Genetic variation in antibody response to diphtheria toxoid in Atlantic salmon and rainbow trout

Eide, Dag Markus; Linder, Ralph D.; Strømsheim, A.; Fjalestad, Kjersti Turid; Larsen, H. J.; Røed, Knut

doi:10.1016/0044-8486(94)90418-9

Cited by 12 publications

(4 citation statements)

References 27 publications

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“…The one exception was the r-p57 antigen of the salmonid pathogen R. salmoninarum, which elicited a strong antibody response in both fish species. Similar results have been described in Atlantic salmon which produced a strong antibody response to a bacterial pathogen of fish [19], but a weak response to diphtheria toxoid [20]. Etlinger et al [21] reported that adult rainbow trout also failed to respond to certain thymus-dependent antigens, including KLH, BSA, and human gamma globulin.…”

supporting

confidence: 69%

Antibody responses by chinook salmon (Oncorhynchus tshawytscha) and rainbow trout (Oncorhynchus mykiss) to various protein antigens

Alcorn

Pascho

2002

Fish & Shellfish Immunology

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supporting

confidence: 69%

Antibody responses by chinook salmon (Oncorhynchus tshawytscha) and rainbow trout (Oncorhynchus mykiss) to various protein antigens

Alcorn

Pascho

2002

Fish & Shellfish Immunology

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“…According to Chevassus and Dorson [26], studies on genetic resistance to disease in fish are in favour of genetic effects on the level of antibodies but do not yet allow relating them to the resistance to any disease. However, genetic variation on specific antibody production has been studied in relation to resistance [72, 73], and carp lines with a genetically determined high or low antibody production have been characterized [70, 74]. Chin et al.…”

Section: Discussionmentioning

confidence: 99%

Protective Acquired Immunity to Enteromyxum scophthalmi (Myxozoa) is Related to Specific Antibodies in Psetta maxima (L.) (Teleostei)

Sitjà‐Bobadilla

Palenzuela

Riaza³

et al. 2007

Scand J Immunol

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The acquired protection of three groups of turbot that had survived enteromyxosis outbreaks was tested by challenging with E. scophthalmi in three different experiments. The relation of such a response with the kinetics and duration of antibody production (determined by an ELISA) was studied. The progression of the infection was evaluated by PCR. In experiments 1 and 2, in which turbot had cohabited with highly infected fish during outbreaks, parasite prevalence and mortality were very low or null, and there was a progressive and statistically significant increase in the mean antibody production up to 350 and 152 days post‐exposure respectively. By contrast, in experiment 3, fish (coming from non‐infected tanks during the initial outbreak), both infection prevalence and cumulative mortality reached 92.8%, and specific antibodies were detected only in two fish. The observed differences in mortality after challenge appear to be related to the production of specific antibodies and it is probably accompanied by a repertoire of mechanisms of innate immunity. The exploitation of the immune system through breeding selection programmes as a possible strategy to control the disease is discussed.

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“…Fish innate immunity against some parasites has been studied (Forward, Ferguson & Woo 1995; Forward & Woo 1996), and differences among fish in the response to different antigens have been reported between, and within species because of genetic variation (Eide, Linder, Stromsheim, Fjalestad, Larsen & Roed 1994; Stromsheim, Eide, Fjalestad, Larsen & Roed 1994; Stromsheim, Eide, Hofgaard, Larsen, Refstie & Roed 1994; Hedrick, McDowell, Gay, Marty, Georgiadis & MacConnell 1999). The inability of L. salmonae to infect closely related fish may be an indication of host specificity in this parasite, which has been reported for other fish microsporidia (Pomport‐Castillon, Gasc & Romestand 1999).…”

Section: Discussionmentioning

confidence: 99%

Altered tissue distribution of Loma salmonae: effects of natural and acquired resistance

Sánchez

Markham

2001

Journal of Fish Diseases

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This study compared and contrasted the fate of the microsporidian Loma salmonae, a branchial pathogen of salmonids of the genus Oncorhynchus, upon exposure of (1) naive susceptible rainbow trout (RT) O. mykiss, (2) naive RT passively immunized with sera from RT previously exposed to L. salmonae, (3) previously exposed and resistant RT and (4) two species believed to be innately resistant to the parasite, Atlantic salmon (AS) Salmo salar and brook trout (BT) Salvelinus fontinalis. The fish were infected per os with viable L. salmonae spores. The infection was followed in the fish by detection of parasite DNA by polymerase chain reaction (PCR) at several times post‐infection. Spore germination and intestinal invasion by the parasite occurred in all groups of fish. In the susceptible RT, parasite DNA was detected in the heart by day 3 post‐exposure (PE), followed by the gill at 2 weeks PE, whereas visible xenoparasitic complexes (xenomas) were detected by week 4 PE. In the passively immunized RT, the parasite’s fate was similar to that of controls, however, its arrival in the heart was delayed by 1 week. A delay was also detected in RT which had been previously exposed to L. salmonae and then recovered from disease. In these resistant fish, the parasite was able to reach the heart by week 3 PE, however, it failed to reach the gill and form xenomas. In AS and BT, the parasite reached the heart and gills quickly, where it remained for 2 weeks before being cleared; xenomas never formed. We speculate that failure to complete the life cycle in AS, BT and resistant fish might be because of interference by the immune system in the development of the parasite, resulting in the absence of disease in these fish.

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Genetic variation in antibody response to diphtheria toxoid in Atlantic salmon and rainbow trout

Cited by 12 publications

References 27 publications

Antibody responses by chinook salmon (Oncorhynchus tshawytscha) and rainbow trout (Oncorhynchus mykiss) to various protein antigens

Antibody responses by chinook salmon (Oncorhynchus tshawytscha) and rainbow trout (Oncorhynchus mykiss) to various protein antigens

Protective Acquired Immunity to Enteromyxum scophthalmi (Myxozoa) is Related to Specific Antibodies in Psetta maxima (L.) (Teleostei)

Altered tissue distribution of Loma salmonae: effects of natural and acquired resistance

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