorde (1981) of the R matrix method of Harpending and Jenkins (1973). The comparison between genetic and geographical distances was performed using the MATFIT program (Lalouel 1973), which rotates the two distance matrices to maximum congruence.…”
Section: Methodsmentioning
confidence: 99%
“…Rh frequencies, which represent all haplotypes of d, were estimated on the assumption of HardyWeinberg equilibrium proportions. The gene frequency data were adapted to calculate genetic distances between the towns using a derivation by Roberts, Mitchell, Creen and Jorde (1981) of the R matrix method of Harpending and Jenkins (1973). The comparison between genetic and geographical distances was performed using the MATFIT program (Lalouel 1973), which rotates the two distance matrices to maximum congruence.…”
Section: Methodsmentioning
confidence: 99%
“…Immunological and biochemical analysis of whole mixed saliva is useful in the diagnosis of various systemic diseases such as Gougerot-Sjogren syndrome (Pennec et al 1982), colon carcinoma (Northoff et al 1983), and fucosidosis (Den Tandt & Jaeken 1979), as well as in studies of human genetics (Teng & Tan 1979, Herron et al 1980, Roberts et al 1981. One important component in these anaiyses are salivary enzymes.…”
Section: Introductionmentioning
confidence: 99%
“…Consideration of present day migration and genetic drift having been taken into account, the way was clear for interpretation in terms of more ancient population settlement. The gene frequencies of this region are in fact more similar to present day Norwegian genes than to the neighbouring regions (Roberts et al, 1981b). The point I wish to make is this: we should not infer migration on the basis of gene frequency similarities without some independent documentation of the populations' relationship, and we should not exclude other microevolutionary processes from consideration without first assessing their applicability in the situation under review.…”
Section: Genetic Distributionsmentioning
confidence: 99%